These are what we call the 'YMMV items.' Things that some people find in this work. We call them 'your mileage might vary' because not everyone sees these things in the same way. This starts discussions in the trope lists, a thing we don't want. Please use the discussion page if you'd like to discuss any of these items.
Alternative Character Interpretation: Occurs in-universe and lampshaded/discussed in "The Nightman Cometh"; the rest of the gang notes multiple times that Charlie's play reads more like the account of a child being molested by an adult in his sleep than the romantic epic fantasy he envisioned. This also raises some distressing questions about Charlie and his relationship with his increasingly creepy uncle both in and out of universe.
Badass Decay: Inverted with Frank, who becomes more insane and Crazy Awesome with each episode. Subverted with Mac, who, despite his delusions, was never badass to begin with.
Big Lipped Alligator Moment: The giant sea turtle floating in outer space during the end credits of "Charlie Rules the World." However, it's a Brick Joke to one of Frank's line that is easy to forget. Still, it's just way too weird of an ending.
Broken Base: Some fans were upset by the fact that by season nine, Mac's basically canonically gay rather than just implied to be. Some people also think that it's an invention of the later seasons, despite the fact that there's an implication of his homosexuality right off the bat in the pilot episode. Other fans debate about whether Mac's homosexuality being made more obvious is less fun than when it was merely implied.
Despite only showing up a few times so far, the Lawyer has gained a following due to being one of the only outsiders who's gotten a handle on how to deal with the gang's outrageous behavior, trumping them consistently and effortlessly since the entire Gang is legally clueless.
Agent Jack Bauer, the indestructible junkyard cat.
Friendly Fandoms: With Pacific Rim, due to the presence of Charlie Day (and possibly the fact that Newt is basically a marginally-smarter version of Charlie...).
Growing the Beard: The show really came into its own during the second season, adding Danny DeVito as a contrast to the main four, turning Dee away from the Closer to Earth trope and generally going for more manic, darker, exaggerated tone.
Harsher in Hindsight: Any scene featuring the saintly Bruce Mathis is now very uncomfortable after Stephen Collins was revealed to have molested/exposed himself to at least three underage girls. Especially since a big part of Bruce's character is that he loves children and is great with them. And of course, there's this exchange:
Magnificent Bastard: The Lawyer. In one episode, the gang repeatedly pesters him for different legal reasons, like for patents and a job contract, their tactics involve assaulting his secretary, stalking him, hiring him a hooker, threatening to rape his wife (as an act of good faith), up until he gives in, resolves all their troubles legally, and gets the inventions to patent. Then at the end, he reveals that the contracts everyone signed gave him the profits from any and all sales of the inventions, as well as a restraining order from them (and back-up copies, because the first was eaten in an attempt to stop him).
Memetic Badass: Agent Jack Bauer. Not surprising given that the cat is canonically indestructible.
Memetic Molester: Dennis, which was kind of inevitable, given his screwed up ideas of consent.
Nearly every aspect of Charlie and Frank's living habits. Charlie has such bad oral hygiene that he can effortlessly pull out his teeth without feeling anything, and he presumably doesn't change or wash his underwear as it started to fall apart after a failed attempt at a wedgie. Frank poops wherever he feels like it because it's funny to him, and he clips his toenails with a steak knife which he also uses peel fruit.
Rewatch Bonus: A lot. If you're not paying attention you'll miss a bunch of character important lines, hints at future events, and small, easy-to-miss jokes. For example, "Who Got Dee Pregnant?" is even funnier upon rewatch because you know that Dee's lying about one of the gang being the father of her child.
In "Who Got Dee Pregnant?" the episode begins with the guys discussing a plan to spend the night at the city museum, dodging security and generally enjoying themselves. Though the episode was also funny, it's a shame this never came to pass.
Charlie and Dee working at a high school, which lasted for all of two episodes.
Too Cool to Live: Country Mac. But it's less an example of him being killed off because he will make the gang look bad in comparison and more because it's unspoken rule that no one cool can be a part of the Gang.
Charlie the Butt Monkey is often so pathetic that the viewer is intended to feel sorry for him and the Gang is even moved to pity him on a few occasions. In contrast, Dee is another Butt Monkey, but she's so shrill and spiteful that she never gets any woobie moments.
Rickety Cricket, who is introduced this way and grows steadily worse with each appearance.