- Cross-Dressing Voices: Averted with Cody who's voiced by a child actor Troy Davidson, but played straight with Cody's friend Jake, who was voiced by voice actress Kath Soucie.
- Keep Circulating the Tapes: To date, there have been little to no home media releases, primarily due to the series rights being tied up between Disney (owner of ABC) and CBS (owner of distributor King World). The series did air on ABC sister cable network Toon Disney for several years, so at least there were reruns.
- Name's the Same: Saddle Sore shares his name with an in-universe cartoon character from the Biker Mice from Mars episode "So Life Like", who was coincidentally also voiced by Jim Cummings.
- No Export for You: There was a Mexican Spanish dub produced, but it was only broadcasted in a few Latin American countries and the series itself, oddly enough, was never broadcasted in Mexico despite being dubbed there.
- Playing Against Type: You know who co-produced this show? KingWorld. As in, the people who distributed Wheel of Fortune, Jeopardy! and The Oprah Winfrey Show, and who rarely produced shows themselves. The only other kids programming they distributed was The Little Rascals, so it's bizarre they got involved (perhaps it's because rival Group W/Westinghouse was distributing Teenage Mutant Ninja Turtles (1987), which was airing on CBS. If it was, then there's lots of irony involving that- CBS, which merged with Westinghouse in 1995, acquired King World in 2000).
- Similarly Named Works: A really bizarre example involving the already mentioned Mexican Spanish dub, as that dub was named in Latin America as Las vacas vaqueras (Cowboy Cows). It shares the same name with the Latin American Spanish title of Home on the Range, and considering how obscure the dub of this series was in Latin America, it's very likely Disney didn't know about the existence of a similar named series in that region.
- Talking to Himself:
- What Could Have Been: More episodes were planned after the second season, but were never completed.
- The Wiki Rule: The Wild West C.O.W.-Boys of Moo Mesa Wiki.
Trivia / Wild West C.O.W.-Boys of Moo Mesa