She is active in various progressive causes, notably reprising her role as Grace on the condition that Grace be a feminist.
- Ned & Stacey (1995-1997): Stacey Colbert.
- Seinfeld (1996-1997): Beth Lookner.
- Prey (1998): Dr. Sloan Parker.
- Will & Grace (1998-2006, 2017-present): Grace Adler.
- Jesus (1999): Mary Magdalene.
- The Mothman Prophecies (2002): Mary Klein.
- Hollywood Ending (2002): Lori.
- Along Came Polly (2004): Lisa Kramer.
- The Starter Wife (2007-2008): Molly Kagan.
- Smash (2012-2013): Julia Houston.
- The Mysteries of Laura (2014-2016): Detective Laura Diamond.
- Searching (2018): Detective Rosemary Vick.
- Bathing Beauty: The promos for Mysteries of Laura put a lot of emphasis on a scene in which she relaxes in a hot tub while wearing a green swimsuit with a plunging neckline. She's also posted some photos of herself in the bath to her Instagram account.
- Older Than They Look: She is fifty but you wouldn't know it from looking at her.