- Career Resurrection: Both this and fellow 1997 film Conspiracy Theory brought back Julia Roberts from a temporary dry spell in her career.
- The Danza: Julia Roberts playing Julianne Potter.
- Playing Against Type: The movie starts out passing off Julia Roberts in her usual rom-com role...until it becomes clear later in the film that she's actually the Villain Protagonist. This sleight-of-hand is basically why the film works.
- What Could Have Been:
- The original ending was to have Julianne meet up with a man at the wedding portrayed by John Corbett who she would fall for, but test audiences despised this scenario so it was not used.
- Sarah Jessica Parker was offered the role of Julianne, but was busy with her upcoming starring role on Sex and the City.
- Julia Roberts had selected Dermot Mulroney and Cameron Diaz as the actors in the film. Others in contention for the roles of Julianne, Kimberly and Michael include Calista Flockhart, Drew Barrymore, Laura Dern and Brendan Fraser.
Trivia / My Best Friend's Wedding