Considering the name of the comic and it's tendency to be extremely cynical, there are a number of truly touching comics throughout the archives.
For example, the end of the "Come Back" Arc had many tearing up big time.
Tangerine and Lil'E. Nuff said.
After learning that she put people in Hell, Nique tries multiple times to get some people out, but when it becomes clear she can't, she sends them cupcakes (which made them really happy). Then, she donated the money the Devil gave her to various charities, including some Slick had set up to help Squig with his gambling debts, allowing Slick to pay of the money Squig owed to Lil'E.
Especially touching as the story being told could very well be about Slick and Monique.
The entire Devil Girl subplot is shaping up nicely as a CMOH for Criminy and Fuschia (starting around here and coming up occasionally for several months). For example, observe this and this.◊ And it just got worse! Dammit, I need a tissue!
A number of the colour Sunday comics have their own special moments that you don't really find elsewhere in the strip, but thesetwo that bookend a week, when put together, really make you smile. The second one works on its own, but when you take into account the Sunday strip the week beforehand, it adds a little more to it.
You could perhaps call this one a Crowning Moment Of Heart-Rescuing; after 'Nique literally steals Slick's heart and is playing keep-away with it, it flies out of her hands and disappears into the hole to Hell. Slick loses consciousness, and so 'Nique climbs down the hole to retrieve his heart and fix it. Quite sweet. (Of course, then she gets a glimpse into it...)
Fuchsia had been previously warned by Baby Blue to delete her wiki before The Devil found out about it. But as she is about to delete the video files, she pauses, takes a look around, and uncovers all the paintings she's been hiding all this time. She proceeds to march out of the Devil's mansion, blowing up the security alarm as she goes. The image on her computer that prompted the decision, as seen in the final panel? Her and Criminey lying under the tree together.
In a way, the fact that Xanthe actually reads some of Slick's attempt at a sexy but still feminist-and-LBGT-friendly screenplay and gives him constructive criticism instead of just an insult, making him realize that his heart is still suffering from being locked away in the process.
When we see the day Blue and Fushia were hired by the Devil to work the mansion...it's not scary. Mr. D sees them having a rough time of things at the club (and maybe recognizes Blue from when they were teens) and picks them over the devil girls he's offered. Blue's reaction is what sells it. There's no dialogue, but you can just hear her telling Fyoosh "it's cool, I know this guy, it'll be okay now!"