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That One Boss / LISA

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  • Joy mutants are devastatingly powerful and almost always come with at least one perma-kill attack. Thankfully, a majority of them are optional on Normal mode... except for Charmy, who is fought in Area 1. Charmy can easily one-shot pretty much anyone in your party that isn't Brad, and has a mountain of HP, especially this early in the game. The extremely limited roster of party members doesn't make this fight any easier, and while it is possible to grind on the snakes and shadowy figures in this area, doing so quickly becomes inefficient. While it might seem smart to just unload on Charmy with firebombs, doing so makes the Men's Hair Club much tougher to handle.
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  • If you enter Factory Town, when you come out, you'll be ambushed by the Road Scholars, who will demand all your mags. If you choose not to give them up, then you get sucked into a fight with a five-man gang. They all have very respectable HP and can hit ridiculously hard for this stage of the game, and worse yet, several of them can Stun or Paralyze your party members. Often, this ends with the five of them whaling on your helpless, immobilized party. Even worse, Crack Ripper, the leader, knows a perma-kill move, and will start using it if you drag out the fight too long. About the only way to win this fight is to know it's coming and either bring Firebombs, grind Brad up enough to use Head Slide, or just fork the mags over. Losing this battle will result in the town getting blown up, along with the powerful party member Mad Dog. Oh, and don't try to be smart and spend all of your mags beforehand; the Road Scholars will just blow up the town without a fight.
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  • Kim Sex Machine. You'd think a male exotic dancer would be wimpy, right? His HP is pitiful, his defense is nonexistent, his attacks aren't likely to scratch you, and, oh yeah, he's packing two perma-kill moves. Even worse, since he has a tiny movepool, he's likely to get at least one off if you can't kill him almost immediately. Thankfully, he only fights you if you're a jerk to him.
  • In Normal Mode, Sweet Tea Rakeem is a forgettable early game boss. In Pain Mode, however, he gets a friend - Vic Cherry. While they don't hit as hard as mutants do, they hit much more consistently, and their damage output can quickly become overwhelming. Oh, and they both have a small chance to use perma-kill moves.
  • The two required Joy Mutants that are only fought on Pain Mode, Herb and the now-mutated Hawk, are especially frustrating due to the fact that, barring the basic Joy Mutant bite attack that they use more, overprioritize their perma-kill moves, meaning that it is very likely to see your party members be quickly picked off until they begin to wail on Brad. That, and they are not only immune to Fallen, but Paralysis and Scared as well, meaning you will NOT be able to catch a break with either of them.
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  • Peter. He has pretty solid HP and is tied with Wally for having the second highest Attack stat (and the highest of any required boss), meaning that he can easily KO a party member with ease. But that's not all; he comes with not one, but two perma-kill moves, and he loves using both of them, so have fun trying to keep all of your party members' heads on. Oh yeah, he's required on all routes. Peter's only saving grace is that his Agility is practically nonexistent, but he's still a very powerful killer.
  • Wally. Wally has three forms, each of which packs 4-digit HP (which, when added together, gives him 19,000 HP; the highest of any required boss and the third highest overall) and fairly respectable defense with Fallen immunity on the side. Wally can also Laugh, which, while possible to miss, is more often than not capable of inflicting the entire party with Scared (causing the victim(s) to waste their next turn) and the seldom-seen Depressed (a ridiculously-crippling debuff that harms your Attack, Defense AND Speed) at once. Plus, during his third phase, Wally will not hesitate in using a perma-kill move on you, something that is especially bad if the target happens to be inflicted with either/both of the above debuffs. If you've run out of items and SP during the first two forms, then you're in for a beating.
  • In Joyful, Vega Van Dam is the lowest ranked living warlord on the list. Despite this, he's probably the hardest out of the first three to defeat. He's flanked by Fatty Peach Dog and Timmy Apple Cat, both of whom hit quite hard and have enough HP to weather several rounds of both Buddy and Rando's attacks. Vega himself can give himself the Super Cool status buff to heal 600 HP each round, as well as blinding Buddy and Rando with his smile. Fortunately, Vega is very weak to Flustered, meaning that once you get him alone, it's not hard to chain together Flash attacks and immobilize him.
  • Big "L" Lincoln in Joyful. With a massive HP pool, immunity to Flustered, and devastatingly powerful attacks, it's easy to see how Lincoln became the strongest of the Olathe warlords. Lincoln can give even a Joyed Buddy a run for her money, and that's all before he starts praying and healing himself. Lincoln is easily the hardest boss in the game, especially considering how easy the final bosses are.
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