- Cat from Cat and Girl is a major one.
- The eponymous character of Hanna Is Not a Boy's Name. Complete with Gender-Blender Name, natch. Notably, he is seen in an official guest strip making a face more commonly seen on Spongebob Squarepants ("FREEEEEE"), doesn't narrate the comic because he's too hyper, and has a Tall, Dark, and Snarky sidekick/Heterosexual Life Partner who does narrate (and is more than One Head Taller than Hanna). Hanna is not quite 5'3", has almost-fluorescent red hair, often dresses fairly colourfully, is quite the Motor Mouth, and is Older Than He Looks: as his bio says, he's "best described as an overly enthusiastic, obnoxious child in the body of a twenty four year old man." Except not exactly the body of a twenty four year old man, because he looks so young that nobody ever believes he's an adult.
- Kazuki from Kenshiro no Tabi, who upon imbibing triple-sweetened strawberry-milk released enough energy to create a nuclear explosion.
- Rocky from Lackadaisy. A skinny sugar addict smartmouth, Rocky's boundless energy combined with poor impulse control regularly gets him into trouble.
- Taisei from Sakana does fit the "hyperactive", "cheerful", and "loud" part, but he's not exactly small.
- T-Bob from Something*Positive, described in an early bio as "the living embodiment of caffeine."
- Pretty much deconstructed in The Quick and Dirty Life of Fritz Fargo. Fritz is five-foot-nothing, very emotional, very loud (he's a vocalist in a rock band), and very, very energetic. He also has a Heterosexual Life-Partner who's One Head Taller than him and twice as broad as he is, Anime Hair, a missing tooth that makes him look rather childish... and a really serious cocaine habit, which is why he's so hyperactive.
- Selby the spaniel from Woods For The Trees.
- Rudy from Rain is upbeat, effeminate and one of the younger members of the cast.