- All-Star Cast: Johnny Depp as Rango, Bill Nighy, Alfred Molina, Abigail Breslin and Isla Fisher to name a few.
- Billing Displacement: Abigail Breslin is billed pretty high in the credits (third or fourth) despite Priscilla not even really playing that much of a significant role in the movie. Granted, the film otherwise boasts few name actors than the ones listed above.
- Enforced Method Acting: Before the animation process began, Gore Verbritski filmed a live-action version of the film on a sound stage with very basic sets and props. The actors' lines were captured with boom mics and both their physical performances and the camera blocking were heavily referenced for the animation.
- Fake American:
- Isla Fisher as Beans.
- Bill Nighy as Jake.
- Fan Nickname: Fans have dubbed the canonically nameless hawk Metalbeak.
- One-Book Author: Industrial Light and Magic's only animated feature as an independent company. Their second, Strange Magic, was distributed by Disney after it acquired their parent company Lucasfilm.
- Relationship Voice Actor: Johnny Depp and Bill Nighy are once again fighting against each other.
- Talking to Himself: Johnny Depp does the voice of both Rango and Raoul Duke's cameo.
- Throw It In!: The first lines Rango says in the film? That's Johnny Depp warming up.
- The Wiki Rule: Yup, there's one.
- How many Academy Awards does Clint Eastwood have? Five. How many 'golden guardians' does the Spirit of the West, an expy of The Man with No Name, have? Five.
- Rango's name, despite being Durango without the Du, is most likely a reference to Ringo, the main character of A Pistol for Ringo, an Spaghetti Western staring Giuliano Gemma. It's also only two letters off from Django.
- Appearing as Lotso in Toy Story 3 and the Mayor in this film means that Ned Beatty was in two Academy Award-winning animated films in a row. In both cases, he plays the Big Bad.
- Famed cinematographer Roger Deakins was the responsible for the film's unique look.
Trivia / Rango