In general, defeating any member of the Metal Slime family is this, considering how annoying the little creatures can be. It takes a genuine amount of luck and patience to pull it off, but when you do, theres no greater sense of pleasure than to see the experience points pour in!
There's going to be a CGI movie based off of V called "Dragon Quest: Your Story" and judging from the beautifulVisual Effects of Awesome displayed in the trailers, it's going to be epic!