Voiced by Rob StefaniukAn overly-optimistic mutant who has no actual knowledge of his purpose in life or what he's spliced from, yet yearns to find out.
Voiced by Joe PinguePeri's best friend; a combination of a chicken, cow, shrimp, and a pig who was designed to be the ultimate eating animal, who's basically a bottomless pit with an attitude problem.
Two-Legs Joe and Lord Wingus Eternum
Voiced by Patrick McKenna and Tom McCamus, respectivelyA short-tempered two-legged rhinoceros with a small bird attached to his rear end. (Until it was revealed that the bird's name (well, his nickname that is) was Lord Wingus Eternum; a Zen master who was once banished by his peers for never removing the growth on his foot that has always interrupted his studies, which grew into Joe).
Voiced by Katie CrownAn intelligent non-mutated platypus who usually feels out of place from all the other inhabitants due to her being the only non-mutant character on the island. Could be quite violent when provoked.
Princess Pony ApehandsVoiced by Kedar BrownA gorilla-pony with the uncanny personality of a six-year-old girl. She does demostrate her ungodly size and incomprehensible strength quite well,like walking through solid structures like it was made out of toilet paper.
CompuhorseVoiced by Patrick McKennaA horse cyborg who, once a normal horse, was involuntarily merged with computer parts from a freak hardware factory explosion. Thanks to his new-found intelligence and ability to speak via voice programming, he can explain the wild phenomena the other characters somehow crossed paths with.
Fuzzy SnuggumsVoiced by Julie LemieuxA cute and lovable critter who lives and breathes the urge to explore the island and the outside world, but could never do it right due to Karma having him blacklisted on Facebook.
Mister Smarty SmartsVoiced by Mike KissAn antagonistic, somewhat "knowledgeable", larger-than-life dolphin-chimpanzee who constantly attempts to subdue the townsfolk into doing his bidding and changing the island into an imperialistic "him-topia". Too bad his plans always backfire from either being thwarted by the protagonists, or that it's anything except being fool-proof.
OctocatVoiced by Katie CrownA (you guessed it) cat-octopus who accompanies Mister Smarty Smarts with his plans to dominate and take over the island. Always speaks in meows.