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- Played with in a The Smurfs comic: one of the Smurfs dreams of travelling to outer space in a spaceship he builds. Not wanting to disappoint him, Papa Smurf concocts a convoluted plan to drug him and make him thinks he's travelled to another planet populated by Smurflike humanoids called Swoofs. So convoluted, in fact, that after Astrosmurf "returns" (after drinking a similarly drugged beverage given to him by the Swoofs), another Smurf contemplates on doing the same thing, only to be overridden by the rest of the village, who practically yell the trope name at him. They do go through it again, though, in the Animated Adaptation episode "Dreamy's Pen Pals".
- At the end of the fanfic Fanfic Is Crapsack, the "trollfic," a diabolical entity embodying horrible fan fiction, tries to make a comeback as a minuscule, slowly-growing glob hiding in the cracks in the floorboards of the Ponyville Library. Twilight Sparkle drives it out of the floor by pouring boiling coffee on it, then destroys it by smacking it with a copy of Diana Hackney's Rules for Writers. It pops like a cyst, leaving behind a little spot of soot.
- Not actually at the end, but in Dragon Ball Z Abridged, Dende cites this trope when he decides to nix immortality from the resurrected Shenron, not wanting another Freeza dropping in and causing trouble.
- At the end of Kingdom of Heaven, Richard the Lionheart rides to greet Balian and tries to recruit him for another crusade. Balian simply responds: "I am the blacksmith".
- Never Say Never Again Bond quits the service at the end of the film, though he does wink at the camera when he says it.
- Tremors 2: Aftershocks had Earl act this way at the beginning. It didn't take.
- In Freaky Friday (2003), the titular "Freaky Friday" Flip is caused when an older Chinese woman (the mother of the owner of a Chinese restaurant) gives the characters magic fortune cookies. At the end, the same Chinese restaurant is catering the big wedding, and the restaurant owner tackles her mother to prevent her from giving the magic fortune cookies to the grandpa and little brother.
- At the end of the Boris and Natasha movie, Boris blows up a crate of time travelling MacGuffins that individually reverse time for ten seconds when damaged. This causes time to reset to the beginning of the movie. Then they decide that they don't want to go through all the grief they went through over the course of the film a second time, so instead of delivering a priceless treasure to Fearless Leader and starting the plot, they sell the treasure and retire to Tahiti.
- At the end of Strangers on a Train, the main character finds himself in a train carriage with a stranger who recognises him and tries to strike up a conversation. Having just gone through a hell of an ordeal resulting from someone else on a train recognising him and striking up a conversation, the main character gets up and goes to another compartment without saying a word.
- Carry On Henry. Cardinal Wolsey and Cromwell call for the executioner to go ahead and chop their heads off rather than help King Henry VIII arrange yet another royal divorce.
- At the end of Bored of the Rings, Frito, having returned to his digs, is visited by a mysterious stranger who thinks he's the kind of person that takes quests. He slams the door, locks it and swallows the key.
- In the final Harry Potter book, Harry gets the Elder Wand and has the opportunity to keep it (leading to a possible Here We Go Again ending), but decides to put it back in Dumbledore's grave to end the cycle of violence after using it to repair his old wand. Ron asks if he's sure and Harry tells him "That wand's more trouble than it's worth. And quite frankly, I've had enough trouble for a lifetime."
- In the film he goes further; he snaps the wand in two and throws it into an abyss.
- In the short story "Chivalry" by Neil Gaiman, a little old lady finds the Holy Grail going cheap in a second-hand shop, and buys it because she thinks it'll look nice on her mantelpiece. Much excitement ensues. At the end of the story, she's back in the same shop, and finds an exotic oil lamp but decides, on reflection, to leave it where it is.
- During Galaxy of Fear, DV-9 goes on several adventures but ultimately puts himself on a bus, tired of the constant danger and excitement. He reappears in the last book and helps the others, for a moment, but declines to leave with them for this reason.
- In the epilogue of John Dies at the End, John and Dave are trying to have a game of basketball when they are drawn into another parallel Earth and asked to save it from a monster invasion. They find an excuse to leave, and let some teenagers with attitude handle it instead.
- In an episode of A.N.T. Farm, the A.N.T.s plan a heist to steal a painting that Fletcher made and some guy is claiming credit for. The heist is a success; however, Fletcher puts an exact replica of the painting in its place rendering the whole thing pointless. When he tries to reform the group and give a rundown of their roles again, Chyna stops him.
- Done repeatedly in a single episode of The Cosby Show. It's Thanksgiving and there's a huge storm raging outside. Despite that, Clair keeps sending Cliff to get stuff that she'd forgotten to get ahead of time. Each time he returns from the store, the first thing he says is "I'm not going back out there". He keeps going back out there.
- In one episode of Drake & Josh, after taking the fall for helping Megan hide a goat from their parents, the boys decide against doing the same when she brings home a zebra.
- The Flash (2014): At the start of season 3, Barry messes up the timeline by going back in time. He goes back in time again to fix what he did. This results in a timeline that is mostly fixed, but not quite the same as his original. He goes back in time to fix it as well... only for Jay Garrick to smack him out of the Speed Force and give him a stern talking-to on the consequences of repeated time travel.
- In The Monkees episode "Don't Look a Gift Horse in the Mouth", the band, having just finished ensuring that a horse that they were stuck with by a kid got a good home, are approached on the beach by another kid who just happened to be looking to get rid of a camel. The instant they see this, the Monkees run away as fast as they can before the kid can say anything and given that the show cuts to a music sequence with them on a dune buggy and motorcycles, they are apparently really serious about avoiding getting stuck with another beast of burden.
- In Season 4 of Person of Interest, Harold Finch tries to invoke this on the rest of Team Machine, but they all slowly work on him to bring him around.
- By the end of the sixth episode of A Series of Unfortunate Events (2017), the Baudelaires have realized that Mr. Poe is and always shall be completely and utterly useless, so rather than go with him and be dumped God-knows-where and go through the same bullshit once more, they choose to take control of their fate and stow away in a truck to the Lucky Smells lumber mill.
- The Suite Life on Deck episode "Maddie On Deck" is about Maddie catching the attention of a prince, who turns out to be an eight-year-old boy. The prince proceeds to attempt to force her into marriage. In the end, she has caught the attentions of the prince's brother, Timmy, and has a We Are Not Going Through That Again moment. As it turns out, Timmy was actually a hot guy around the same age as her.
- In Peanuts, Charlie Brown is returning home from the best summer camp visit of his life helping and gaining a new friend. As his bus pulls out, he sees a new crop of kids who could use some help, but he sits back with a satisfied smile and says "Let them go, I've done my hitch."
- The ending of Telltale Games' Back to the Future game series. Upon finally arriving home, Doc and Marty are visited by Marty's future self in an inverted homage to the first movie's Sequel Hook. Then two more future Martys show up. They all insist they come back with them into the future to fix the timeline. Doc and Marty simply get back into their own DeLorean and drive away, leaving the three alternates to fight amongst themselves.
- In an episode of Dave the Barbarian, the gang are visited by Lula's sister Molly, who is actually Thor's hammer Mjolnir. After they get them back together, they're visited by Neptune's trident and immediately shut the door.
- The Earthworm Jim episode "Hyper Psy-Crow" almost has a Here We Go Again ending, but when Jim comes in and complains about it (even using this exact term), they decide to Drop the Cow instead. The dialog:
Psy-crow: Oh well. Here we go again!
EJ: Hold it! We are not going to do a "Here we go again" ending on my show!
(after Psy-crow asks what they'll do instead)
EJ: Take a guess.
Psy-crow: Uh... The cow thing?
(a cow falls on Psy-crow)
- In an episode of Family Guy, Stewie and Brian have lied to Loretta, saying that Cleveland wants to get back together with her, in order to allow Brian a chance with his ex (Cleveland's then-current girlfriend.) Loretta comes to Cleveland, saying that she's sorry she cheated on him and does want them to be a family again...and he considers it, though he doesn't want to give up Carolyn. When he finally does talk to Loretta, he tells her that the time they shared was special and he does care about her, but also that he's moved onto a new chapter of his life and that she should do so too.
- In a later episode when Joe's son Kevin comes to Thanksgiving after faking his death in Iraq, the episode ends with another Kevin saying the first one is an impostor. Peter lampshades this saying that there's no more time left in the episode.
- The Flintstones episode "Dr. Sinister" where Fred and Barney just come back after being shanghaied into a terrifying James Bond-like adventure with Madame Yes. When Yes appears on their front door at the end, they slam the door and begin boarding it up in fright.
- The Penguins of Madagascar, "Treasure of the Golden Squirrel". After the penguins had been involved in an exciting treasure hunt involving a cursed artifact, a pigeon gives them a silver feather and instruct them to guard it with their lives. Skipper is excited at the prospect of a second adventure, but when he turns around he finds that the others have left, wanting no part in it.
- Popeye: At the end of one episode of the treasure seekers segment, a descendant of Joan D'Arc wants to hire Popeye and Olive to seek one of her artifacts. They refuse.
- Regular Show:
- In "Eggscellent", Rigby is put in a coma trying to eat a giant omelette, which triggered his egg allergy, and the only thing that can wake him up is winning the net hat given as a prize to anyone who can successfully eat the whole thing. After Mordecai eats the omelette and gets the hat, they see an advertisement for a restaurant that will give free T-shirts to anyone that can eat a giant steak. Rigby suggests they attempt that challenge as well, and in response the rest of the staff try to remove his hat to put him back in his coma.
- In "Sleep Cycle", Mordecai and Rigby get no sleep after watching a marathon that ran for an entire weekend and have to fix their sleep cycles by going through a magical life-or-death challenge (again). When they see a commercial for another marathon and are prepared to do it again, Skips punches out the TV.
- The Secret Saturdays: Happens at the end of "Once More the Nightmare Factory" after the team has escaped from Argost's cryptid-infested mansion:
Doc: It's over. We won.[Drew, Doyle and Zak motion to warn Doc of the large seagoing cryptid behind him]Doc: No. We won. I'm not turning around and looking at it. We won.
- Sonic Boom:
- In "Can an Evil Genius Crash on Your Couch for a Few Days?" Sonic lets Dr. Eggman stay at his house for a few days while the latter's base is under renovation. It later turns out this was a ruse so Eggman could exhaust Sonic and his friends so they'd be too tired to stop his Obliteratorbot. The Obliteratorbot malfunctons and attacks Eggman's base, forcing Eggman to team up with Sonic and his friends to stop it. At the end of the episode, when Eggman's base is destroyed for real, Sonic just decides to drop Eggman off at his destroyed base.
- In "The Curse of the Cross-eyed Moose", Sticks sends her and her friends on a perilous journey to find a marmoset monkey when she believes they are cursed following her encounter with a cross-eyed moose. At the end of the episode, after Sticks believes the curse is removed, she comes across a moss-covered, seven-legged spider, believing she and her friends are cursed again. Before she can send them on another perilous journey, Knuckles flicks the spider away and says, "Curse broken!"
- Star Wars Rebels: In "Visions and Voices", after getting possessed by a Nightsister ghost as a result of going along with Maul's demands by letting Ezra go to Dathomir with him, as this is only the latest in a string of bad things to happen to him when they've worked with Maul before, Kanan declares that he doesn't care what Maul is holding over their heads next time, they are not working with him again.
- In the World's Greatest Super Friends episode "Lord of Middle Earth", Gleek realizes his fantastic adventure was just a dream. But just as he relaxes, he sees a shadowy figure that looks like the same kind of Troll that was in his dream adventure. Rather than investigate, Gleek simply shrugs and goes back to sleep.
- In the last episode of The Super Hero Squad Show, when the Infinity Sword is broken into fractals again, Falcon states that he's not hunting them all down again.
- An episode of TaleSpin begins as Baloo and Louie were being chased by a giant walrus after being talked into a treasure hunt by a girl. After escaping, they vowed not to get involved with an adventurous woman again, only to spend the episode helping a female archaeologist look for treasure. Once that's over, a woman on the streets shows them a map and asks if they're interested in looking for some treasure. The two exchange glances and then promptly rip the map over her head, and leave.