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- Kumacy, Perona's personal zombie teddy bear from One Piece.
- Averted with Kon. He may seems creepy at first, but poor guy is totally harmless.
- This is played with during the Fullbring training of Ichigo: Riruka shuts him in her doll house and his "opponent" is a Yakuza boss trapped in a stuffed pig.
- There's a scene in Tenchi Muyo 2: The Daughter of Darkness where Tenchi and Ryoko are pulled into Yuzuha's realm and dumped into a toy room. There, they're greeted by a killer cadre of, you guessed it, toys: including a psychotic teddy bear! They soon dispense with the pleasantries, and unleash a rapid fire barrage of knives!
- Dirty Pair Flash: Murderous Monica, aka "The Pink Sniper", is a teen assassin with a stuffed teddy bear named Mr. Mackie. She uses it as a portable weapons cache, which includes everything from her hair dryer to a laser gun, hand grenades, and an acidic bubble blower among other things. When enraged, she can even transform it into a Humongous Mecha, complete with Gatling guns and missile launcher, and pilot it!!
- The psychic children in AKIRA first attack Tetsuo after forming a giant teddy bear and other toys out of debris. It's a lot creepier than it sounds.
- The Ankle Biters from Medabots use a teddy Medabot appropriately called Churlybear. Churlybear looks harmless enough until its owners are provoked into Robattle, at which point its eyes light up with sinister red... and much asskicking ensues. The Medabot can use several extremely powerful explosive blasts, but its signature move is a gravity beam that can completely negate an opponent's speed and agility while throwing it around like a helpless doll - if this attack hits, the battle is pretty much over (Unless, like Spyke, you get extremely lucky...)
- Pictured above: WaruMonzaemon (and regular Monzaemon, when he's somehow turned evil) in the Digimon franchise.
- There's a Buffy the Vampire Slayer comic with some kind of possessed stuffed bear that was used in an attempt to get at Dawn.
- After his first defeat, Ashley Guthrie from Hack/Slash became trapped in his old teddy bear. He didn't enjoy it◊.
- Judge Dredd: One short strip featured Dredd fighting a mutant who looked like a plush teddy bear and went on a murder spree.
- Lotso from Toy Story 3.
"Where's your kid now, Sheriff?!"
- Screamers. Killer robots looking like little boys, carrying killer robot teddy bears.
- In Dolls, after Rosemary throws Judy's teddy bear in the bushes, the bear comes out of the bushes life-size and rips through the teddy bear look to reveal a real bear that attacks and kills her parents. However, it's just Judy's imagination so, it's subverted.
- The Free Kingdomers in the Alcatraz Series disguise their grenades as teddy bears, the logic being that the enemy shouldn't know to run away from their weapons. Plus, it means that children will be more willing to play with them, which means they'll have a defense handy.
- In Mercedes Lackey's short story The Last Of The Season, a little girl's teddy bear comes to life to protect her from a serial rapist/murderer, which it does with extreme prejudice.
- The episode "Ursa Minor" from Tales from the Darkside.
- Inversion: In an episode of Supernatural with a wishing well, a little girl wishes her teddy bear to life; it becomes suicidal. It eats its gun, but it doesn't work.
- Saturday Night Live - on the "Consumer Probe" talk show, sleazy toy manufacturer Irwin Mainway doesn't see the harm in his "Teddy Chainsaw Bear".
- Radiohead's Modified Bear logo, which is meant to be a genetically modified teddy bear.
- Dice Funk: Anne uses a teddy bear as her holy symbol, which means that she uses it to channel certain attacks, including one that incinerated an undead monster.
- Naughty Bear: The whole game is based around a bullied teddy bear in a city full of other teddy bears. And he decided to make them pay. Hard.
- League of Legends: Annie's teddy bear Tibbers. He's a "shadow bear", that is to say a gigantic burning ursine abomination, spellbound to Annie. She carries him around inside a teddy bear toy.
- Silent Hill. Some of the enemies you encounter in the altered world are Furry Bunnies. OHGODWHY.
- In the Hunter: The Reckoning video game, Kaylie's teddy bear becomes possessed by evil spirits and grows to gigantic size before killing her parents, leading to a boss fight.
- MapleStory Ludibrium is full of these.
- In Final Fantasy X, Lulu uses her dolls as a focus for her magic, or to act on its own and attack. No one knows how she does this.
- Guilty Gear: Bridget has several attacks which involve the use of his teddy bear, as well as his yo-yo. One attack has it drift toward the opponent with spinning blades, and another has it grow to gargantuan size and run the opponent over on a flaming tricycle.
- Typically in CarnEvil, the boss of the Freak Show is a giant baby named Junior. If the arcade owner wishes, they can switch Junior out for a giant teddy bear named Deaddy.
- In Persona4 Teddy looks like a teddy bear, but is a deadly fighter with his claws. It's a good thing he's on your side! His Shadow, on the other hand...
- In The Sims 3, that's probably Dexter The Bear, a stuffed Bear that gives you the ability to kill other Sims with either a knife, a poker, or a hammer. The hammer lets you kill toddlers too, which gives way to the creepy toddler behaviors. That is, when Dexter worked properly and didn't crash the game.
- The Tediz in Conker's Bad Fur Day are an army of these, built by Professor Von Kripplespac with an intention to Take Over the World.
- Shiki Misake of The World Ends with You once hand-sewed a stuffed cat and named it Mr. Mew. It serves as her sole means of attack in the Reapers' Game.
- Monokuma in Danganronpa. He won't kill you himself (except for when he executes people), but if the two of you are in the same room (or same building, or on the same landmass), he's probably trying to convince people to murder you.
- In Danganronpa Another Episode: Absolute Despair Girls, the protagonist must fight for their lives against a legion of weaponized Monokumas.
- The third installment of Splatterhouse has the possessed teddy bear of your kidnapped son act as one of the bosses. It actually looks really soft and cute... until the top of it explodes off, revealing a horrid, visceral monstrosity with long, clawed arms. When it's beaten the entire thing swells and blows up in a green, gory mess...
- Putty has teddy bears that charge at you and explode.
- Pamela Ibis' main form of offense in Mana Khemia: Alchemists of Al-Revis is a pink teddy bear equipped with craftable Wolverine Claws and possessed by the Mana of Life. Among other things, it can grow tremendously and suck the life out of her opponents.
- Plenty of cute-looking toylike Pokémon can still viciously attack you. Snorlax looks like a big fat sleepy teddy bear, but that won't stop it from mauling opponents' faces off. Teddiursa looks even more like a teddy bear, and while it's not very strong it does evolve into the significantly less huggable Ursaring. In Gen 6, there's Pancham, a little panda bear cub, who grows up into the vicious yet honorable Pangoro, which stands a full head taller than an Ursaring.
- In Paranormal Syndrome, the first paranormal encounter that chases and tries to kill Mikoto is a cursed, knife wielding teddy bear that was animated during Hitori Kakurenbo (One Man Hide-and-Seek). Only shortly before the events of Chapter 1, the teddy bear had also killed most of the family members of Mikoto's friend.
- Phantasy Star Online 2 has the Bonta Bearadda, a Darker in the form of a cutesy, pastel-colored teddy bear that's notable for being completely passive initially, simply standing still and constantly turning to face you as you move about. The moment it takes damage, however, it'll turn around and reveal its ugly side that's possessed of a nightmarish chest mouth and some mean claws before taking chase at a speed that's either sluggish or alarmingly fast depending on the difficulty.
- A teddy bear is one of the items that can be possessed in Haunt The House. It stretches itself so hard that it nearly rips itself in half, showing its seams.
- Reynardine of Gunnerkrigg Court is trapped in a stuffed wolf, and under Antimony's control, but can transform into a life-sized and quite menacing wolf when he feels the need. And he's stuffed full of lockpicks he likes to use like sharp implements.
- In Sparkling Generation Valkyrie Yuuki, Loki is able to possess a particular stuffed doll, which limits his powers to some extent. But he's almost never seen without a knife.
- Liv Tyler, aka the Uber Bunny, from Homestuck was once an adorable stuffed rabbit. Over many regiftings and falls from a meteor has been transformed into a patchwork cyborg rabbit (complete with mismatched glowing red/green eyes). It was also equipped with miniature versions of the strongest weapons available for each of the four players' weapon types. However, it was intended to help the protagonists and was quite loyal to that end.
- Bertram from "The Littlest Atheist" has a killer teddy left to him by his father as a bodyguard.
- Nuggles from I Want A Drink is at least 7 feet tall with huge talons and ripped fur revealing his organs and skull. He plays The Dragon to the Big Bad Squirt.
- He didn't kill anybody as far as we know, but Pedobear probably raped your childhood even more than all the other examples.
- The Nostalgia Critic once had to deal with a psychopathic Teddy Ruxpin doll that wasn't very happy about being criticised.
- Yu-Gi-Oh! The Abridged Series turns Rebecca Hawkins' teddy bear into one of these, though so far all it's done is make threats.
- The Mortasheen universe has a whole line of "Doll" bioconstructs with varying levels of evil. Despire, for instance, is a very creepy living teddy bear, who works both as a toy and a killing machine, and can psychically switch others' positive emotions to negative and vice-versa, an ability which is intended to calm unruly children but works great for combat as well:
Attackers may find themselves only giggling as the monster slices into them with its retractable bone-blades, usually aiming for the belly or groin.
- Flippy from Happy Tree Friends is not a stuffed animal, but because of the deceptively cutesy style of the cartoon, has the proportions and general look of a teddy bear.
- Because the creator of Vaguely Recalling JoJo can't recall what Empress and Ebony Devil look like in JoJo's Bizarre Adventure, they look like this.
- 5 Second Films: In "Secret Admirer", Kelsey finds out that she has a secret admirer who sends her a stuffed teddy bear to sleep with... but it turns out that the bear is in fact the admirer.
- Huggles T. Bear in Zoofights is what happens when unscrupulous scientists take a grizzly bear, equip it with Wolverine Claws and a chest laser (obviously as a parody of the Care Bear Stare), and send the poor thing to fight other abominations to promote a toy company. It's that kind of series.
- An evil teddy beats causes a dreamer to shift between worlds in a nightmare titled "Trapped in the Other World" on the Nightmare Project.