You wouldn't imagine that this game would have a lot of heartwarming moments, being about playing undead bloodsucking monster but you would be wrong. There's quite a few heartwarming moments.
The opportunity to save the life of Heather in the first act. A young girl crying out for her grandmother is dying of a hit and run. Encountered on your player character's first night as a vampire, it's entirely likely that they save a life as a vampire first rather than takes it.
It is especially touching when helping her as a Malkavian. So far in the game, odds are your character has acted like the typical Cloud Cuckoo Lander. However, when Heather wakes up and speaks to you after you've fed her your blood, you character can give a reply that actually sounds quite sane, telling her that you only wanted to ease her suffering. It actually quite a touching moment, showing that even the Malkavian PC can retain their humanity, even through the insanity.
As with most happy sidequests, you get an option to take the low-humanity approach and drive a wedge between the couple. Unlike the others, it doesn't work. The most you can achieve this way is E telling you to stick it.
Hannah the escort has fallen for a guy, not a client, she just met named Paul. Cursed with an incurable disease by the Plaguebearers, she doesn't know Paul is already dead. Your player character has the opportunity to Let Them Die Happy by telling them Paul sent them. If you're a Malkavian, you can even impersonate Paul with Dementation.
Your Malkavian can use his Dementation powers to make Heather believe her entire experience with you has been nothing more than a wonderful dream. This allows her to move on with her life and spares her a grisly fate, even as she'll spend the rest of her life dreaming about you her "Master of Dreams."
When the feuding Voerman sisters, having screamed, argued, pointed fingers, revealed themselves as split personalities, and tried to kill each other, finally reconcile:
The PC: You both must have gotten along at one time. Jeanette: Yes... there was a time. Therese: When I was a child... I didn't have many friends. I suppose Jeanette was the only one. We never did get to go out of the house much; Father wouldn't allow us- Jeanette: He said we'd get hurt. So we stayed inside and imagined our own worlds. And we spent so much time there, together, ruling over those places... those were- Therese: Happier times. Before we grew apart.
They do immediately threaten to kill you if you tell anybody about them, though. Ironically, this becomes faintly heartwarming in that for the first time in the story, the sisters speak in perfect unison.
Even more heartwarming is when you visit them later. They still argue, but it is far more friendly now. And they seem genuinely happy to see the PC again. If anyone feels the end game is depressing visit to the asylum will serve as proof that your PC did do good.
When you meet your friend, Samantha, in Hollywood, she starts exclaiming about how everyone thought you were dead, asking if you we all right, saying that everything will be fine, wondering if you have amnesia, organizing all your old friends from your mortal existence to get back together and try to jog your memory. You can persuade her not to make the call, which gives you a Masquerade redemption, but it feels surprisingly good to know that there are still people in the daylight world who care about you, and letting her make the call (while it puts a ding in your Masquerade violations) is heartwarming in that you still have one connection to the world of humanity.
Another occasion where the Malkavian can create heartwalming; you can keep the Masquerade without leaving Sam heartbroken. Instead she's overjoyed that she got to see her childhood pet turtle again.
Thrust into an undead life as a Vampire, saddled with an Inner Beast and a thirst for blood, surrounded by plotting elders, hordes of enemies human and super natural, and despite all the horrors the game throws at you, you can still end it with a Humanity Rating of 10 = SAINTLY.
The whole ordeal with Jack in the beginning is kind of sweet. He takes the time to show you the ropes of being a vampire, and depending on how you've played out, he'll return to help you out. He's like an undead big brother.
One of the most popular fanmade add-ons, Clan Quest Mod, adds an additional questline involving a sassy Kuei-Jin named Kalliyah, who wants you to take her out on a date. You and she proceed to tear up LA with her adrenaline-junkie antics as she explains what Kuei-Jin are and what they do as compared to Kindred - and as the night progresses, it gradually becomes more and more obvious that genuine feelings are developing between you. This, despite all evidence to the contrary that the undead are only supposed to truly care for one thing - feeding. It comes to a point where you defend her honor by killing two Camarilla underlings who attack her, and then the two of you consumate your relationship back at your haven. The addition of this quest makes it a lot easier to consider picking the Ming Xiao ending, even though she's a snake, though Kalliyah is constantly and openly contemptuous of the woman.