- Acceptable Targets: After Max's air-conditioning unit falls out of his apartment and crushes a mime artist.Narrator: "Luckily, [Max's] manslaughter charges were dismissed, because he was labeled mentally deficient, and unlikely to have a motive for killing a mime artist. Unlike most people."
- Alternative Character Interpretation: A minor one about what Max was more upset about: Mary trying to cure his Asperger's syndrome or just the fact that she used him as a guinea pig without asking.
- Award Snub: This movie received no nominations at the 82nd Academy Awards (see Screwed by the Network). It has however won the Cristal du long metrage at the Annecy Film Festival, along side Coraline in 2009
- Awesome Music: The excellent use of "Perpetuum Mobile," by the Penguin Cafe Orchestra, as the film's leitmotif.
- Heartwarming Moments: Several. Especially the ending where Mary looks up and sees all the letters she ever sent to Max all over the ceiling.
- Moment of Awesome: Max gives Mary a rather silly bit of advice on how to stop another kid from bullying her. It works.
- Nightmare Fuel: The "Que Sera Sera" sequence, especially when it is revealed in the midst of it that Mary is pregnant.
- Tear Jerker: Again, the "Que Sera Sera" sequence, and all that built up to it. Mary's sheer misery and self-loathing is utterly tragic.
Max: You are my best friend. You are my only friend.
- Mary's second letter to Max as a child, in which she details a bully grabbing her sandwich and pissing on it, then making fun of her birthmark. This culminates in her crying as she writes the letter, even telling Max her tears are smudging the paper, then asking him as her voice is breaking if he's ever been bullied.
- The fact that Max probably would have lived long enough to see Mary if he hadn't had such an abysmal diet (bread and chocolate bars) for years to the point of morbid obesity.
- And Max's letter, especially the Meaningful Echo at the end.
- Ugly Cute: Mary. Well, maybe not ugly but given the style of animation, as well as her whole character, it sort of fits.
- Mary's baby.
- Vindicated by Cable: While still underrated, it has enough of a following where it's on the IMDb Top 250 highest rated movies of all time.
- What an Idiot!: When Max writes to Mary and tells her of his AS diagnosis, he makes it clear that he doesn't like the idea of being cured, as he does not see anything wrong with having AS (a sentiment held by many real life people with AS). Yet, when she writes him after graduating college, she apparently expects that he will be pleased by the news that she is researching a cure and hopes to celebrate this fact with him. However, given the Time Skip between these two events, this becomes a bit more understandable.
- The Woobie:
- Mary. She is bullied as a kid, her husband leaves her, she unintentionally angers Max with her book about Aspergers Syndrome and is nearly Driven to Suicide because of it.
- Max. He has Aspergers Syndrome, is put in a institution and has no friends.
YMMV / Mary and Max