Is he a genuine friend who just wants to recover his old relationship with Ash? Or is he an obsessed vampire who embraced Ash just to force a relationship, whatever might be its nature, between them?
Does Issac truly belong with the Anarchs with his dislike of the Camarilla? Or is he really Not So Different from the Camarilla or a Prince? Do note that his first quest is him demanding tribute to stepping on his side of the street before he gives any information, sending the Fledgeling on a goose chase into several dangerous territories, including into the haven of a Tzimisce who are a Clan well known for inflicting Fate Worse Than Death at worst, and all the while not even lifting a finger to help...which sounds almost exactly like what Lacroix has done to the Fledgeling in the game and how a Camarilla Prince would normally behave.
Is VV a gentle vampire too kindhearted to resort to the occasional violence she knows is vital to preserving the Masquerade? Or is she, in true Toreador fashion, a Manipulative Bitch who emotionally manipulates young kindred into performing her dirty work for her?
Is Heather really in love with the PC? Or is she simply a drug addict acting the part so you'll feed her your blood? For that matter, how much of her feelings for the PC comes from the bloodbound messing with her mind and how much is genuine?
The final fight against Andrei the Tzimisce if you have the flamethrower.
The endgame. Assuming you were hoping to kill the Prince in something other than a cut scene.
Complete Monster: Andrei the Tzimisce, as Archbishop of the L.A. branch of the Sabbat, takes the Sabbat's ideals of embracing their inner beast and renouncing their humanity to a whole new level. Andrei lives in a house that he has decorated with body parts in order to make it resemble his ancestral estate. The walls are coated with bloodied human flesh and the furniture is made from bones and organs. Equal parts Evil Sorcerer and Mad Scientist, Andrei uses live people and vampires as materials in his construction of the monstrous abominations that serve as his soldiers. He then tests the killing capacity of these monsters by unleashing them on defenseless mortals, with his ultimate goal being to use them to wage war against the Camarilla. In particular he plans on wiping out the Nosferatu in order to "gouge out the eyes of the Camarilla." Also, should the player not send away their ghoul friend/lover, Heather Poe, then, upon reaching the Sabbat's lair, the player will arrive just in time see Heather brutally murdered by Andreis goons.
Cult Classic: The bugginess of the game as it was originally released put a dent in its popularity, but a dedicated fanbase has grown over the years, especially in light of recent patches.
Disappointing Last Level: The game is a very complex, ambitious and non-linear action/RPG with an intriguing, atmospheric story and multiple ways to solve the majority of the quests... until its last act, in which it drops the RPG part and becomes a somewhat hack-fest against waves and waves of enemies and obnoxious boss battles. In fact, while it is perfectly possible to complete most of the game with a non combat oriented character who focuses on - say - stealth or diplomacy but isn't particularly good with guns and swords, in the last chapters such character will probably get his/her ass kicked.
Notable for the contributing factors. Pretty-much all in-game signs point to the cab driver being Caine, but the developers, when questioned by fans, claim that there is no right answer, and the expanded-universe novel covering Gehenna puts Caine elsewhere. However, it's entirely possible he put himself there so Beckett would find him in a circumstance that would make him appear trustworthy, or... yeah, you can justify either point of view.
If you check out the folders associated with the game on your computer, all of the Cabbie's voice-files are sitting in a file labeled Caine. As for conflicting with the novel, it's worth noting that Caine is pretty much a vampiric God - disguising his appearance and seeming as if he were in two places at once would be child's play for him. If anything, it's possible that almost crossing paths with Beckett in LA is what prompted their later interaction in the novel...
He's the single most powerful vampire on the planet, besides the travelling issue, he could also very easily possess someone from halfways across the world and maintain it for long periods of time.
Some fans have suggested that Deb, from the radio show, is Kindred. This would explain a lot, since she'd probably be how the Camarilla (or the Anarchs) kept tabs on the various crazies. Note her reactions to Andrei and that one Conspiracy Theorist who manages to figure everything out, for the latter she gets unusually hostile at the guy, and for the former she says she has to "take care of something" and quickly goes to commercial after the call.
It is commonly suggested that Grout is alive. In particular: his corpse should have disintegrated completely considering how old he is, he can predict the future being a Malkavian and all, and the audio logs are scattered for someone to discover them by going through the front door, which faux-Nines didn't do. Conversely, the Malkavian player, when talking about Grout will make reference to "that name not being here" and that they shouldn't go, so Grout would have to be hiding from the Malkavian Madness Network too, which is unlikely since that reaches even Malks in Torpor.
Being a Malkavian. You begin with an innate bonus in Spotting. The three specific disciplines doesn't break the Masquerade when used outside and two of them are very very useful: Dementation (Hysteria) allows you to hypnotize most NPCs (replacing a persuasion attempt in dialog, influencing quest-related NPCs to do something stupid, or shortly freezing a single hostile NPC during a fight), and Obfuscate is basically a super enhanced stealth. Those two disciplines combined make the stealth-based missions a cakewalk (Obfuscate allows you to cross the entire "Blood Hunt" level without fighting!). And what is the drawback of being a Malkavian? No actual stat penalties, but only hearing voices and having weird lines in dialogs.
For even more gamebreaking, you can play a Malkavian with a specific historynote if you have the Unofficial Patch "Occult Nut", which has the advantage of greating more XP as quest reward and the drawback of limiting the highest charisma score to 3 instead of 5. So, with a maximum persuasion score of 8, a couple of dialog options would never be accessible, but this XP loss is largely compensated by the bonus XP granted by the mere possession of this backstory.
At higher levels, Fortitude makes you near invincible, especially if you have the body armor. With it, you can shrug off entire clips of Steyr Aug ammo and even normally hard-hitting bosses like Andrei's War Form and The Sheriff will barely hurt you.
The Flamethrower deals ridiculous damage with no firearms skill needed, and it stops non-monstrous bosses from attacking or using their defensive skills as long as they burn. Its only weakness is its lack of ammunition and the high cost of the fuel.
The Thaumaturgy Discipline, exclusive to the Tremere clan, is ridiculously powerful. Its starting ability, Blood Strike, is a homing projectile with a decent range that always damages, kills any non-boss in three or four hits, costs only one blood point, and - the kicker - restores two blood points to you after it damages most types of enemies. It's possible to wipe out an entire area with this ability and only end up with a net loss of one blood point. The second tier power, Blood Purge, affects almost all enemies, including several bosses. It costs only two blood points, and paralyzes enemies for several seconds by making them vomit blood. By the time they recover (assuming you haven't already killed them), the ability has long since recharged and can be used again.
The similarly functional (and Tremere and Ventrue exclusive) Trance skill, which only costs one blood, leaves your opponent completely defenseless for a good while, works on almost every boss, and will still daze them even if it fails! Not only can it be used to unload magazines of pain on bosses, it is also VERY useful for stealthy players. And to add icing on the cake, it erases recent memory from the target, meaning it can be used to neutralize any potential witness who threaten the Masquerade without having to kill them.
The Punch-Packing Pistol, the last pistol you can buy, is possibly the most accurate firearm in the game. And unlike the sniper rifle you can fire off multiple shots quickly before you need to reload.
You can get duplicates of skill books by selling them to a vendor and buying them back. Most books can raise your skills two levels, but only one at a time.
After the Point of No Return, the player character can only go to his/her haven, Vandal's bloodbank, Trip and Mercurio shops, and the two final levels. Except leaving the haven through the airvent instead of the door allows to still access the normal areas of the game. It's fixed by the Unofficial Patch.
Hiding in a certain place during the final boss battle will cause Chiropteran Behemoth to glitch out and stay floating in one place, allowing you to just shoot it until it dies.
Similarly, with Brother Kanker you can simple move behind the steam pipes and shoot him while he dances about unable to reach you.
Harsher in Hindsight: If you look on Simon Milligan's computer when you come to deal with him for Pisha, you discover that they were planning on shooting the next episode in the zombie-filled graveyard in Hollywood.
One of the offensive video games a news report cites as a target for political criticism is called 'Meth Tycoon.' In 2004, a popular work of fiction with a meth dealer protagonist probably seemed suitably over the top. A few years later...
Memetic Mutation: Discussion on Bloodlines online will eventually lead to someone saying "Time to re-install", with a demotivational poster explaining it perfectly: "Bloodlines: Everytime you mention it, someone WILL install it".
Similarly, discussing playing Bloodlines for the first time online will lead to people giving the obtuse advice "Don't open it."
Moral Event Horizon: LaCroix was presented as unlikable from day one, but you could still, to some extent, sympathize with him due to how little respect he got and the fact he remained more or less polite as long as you don't insult him. He however establishes himself as truly villainous when he tries to have Nines and your character killed by the Werewolves, then uses you as a scapegoat to cover his deals with the Kuei Jin, even if you have been nothing but loyal and obedient to him until that point. After this, trying to still support him regardless will automatically result in your character's death.
Any cutscene featuring the Player Character won't look nearly as serious or cool if you're playing as a woman due to how they're rigged to the same skeleton as a male character. Their animations look incredibly wonky, and they have a notably masculine way of walking.
The opening cutscene is supposed to be filled with a sense of tension, but it's silly when you see that Velvet has attended what's supposed to be a formal meeting in her stripper outfit.
The encounter with Samantha. Your character meets a friend/relative from when you were human, who apparently was worried sick about you, is happy to see you again, and intends to call the others to say she found you... and since this would endanger the Masquerade, you have to prevent her from doing so. Which you can only do by killing her, threatening her, brainwashing her into forgetting your encounter (which is only available if you are a Tremere or Ventrue), or pretending you are someone else, leaving her sad and disappointed. Not only are there no option to explain her the truth or convince her to be a Secret Keeper, but this suddenly makes you realize that, following their embrace, your character had to leave all their relatives and loved ones behind, without even getting to say them goodbye.
Gameplay-wise, not only are they the worst kind of Marathon Level, one which comes on the heels of a whole other level with its own boss fight, not only are they an unintuitive maze, and not only are there Goddamn Bats every few feet, Demonic Spiders every few yards, and Degraded Bossesin the same dungeon where they appear as proper boss fights, but there is no opportunity to replenish your blood supply through any of it, short of a rapidly-dwindling supply of rats. If you don't have either Pisha's blood-collection artifact or a generous supply of blood packs, you're going to be in a lot of trouble, very fast, especially if you're a Ventrue, who can't even use the rats. There are a couple of points at which you can leave the sewers to heal your wounds and replenish your supplies, but when the big selling point of a level is that you can get the fuck away from it, you know you've got a rare vintage of scrappiness.
From a narrative point of view, they constitute a dramatic end to the majority of the story- and character-based portions of the game, and an equally dramatic beginning to its long, slow, agonizing slide into endless combat, which continues without relief to the very end. Except for Chinatown, which itself is the shortest and least open of the main hubs.
The museum level as well. It's starts off rather simple until you get to the lower levels. Now you've got cameras that sound alarms if you get caught in their paths. You can disable the cameras by using the computer in the security booth, but there's a guard inside. If you don't have any Disciplines to incapacitate him without killing him, you're going to have a hell of a time trying to manuever around the cameras and the guards patrolling the area.
The Elizabeth Dane can be this if you were really unlucky with your skillpoint allocation. It isn't so bad if you're halfway decent in Persuasion and Hacking. You can persuade the first guard to give you the police report and call away another guard, then you just need to sneak into the cabin, hack the doors and the cameras, take the ledger and off you go. Without even coming close to another guard. And if you're a Nosferatu or a Malkavian, hence gifted with Obfuscate, even the sneaking portions aren't that bad.
Even without Obfuscate if you managed to persuade the first guard but screw up (i.e. take too long and the guard is back at his post) you can just run right by him, pistols aren't going to drop you that fast and you can still avoid killing anyone.
That One Level: The Warrens, a Marathon Level that largely serves as nothing but Padding. They're full of annoying and hard to kill monsters, tricky puzzles, and contain no interesting loot or anything importance to the plot. Thankfully the most recent versions of the unofficial patch re-implements a Dummied Out shortcut that allows you to skip the lower three levels.
That One Sidequest: Defending the graveyard from a zombie horde. There are literally hundreds of zombies, they take forever to kill, and the two gates you have to defend are very far apart, and you automatically fail if even one zombie breaks through. Let's just say that many players take up Romero's offer to get him a hooker (or have sex with him, if your character is female) just to avoid the sheer pain of the graveyard level.
The PC's sire. Going by estimates from lore fans based on the PC's traits and the tabletop rules, they were at the very least of below-average generation, possibly even stronger (most likely 7th). Yet, they're forgotten about shortly after embracing the PC, with none of LA's major vamps ever mentioning knowing them. Why this individual chose the PC of all people, why a seemingly experienced vampire would (no doubt knowingly) commmit such an obvious violation of the Traditions, who they were and what their allegiance or ambitions were, none of it is ever answered. Also falls into They Wasted a Perfectly Good Plot, given that this is Vampire, where whole storylines could spring from trying to dissociate oneself from a sire who has fallen from grace or the power vacuum that the destruction of such a vampire would create.
There are two other primogens at the primogen meeting in LaCroix's office, but you never get to interact with them.
Grout. Seriously, the head Malkavian vampire already being dead when you find him is going to make you feel very cheated.
Ugly Cute: Of all things, most of the Nosferatu you encounter. With a hood they could easily live in LA. The male PC Nosferatu is arguably the ugliest of them.
Mitnick the hacker Nosferatu looks like a perfectly normal 20-something aside from pointed ears and baldness. Some dialogue implies that Mitnick somehow became more attractive after becoming a Nosferatu. Which raises the question of how ugly he must have been before he was turned.
Even though female Nosferatu seem to be uglier than the male ones, Imalia's just bald and a funny colour.
Vindicated by History: While the game was considered to be a buggy and unstable mess at release and was such a massive commercial bomb that it sunk Troika Games, it has gone on to become a Cult Classic, with many praising its story and replay value. It helps that fan-made patches have done much to fix its many problems.