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As a WMG subpage, all spoilers are unmarked as per policy. You Have Been Warned.

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    Pre-Season 1 guesses 
The New California Republic has collapsed, or been severely damaged, in the years since the Second Battle of Hoover Dam.
So far, none of the promotional materials released for the series have made reference to the NCR, which is very strange considering A) the contrasting prominence of the Brotherhood of Steel (who weren't all that welcome in the NCR the last time we saw) and B) the series being centered near the Los Angeles ruins (AKA Angel's Boneyard), which is almost at the center of the Republic. Either the NCR lost and was driven out, or their victory was a hollow one and they couldn't hold together. Perhaps they are still around, they've just had to pull away from Angel's Boneyard.
  • It's worth remembering that the urban sprawl containing Los Angeles is just under half the size of the state of Connecticut, and even larger than it if one counts outlying areas grouped into the "Greater Los Angeles Area" as defined by California's state government. The NCR's population and prosperity are higher than the rest of the wasteland, but both are still at a miniscule fraction of pre-apocalypse society. It's equally possible that the NCR simply doesn't have firm control of the entire Boneyard, and/or that the Brotherhood forces seen in the trailer have arrived suddenly and unexpectedly.
  • Partially Jossed by the full trailer. The NCR has a notable presence at Griffith Observatory and is shown fighting against a Brotherhood incursion there. How strong they are is still up in the air.
  • However, the finale reveals that Vault-Tech deliberately sabotaged the NCR in the interim between New Vegas and this show, as they have been the Greater-Scope Villain of the entire series and most likely didn't want competition in their plots to Take Over the World.
  • Confirmed. By the end of the first season, the last bastion of remnants is killed by the Brother of Steel. Even before the series start the city of Shady Sands was nuked and New Vegas was abandoned collapsing the nation. The only remains left are a handful of soldiers and some Anti Air at the Griffith observatory.

The Brotherhood of Steel forces we see are returning to California due to a Treaty signed with the NCR.
One of the possible endings of New Vegas sees the NCR and Brotherhood sign a peace treaty with the Brotherhood agreeing to protect Mojave Wasteland roads in exchange for NCR returning their stolen power armor. Perhaps this shows the treaty has been expanded, and now the Brotherhood are coming to protect California roads. Or the Brotherhood is now at peace with the NCR and trying to help their allies.
  • Jossed. The official trailer shows the Brotherhood actively fighting NCR forces as Griffith Observatory.

This series will be an Alternate Continuity of the main game series.
The wasteland seems far more lawless and dangerous than it should be by this time, The Brotherhood is still in prominence in California and the NCR isn't mentioned, Vault 33 still hasn't opened...perhaps the series is a Broad Strokes adaptation on established Fallout history, in the same way the old Fallout movie script was.
  • Jossed by Todd Howard himself in interviews; the show is set in the same continuity as the games and is considered canon to them, taking place 15 years after New Vegas.

Ron Perlman will have a cameo in some sort.
He could most likely be a narrator for the first and last episodes, with the last episode having him deliver the "war never changes" line
  • Jossed, although the line is said by another character.

The Brotherhood forces in the trailer are an expedition/reinforcements sent by Arthur Maxson
The construction of the Prydwen took around 4-5 years according to Fallout 4, more than enough for Maxson's East Coast branch of the Brotherhood to produce another and send it west between that game and this show. The scenes in the trailer showing them in a pitched battle are likely them joining the fight against the NCR.

The "powerful artifact" mentioned in Vanity Fair's preview article is a Weather-Control Machine
Vanity Fair's preview mentions that much of the series' conflict is driven by a search for a "powerful artifact" that could change the balance of power in southern California. The countdown livestream for the trailer mentioned inexplicable snowfall in Los Angeles in the leadup to the bombs, and snow can be seen in the trailer itself. The countdown also referenced the ATLAS observatory from Fallout 76, which is strongly implied by terminal entries and dialogue with the Brotherhood expedition occupying it to have housed an experimental Weather-Control Machine.

The obvious conclusion? The Brotherhood is seeking to find and take control of a similar device in LA, to weaponize it against the NCR, while other groups, including the protagonists, are seeking it out as a means to bring vital rainfall to the infamously parched southwest.

  • Jossed. The artifact is a cold fusion generator able to provide infinite power at no cost.

What scientific experiments will Vault-Tec be conducting in the shows Vaults? And how will it impact the plot & characters?
Every Fallout fan knows that the true purpose of the Vaults was not to protect the American People in the event of Nuclear War, but rather to conduct unethical science experiments on unsuspecting civilians. It's practically guaranteed that Vaults 32, 33,and 4 are in the show, along with any other Vaults that may appear, will have experiments on their own populace. So this raises the questions: what will they be?
  • Theory 1: Lucy's Father (being the Overseer) will be involved with the experiments, and will likely be one of the antagonists in the show. Practically every Overseer in the Fallout series has been morally bankrupt or Punch-Clock Villains, with very few being upstanding figures. While we do see him behind glass in the trailer looking at Lucy, we don't know if he's making a Heroic Sacrifice or is finding himself at odds with his daughter as a result of the experiments.
    • Confirmed. Lucy's father, and all the Overseers before him, were cryogenically-frozen Vault-Tec management from a third vault, Vault 31.
  • Theory 2: Vault 33's experiment will involve drugs or something that affects the residents' minds. We do see a violent riot within the Vault during the trailer, with bullets flying & a woman with a fork in her eye wildly shooting an SMG. Its likely this will tie in with the possible experiment within the Vault.
    • Jossed. The "riot" was actually an attack by raiders pretending to be vault dwellers from a neighboring Vault that Vault 33 periodically swaps members with to help genetic diversity.
  • Theory 3: Vault 32, or the Vault with the One-Eyed Cyclops Resident, will be studying mutations. Perhaps Lucy travels to Vault 32 looking for help (like in Fallout 1 with the Water Chip), but is surprised to see what happens to the residents, who may have been deformed by the radiation, FEV, some experimental treatment, or even all of the above. Hence why the Resident has only one eye in the middle of his face.
    • Partially Confirmed. The project of Vault 4 was "what sort of society would one made up entirely of scientists with no ethical restraints build?" The current day residents of Vault 4 are the descendants of the test subjects of that vault, who rebelled against the scientists who experimented on them, as well as refugees from the surface who fled there after the destruction of Shady Sands.
  • Theory 4: Everyone in Vault 4 is dead. Of the confirmed Vaults, Vault 4 is the only one who we haven't seen the inhabitants of in the present day. Perhaps they were subjected to a more dangerous experiment that got everyone killed.
    • Jossed. the man with the eye is from Vault 4. A vault where everyone is dead does appear, however — the residents of Vault 32 destroyed themselves after learning the true nature of the experiment being run on them.

Full Episode Flashback about the Ghoul
Eventually, an episode will depict Cooper Howard's survival in the immediate aftermath of the Great War and presumably his wife and daughter's deaths. He struggles to survive and is forced to kill someone for the first time in self-defense. Also shows the beginning of his Descent into Addiction to chems and physical transformation into a Ghoul, including his hair falling out and skin peeling off.
  • Flip-Flopped. The Ghoul's story is doled out over the course of the series, with greater or lesser prominence. We mostly learn about what he got up to in the years leading up to The Great War. His descent into addiction happens because ghouls in the show use chems to stave off going feral.

Publick Occurences will be mentioned

There will be a few references to Fallout 4

  • Partially Confirmed, but mostly only visually — the actual events in the Commonwealth aren't touched on.

Todd Howard, another Bethesda higher-up or a Fallout 4 voice actor will make a cameo
Furthermore: at some point, someone talking to Cooper Howard says something along the lines of "Hey, you're Todd... no, Cooper Howard."

A Fallout 4 ending will be canonised
  • Jossed. The events of the game are never mentioned.
  • Well, partially confirmed. The presence of the Prydwen rules out the Railroad or Institute endings because it was destroyed in both. This leaves only the Minutemen and, of course, the Brotherhood endings available to be canon.

The Courier used the nuclear weapons at the end of Lonesome Road against the NCR.
The NCR seems to be in a weakened state compared to what we've been told of it before, and a prominent sign showing the "Shady Sands Public Library" sits right before a massive crater, seemingly implying that the capitol of the NCR isn't there anymore. The most likely source of such a disaster would be the Hopeville missile silos that the Courier gained control of at the end of the Lonesome Road DLC, indicating that the Courier may have gone for the Wild Card route in the most extreme manner possible.
  • This may result in the Courier becoming the Big Bad of the series.
  • It seems quite unlikely, since the Fallouts don't usually canonize bad endings.
  • Jossed. Vault-Tech is behind the destruction of the NCR, nuking Shady Sands sometime after New Vegas so as to remove a competitor to their scheme to Take Over the World.

A character would be heavily implied or confirmed to be the Lone Wanderer, the Courier or the Sole Survivor
  • Jossed. At least as of Season One.

The Legion will appear or be mentioned
  • Jossed.

The Legion will force an Enemy Mine between the Brotherhood of Steel and NCR
  • Jossed.

Elon Musk will have a cameo
Doubtful, considering that the series is on Amazon Prime, which is owned by Jeff Bezos whom he has a rivalry with.
  • Jossed. Elon Musk does not show up, nor does anyone who bears a lawyer-friendly similarity.

One of the three heroes will die at the end of the season

A character will turn out to be a Synth
  • Jossed for Season One. No one is revealed or implied to be a synth.

A Fallout companion will appear or be mentioned
Possible ways:
  • Clover became a mercenary and found herself in California.
  • Butch DeLoria finally formed the Tunnel Snakes gang and expanded to California.
  • Star Paladin Cross joined the Caswennan to California.
  • Craig Boone rejoined the NCR.
  • Veronica Santangelo reunited with the Brotherhood in Nevada or California and and rejoined them.
  • Piper Wright tagged along with the Brotherhood as a wartime correspondent.
  • Enamoured by the Brotherhood's brutality, Cait joined the Brotherhood as an Initiate.
  • Curie, whose Synth identity the Brotherhood are unaware of, joined them to serve as a medic.
  • Deacon infiltrated the Brotherhood planning to destroy them from within.
  • X6-88 escaped the Institute's destruction and plans revenge on the Brotherhood.

Lucy is the Ghoul's distant granddaughter
It's possible that for whatever reason Cooper Howard's daughter made it into Vault 33 but he didn't. In the present, he discovers that Lucy is his direct descendant.
  • Jossed. The Ghoul and Lucy are very definitely not related. Her father was alive at the same time as Cooper Howard, and was part of Vault-Tec's management, which was cryogenically frozen.

Episode 1 opening
The very first episode begins with Cooper Howard filming a commercial for Vault-Tec. We see his family and a bit of life in 2077 before cutting to the present in Vault 33.
  • Jossed. He and his daughter are performing a cowboy routine at a birthday party when the bombs drop. The Vault-Tec commercial is shown at the beginning of an episode, and that episode does revolve largely around The Ghoul's pre-War life, but it isn't the first episode.

The Mysterious Stranger appears
  • Jossed. No one matching The Mysterious Stranger's appearance or MO appears.

Shady Sands was destroyed by a nuke
The Brotherhood of Steel regained power on the west coast by setting off an undetonated nuclear bomb in the NCR capital, similar to the one from Fallout 3.
  • Confirmed, but it was Vault-Tech, not the Brotherhood, that nuked Shady Sands.

Lucy loses her Pip-Boy
By the end of Season 1 her Pip-Boy is somehow destroyed or stolen, symbolizing her distancing herself from the Vault.
  • Jossed. She still has it, even at the end after she's learned the Awful Truth.

Maximus defects from the Brotherhood of Steel
  • Played With. By the end, Maximus is willing to defect from the Brotherhood to follow Lucy back to Vault 33, but circumstances prevent it from shaking out that way.

The Enclave will appear
Confirmed! In the first episode, The Brotherhood of Steel as well as some bounty hunters are both trying to hunt down an ex-Enclave scientist on the run

    Pre-Season 2 guesses 

Ghoul Vials Origins
The vials that keep a ghoul from going feral are extracted from ghouls. This is why the drug dealers had several ghouls caged up, and why The Ghoul eats parts of his old friend after mercy-killing him, he's out of vials and he knows he can get enough to keep going from the flesh of another ghoul.

Her name really is Goosey
The records in Vault 4 are correct and she was originally named Goosey, but her father never liked the name and changed it in the Vault 33 records after he killed her mother.

Mr. House won in New Vegas
  • Unknown. New Vegas appears briefly at the end, but it looks like something terrible happened to it, so if he won it wasn't a long victory.

The Enclave were ultimately pawns of Vault-Tec and their goals
The Enclave's plans for mass genocide were all tied to plans by Vault-Tec to destroy humanity so the people chosen by Vault-Tec could inherit what remains. The series makes it clear that Vault-Tec only wants what's left of America for themselves, and won't share it with any power in the wasteland given how they crippled the entirety of the NCR by way of nukes during the time between Fallout: New Vegas and the series proper. While the Enclave were always evil and extremely fascist, as well as complicit in Vault-Tec's experiments, it could be argued that at one point they wanted to secure their power over America at all costs rather than destroy the whole world. In fact, even the lore for the games make it clear that the Enclave never fully adapted the plans for global genocide until the 2100s. This can be seen in Fallout 76, when the majority of those in the Whitesprings Bunker voted to reject Eckhardt's mad plans to destroy China at all costs, resulting in him killing the majority of the bunker to push his plans unopposed, and the fact that the Enclave is alluded to be actually aiding the Responders in Applachia despite being complete moral opposites to them, albeit for their own goals. The TV show implied that pre-war US government(which would already be pretty fascistic and Enclave infiltrated by that point) was willing to hear out peace talks with China despite their rampant anti-Communism, if for pure self-perservation purporses, and this scared Vault-Tec executives along with the fact that it is heavily implied throughout the franchise that the US would have collapsed eventually due to how bad things were internally, which might put Vault-Tec in a far more precarious position than if an apocalypse directed by them were to occur. It is quite possible that somewhere between the events of 76 and Fallout 2, the Enclave was slowly influenced by Vault-Tec via the connections both groups have with each other to adapt a policy of wiping the Earth clean by way of total genocide of everyone outside, eventually becoming what we know them to be by Fallout 2.

Fallout: Dust will be made Canon
With New Vegas seemingly in ruin as seen in a final shot of the season finale, the game mod or at least elements of it will be incorporated into the series and thus fallout's timeline as Ascended Fanon.

Character Sexuality Headcanons
  • Lucy is Bisexual, noting some subtle implications in the first episode she's previously had sex with both male and female vault dwellers.
  • Maximus is Asexual, although part of it being that like many of the Brotherhood's Aspirants he is very unfamiliar with sex to begin with.
  • The Ghoul/Cooper Howard is Straight.

The Enclave will return
With Vault-Tec still being in operation of some sorts and manipulating events across the wasteland, such as the nuking and destabilizing of the NCR, as well as being one of the many companies that helped to form the enclave to begin with. The Enclave will see a massive resurgence and perhaps even becoming the Big Bad of later seasons, this time with Vault-Tec at the helm leading it.

The New California Republic is still around, just weakened
While Shady Sands has been destroyed and the LA Boneyard seems to be firmly under Brotherhood control, the NCR had numerous cities under its control, so it's unlikely they were all destroyed unless far more bombs were used. More notably, the explicit reference to Shady Sands being the first capital of the Republic on the billboard, rather than the capital, and the reference to the "Fall of Shady Sands" happening both before the bomb and before Fallout: New Vegas all make it seem likely that a lot of command infrastructure was moved to a different capital long before the city was destroyed. It's entirely possible that the NCR still holds territory to the north or south, or possibly even in the Mojave Wasteland, even if New Vegas seems to be in a sorry state.

The Courier died or will be missing
The Courier could easily be a Story-Breaker Power even if they just go off of his (or her) cannon achievements in the base game with only The Ghoul being able to possibly give him a challenge. Also it would be very difficult for them to satisfyingly portray the Courier. Their easiest solutions will be to either have the Courier die or perhaps stranded in Big Mountain.
  • A Courier who ran off to do something important and keeps getting referenced by people the already-introduced cast meet around New Vegas would make for an interesting Big Damn Heroes moment if they return to save the day in the finale. Have them in full NCR Ranger armor the whole time with a power-armor-style voice distortion so you genuinely can't tell what they look like or what their gender is.
  • That said, apart from Fallout 2 where you play as a descendent of the first game's protagonist, the writers usually go out of their way to never mention any player character. So odds are, if the Courier is ever referenced in the show, it will be in an indirect way like Mr New Vegas does during his news segments.

New Vegas' NCR Ending is Canon
In the final shot of the season, we see the New Vegas Strip... and it doesn't look great. Sure, maybe it's just not dark enough yet for the lights to be on, but it might also be because the New California Republic ending of New Vegas is canon. Consider that the NCR was already stretched to its breaking point trying to hold Hoover Dam. Then the Courier arrives, kills Mr. House, helps defeat the Legion, and hands them control of New Vegas. Great!

... Until Shady Sands gets nuked. We know there were factions within the NCR hoping to seize power, like the rich brahmin barons. With the capital suddenly wiped out, the Republic likely crumbled as everyone scrambled to regain control of the situation. That left New Vegas without NCR support or Mr. House's Securitron army. No wonder the city looks like it's in rough shape.

  • This could also be supported by the fact that the Brotherhood is much stronger in this show then it was in New Vegas. This seems to rule out the Courier siding with House since a requirement for doing so is destroying one of the last (and probably strongest) Brotherhood bunkers in the west. Also there's no mention of Ceaser's Leigion though it could have collapsed even with the Courier's help.
    • It's only the Mojave chapter of the Brotherhood that's destroyed. Lost Hills still exists (if maybe somewhat weakened after their war against the NCR) and they could have risen in power after the destruction of Shady Sands. Not to mention, as we saw in the show with the arrival of the Prydwen, they've received reinforcement from the Commonwealth.

The Courier either resisted Vault Tec or was backstabbed by them.
This is kind of an oddball guess but it could make sense. According to an interview from IGN (https://www.ign.com/articles/the-big-fallout-interview-todd-howard-and-jonathan-nolan-answer-our-burning-questions-about-season-1) Shady Sands was bombed right after the events of New Vegas. Also in the stinger New Vegas appears to have sustained damage and is apparently a safe haven for Hank Mac Lean. This means that most likely something (in addition to Hank's jealousy) from the events of New Vegas triggered Vault Tec's attack on Shady Sands. Consider the following. If the Courier sided with the NCR then they gave the largest known nation on the continent access to renewable hydroelectric power and possibly a major solar plant too. In addition to this in a good karma ending to the DLC Old World Blues it says that the Courier starts to reintroduce pre-war technology as they see fit. If this is the case then in the NCR ending the NCR could be on its way to matching the power of the pre-war US. This would be an obvious threat to Vault Tec's plans. They could have tried to then coerce the Courier into cooperating with them and when they refused Vault Tec invaded New Vegas or perhaps they just started with the invasion. Alternatively if a Bad Karma Courier took control of New Vegas and if Old World Blues is cannon then Vault Tec could have offered them a deal. That in exchange for turning on the NCR Vault Tec would allow the Courier to truly take House's place and rule the Mojave. Vault Tec could have then turned on the Courier once they thought the NCR was taken care of. This theory can be modified depending on what karma Courier sided with which faction.

The Dates on the Vault 4 Blackboard Are Wrong
The events of Fallout: New Vegas happened in 2281. The blackboard in the Vault 4 classroom says Shady Sands was destroyed in 2277. Now, someone nuking the NCR's capital four years ago seems like it would have been a big deal in the game, so that means one of three things: either the show makes New Vegas non-canon, which, as mentioned above, has been jossed; no one throughout the entire game thought to mention Shady Sands being obliterated; or the teacher wrote the wrong date on there for some reason. Maybe they were challenging their students to spot the incorrect date? Or maybe record-keeping got spotty somewhere along the way, and what was actually 2282 or '83 got recorded as 2277?
  • It could also be that the "Fall of Shady Sands" was a different, if connected, event and the bombing happened some time later. The NCR was suffering economically by 2277, so perhaps the city was in economic decline at the same time.
  • Times not aligning could also be explained by some groups using a lunar calendar and others using a solar calendar. 219 solar years is about 225 to 226 lunar years. Solar calendars are useful when people want to keep track of seasons for farming, Which isn't required during a nuclear winter and probably not in a desert wasteland and might be used by a wasteland courier. Vaults would probably solar years as vault dwellers of Vault 33 believe they will "save America".
  • Word of God from Todd Howard in an IGN interview[1] is that the date on the blackboard indicates the start of the NCR's downfall, not the year the bombs dropped. According to the interview, Hank's nuke likely hit Shady Sands shortly after the events of New Vegas.

Vault Girl appearance is based on Steph Harper
If Vault Boy is based on Cooper Howard it stands to reason Vault Girl is based on someone, and Steph Harper is from the correct time period and looks similar enough for this to be a possibility.

Anti-feral chems are normal chems
There's nothing special about the chems the Ghoul uses to avoid going feral. They work by providing the mental stimulation necessary to remain sane, so any chems work as long as they're stimulants. This is evidenced by the Ghoul indulging himself on chems non-discriminantly in Episode 4 and the same episode showing ordinary humans using the same chems for recreational purposes.

The NCR will come Back from the Brink
Moldaver's last wish to Maximus clearly made him question his loyalty to the Brotherhood and he's a former NCR citizen already. It would be fitting if the instrument of the Republic's rebirth was someone honored for having allegedly snuffed it out forever. As he and Lucy travel the Wasteland, they'll encounter isolated NCR remnants, connecting them for the first time in years. By the time the season ends, there will be a unified kernel of a restored republic forming to eventually retake the Boneyard from the Brotherhood.

There will be an Enemy Civil War between the Enclave and Vault-Tec
Given how the Enclave is still pretty much active in some manner, and how its interests seem increasingly at odds with Vault-Tec, chances are Season 2 will see generations' worth of squabbles boil to a head as they put their respective visions of a new world into action. All the while, the Brotherhood and the shattered remnants of the NCR plot a daring scheme to wipe both out once and for all.

The East Coast Brotherhood will make an appearance.
Odds are, the nuking of Shady Sands would have drawn the attention of Elder Arthur Maxson, launching an expedition to relieve his West Coast brethren and stop Vault-Tec in the process. Said expedition arrives by Season 2, though potential conflict surfaces within the Brotherhood on whether to follow Maxson and his plans for its future or stick to the old ways.
  • The airship that arrived in Episode 1 is the Prydwen, so some elements of the East Coast Brotherhood are already here to support the West. There still could be more on the way, but the main body of reinforcements has not fully arrived yet.

Lucy was supposed to be spared
Moldaver's plan was for Monty to keep Lucy occupied while they massacred the Vault 33 dwellers to keep her out of harm's way. Once Lucy realized he was a raider, and resisted Monty trying to restrain her, Monty, probably truly a raider as opposed to a an NCR refugee, chose to ignore Moldaver's orders.

Vault-Tec is responsible for the CPG massacre mentioned in Fallout 4

Thaddeus will become a Super Mutant
He was most likely given FEV by the snake oil salesman, which would explain his massive new Healing Factor. Since we haven't seen any Super Mutants yet, this would be a good way to introduce them.
  • Or in worst case scenario, he will resemble Harold from Fallout who became more like a ghoul before turning into a tree in Fallout 3.
    • Or he may have just been treated with Hydra, a canon chem from the game that temporarily allows you to regenerate mangled or severed limbs.
      • Given the Snake Oil Salesman's... eccentricities, it was very likely some horrifying combination of FEV and Hydra along with who knows what else. It is mentioned that radiation will no longer be a problem for Thaddeus, so being just Hydra is unlikely.

Thaddeus was treated with the same pre-war ghoulification serum that turned Hancock ghoul
In Fallout lore, it's mentioned that many pre-war entities did experiments on ghoulification, and one result was a serum that would induce ghoulification in normal humans. When Hancock talks about his past, he explicitly mentions that he became a ghoul through this pre-war drug. It's likely that the Snake Oil Salesman somehow got his hands on a batch of the stuff and that's what he treated Thaddeus with.
  • The ghoulification drug might also be the same drug ghouls take to prevent going feral. The drug might not only cause ghoulification, but also stabilize the condition.

The tunnelers reached the Mojave
This would explain the apparent abandonment of New Vegas. After whichever faction took control, the tunnelers arrived and began overrunning the Mojave, fracturing civilisation there.

Lucy will change from her Vault suit to another outfit
With the realisation of who her father really is, she might sell or discard the Vault suit to distance herself from him. That, and to find something with more protection. Possible outfits include:
  • A Brotherhood uniform, either scavenged, stolen or given to her by Maximus. This may also let her infiltrate the Brotherhood. Alternatively, she may end up actually recruited by the Brotherhood and given a new uniform.
  • NCR military armor, possibly NCR Veteran Ranger armor.
  • A Tunnel Snake outfit.
  • A Sweater vest and slacks.
  • A Greaser jacket and jeans.
  • A Letterman's jacket and jeans. Possibly resembling the one Purnell's character wore in Yellowjackets.
  • An outfit resembling Piper's coat.

Lucy will become a darker and more amoral character
If she goes off the deep end, it may give Purnell to let off her inner Jinx a little. This may come hand-in-hand with the Ghoul taking a level in kindness.

Hank and/or House will make a We Can Rule Together offer to Lucy

Betty is Janey
Although very unlikely, since we see a pre-war Betty as a Vault-Tec secretary.

The really stupid Vault experiments were all Bud's fault.
He's certainly got the necessary personality traits to think it hilarious to make sure Vault 69 had a population of 999 women and one man. Or think having a vault populated solely by one man and a crate of puppets was a good idea.

Vegas Fell because Lake Mead dried up
In the final shot when we see New Vegas we see the city destroyed and several Deathclaw skeletons, but when Hank is overlooking New Vegas we can see everything around, what appears to be a small settlement, ect but on the right of the screen appears to be a crater but New Vegas was not hit, not anywhere close that is the dried up lake Mead, as such as things got desperate, as New Vegas used up the last of the water the Deathclaws attacked the city in search of water and prey.

The Ghoul will get another fandom meme moment like S1's "Golden Rule of the Wasteland"
The easiest way would be by him expositing to Lucy about what happened in New Vegas during the game's events, rattling off a quick description of the various factions involved and ending it with "and one fucking mailman".

Mister New Vegas will still be there.
Wayne Newton yet lives, and his cheesy smarm was almost as beloved as Three Dog's enthusiasm. Maybe Erik Dellums (who played Three Dog and has voiced an interest in being in the show) could play someone who's investigating just who and what he is due to how long he's been on the air. Is he a Securitron with a unique personality? An AI in a computer hooked to a radio tower? A Bud-style Brain On A Roomba? Literally just Wayne Newton, having taken the Cabot immortality serum centuries ago?

Vault-Tec will destroy the Prydwen
And make it look like one of the other California factions did it. Prompting the crippled Brotherhood of Steel to spend their remaining manpower on a retributive campaign and clearing the stage again.

Mr. House will be revealed to be behind Vault 11

I do not honestly want this theory to happen since it will decisively destroy a good chunk of the nuances surrounding this character but given that the finale implies that House was a far more sinister figure than New Vegas envisioned him as, the commitment of the showrunners to the "anti-corporate satire" of the series regardless of the debate around whether Bethesda truly abandoned the satire or not, the fact that the various experiments were divided up between the various companies, and the contempt House had for democracy despite the fact that the US pre-war was a fascistic oligarchy, it could very well be that the most horrifying Vault Experiment ever conceived was done so by him to create a situation that would "discredit" democracy and justify the existence of more heavy-handed rule in the Mojave using the data that the Vault gave him.

A much older Colonel Autumn will Show Up as The Atoner for the Enclave

The fact that the Prydwen shows up shows the showrunners are willing to work with a set canon, which opens the possibility of him appearing despite his fate being determined by a speech check. He was always one of the least genocidal of the Enclave top brass even after the Enclave shifted their goals to destroying all life on the planet, and could be legitimately read as genuinely horrified by Eden's desire to fulfill these aims. If the theory that Vault-Tec influenced the Enclave into pursuing their global genocide plans so they can rule over the remains turn out to be true, it could shatter his faith in what he strove towards even further. He could end up being an Iroh-esque exile(or alternatively a wanderer similar to Zuko in that episode where he wanders around the Earth Kingdom) seeking to atone for his crimes or even end up being to the Enclave Remnants as to what Pellaeon was to the Empire in the Star Wars Legends EU and turn what remains of the organization from militaristic fascists to perhaps an organization that accepts America is likely not going to be reunified, but seeks to protect or preserve traces of the good parts America's heritage across the wasteland for future generations to learn from.

Perhaps mirroring/contrasting the above, the Brotherhood will turn into a more villainous, or at best Ambiguously Evil faction

Regardless of the above WMG happening or not, Fallout 4 has shown a more darker side to the Brotherhood with their outright imperialistic expansionism into the Commonwealth and their anti-mutant sentiments coming to the forefront(through not as extreme as the Enclave). While some have argued that this is less the Brotherhood becoming a darker faction and more of a Character Rerailment from their Knight in Shining Armor in Fallout 3 portrayal to how things would be if the traditionalists(known as Outcasts in Fallout 3) reasserted themselves, the Brotherhood were traditionally isolationist and focused purely on technology hoarding rather than expansionist regardless of their xenophobia, whereas Fallout 4 shows them building a small Empire in the west coast of sorts. The existence of the Prydwen in the series heavily hints to the Brotherhood still being active in the Commonwealth if not outright victorious there, which could potentially legitimatize the imperialistic expansionism that happened under Maxion. In addition, the more darker interpretation of the Brotherhood started by Fallout 4 continues in this series, with hints that Maximus staying with the Brotherhood and them getting their hands on the Cold Fusion technology might not entirely be a good thing, and it could be developed even further in later seasons.

Lucy or the Ghoul will betray and abandon the other
Possibly while, after or just before the Ghoul is about to do something particularly reprehensible.

Lucy have her hair shaved to a buzzcut or pixie cut

Yes Man is still around in New Vegas
Whether the Independent ending is canon or not, he could show up as the city’s last remaining resident, and choose to help whoever meets with him first (probably Hank).

After his divorce, Cooper's daughter was replaced with a clone while his real daughter went into a Vault with Barb.
Somehow Cooper found out, which is why he believes his daughter is still alive.

The serum Thaddeus drank is actually a strain of the FEV from 1, 2, and 3.
Since ghouls are made from being exposed to near lethal amounts of radiation, and as far as we know, not from vials strangers give you, if could be assumed that the vial the snake oil salesman gave Thaddeus was actually a strain of FEV, and Thaddeus will turn onto a super mutant some time soon.

Hank will try to kill Lucy

Lucy will kill Hank

Ulysses will be given the role Courier 6 had
As the Courier originally intended to take the Platinum Chip to House, it makes the most sense for the writers to run with that plot to avoid having to portray a player character. Ulysses also being the instigator of the initial conflict by finding Hoover Dam, he's going to be involved in season 2 regardless of which ending the writers go with.

Fate of the factions/location/companions
  • Boomers-After the drying up of lake Mead the Boomers along with New Vegas were more than likely have the last remnants of water in the Mojave, they were overran by deathclaws with possibly the young and old escaping of the Bomber, maybe being a reference to Mad Max 3 after the plane crashed and the survivors being only children
  • The Kings-Destroyed by deathclaws
  • Great Khans-Still active, possibly new chapters and tribes scatter a crossed the wasteland
  • Caesar Legion-After the defeat at the damn, and possible Death of Caesar himself the various 87 tribes torn apart the Legion as various leaders vided for power causing a massive civil war, resulting in various fiefdoms and tribes to become raiders once again.
  • Follower of the Apocalypse- Still active
  • Goodsprings-Still inhabited since they had a well
  • Primm-Still inhabited
  • Nipton-After the Legions raid on the original inhabitants prospectors would attempt to scavenge things left over, with most of the infrastructure intack new inhabitants would move in restarting the town.
  • Novac-Fair enough away from New Vegas that the hordes of Deathclaws would ignore the settlement so it would be still inhabited.
  • Jacobtown-Still active, being up in the mountains the Deathclaws could have been unaware of the town as well as all the snow could allow water to still be accessible
  • Arcade is now leader of the Followers, possible helping the survivors of New Vegas
  • Boone could have died in the defense of New Vegas, or still be alive back in Novac
  • Lily is still in Jacobtown
  • Raul is died in the defense of New Vegas, or left New Vegas
  • Cass is still alive
  • Veronica has left the Brotherhood, regardless of previous quests since they've become more aggressive
  • EDE is now in the hands of the Remnants
  • Rex died in the defense of New Vegas

Regardless of the New Vegas ending, House still exists in some form... and will not be happy with Hank.
Given the current state of New Vegas, House might not be doing so well, allowing the writers to keep the true victor of New Vegas ambiguous, perhaps by claiming that an emergency backup system kept Brain Upload of his personality online if his body was ever destroyed so his true cause of death can be kept in the shadows.

More importantly, though, Hank is clearly heading to New Vegas with the intention of finding allies or useful technology, perhaps believing that House was on-board with Vault-Tec's plan. Unfortunately, House might have been a cold-hearted megalomaniac, but he was very much a pragmatist and wouldn't have been amused to discover that Hank's nuking of Shady Sands had cut off revenue to New Vegas and ruined his plans for space colonization. So, one of the biggest points of season 2 will be House being rediscovered in some form or brought back online in the belief that he'll help Hank... only for him to turn the tables on Hank at the very moment when he thinks he's safe, maybe even siding with Lucy just so he can take revenge on the man who wrecked his plans - even if costs House what remains of his unlife.

Cleric Elder Quintus is a former Legion member, one of their Scribe equivalents, or a sympathizer.
He gave the kid adopted by the brotherhood: Maximus, a Roman name. The BOS insignia is also remade into gold and red.
  • It is also possible that Maximus was himself born into the Legion. Either his family integrated into the NCR or he was adopted by an NCR family before being rescued by the Brotherhood after Shady Sands' destruction.

The Snake-oil Salesman is actually the Courier.
The craziest, least moral person present, yet he's crafting a magic ghoulification potion.'

In one of the great ironies the franchise loves, he'll be dunked in FEV but Vault 4's scientific knowledge will prevent him from going murderously insane - but not remembering a thing apart from his pleasant managerial manners. He'll end up helping rebuild Shady Sands while blissfully unaware his previous self destroyed it.


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