When Dan performs the final Coup de Grace (x2) on the Metal Gear RAY when playing Metal Gear Rising: Revengeance, the sheer spectacle of it leaves him speechless the first time. The second time just causes him to question whether it's a Metal Gear game through his laughter.
"This is about as Metal Gear as a game is fucking Fifty Shades of Grey! I don't even understand what's going on!"
Dan making Kennith Kennithson a "pwetty pwincess" in his The Sims 3 video.
Noticing an odd shaped shadow appear on the beach as he comes ashore, only to turn around and see his own ship falling out of the sky into the ocean apropos of nothing. Dan is understandably confused.
Dan comes board his now beached ship: I'll be honest lads, you kind of fucked the boat.
Encountering a jaguar with some odd pathing issues.
Dan doing a wildlife documentary: And here we see the wild jaguar confused *breaks out in laughter as the jaguar falls off a platform* and falling off of a platform. *jumpcut* Ah, and after a little while we see the jaguar has to its home plinth. Oh its seen me, oh and its confused, oh and its confused, and its dropped off again. The jaguar, natures really stupid fucking creature.
In his Spider-Man 2 playthrough, after throwing a bunch of enemies off a roof he says this gem:
Dan: Spider-Man, hero of many, murderer of some.
In the same video, right at the beginning:
Dan: I'm Spiderma— shit, I left the web fluid at home. *SMAAAAAAAAASSHHHH*
In the Worms Crazy Golf video, Dan decides to kill a sheepwho ate his ball by whacking golf balls at it. His first golf ball flies right over the sheep and nails a groundskeeper, prompting him to commit suicide.
At around 15:32 in his video on Cook, Serve, Delicious!, he is casually flipping through the list of upgrades, but then glances at the entry for "Enhance Security", which uses an image of a handgun. This prompts a hilarious, "What the fuck?!"
Doc Mitchell from Fallout: New Vegas tells Dan that when he says a word to say the first word that comes to mind. Dan answers every one with "Penis" and almost says that when Doc Mitchell asks "Mother", but corrects himself before he can finish saying the word.
During the first The Sims 3 video, Kennith nearly falls into the toilet from having the Clumsy trait.
Dan: I'm so glad I bought that life preserver!
"The opposite of a LEGO Minifigure of the Queen...is Spiderman.