Played for laughs when Kenichi: The Mightiest Disciple hovers over his food when eating at Ryozanpaku, expecting his masters to pull the "eating is training" exercise seen in martial arts fiction. The masters actually had no intention of doing any such thing until Kenichi mentioned it and turned them on to the idea.
In Blood-C, when the Elder Barin is massacring Saya's classmates, one of them manages to react faster than them and get out. He then gets killed when hit by glass shards, caused by Saya jumping off the window.
In the "Total Drama" story, "Legacy", a certain contestant, who happens to be a slasher flick buff, is convinced that the serial killer is just an actor hired for the challenge, so she doesn't try to defend herself. Tragedy ensues as the story diverges from the canon moments later.
After a few moments of Dangerously Genre Savvy, Cooler slips up and suffers this in Dragon Ball Z Abridged. After launching his Death Ball at Goku, he starts ranting about how much smarter than Freeza he is and how he's going to avoid the same fate - without actually doing any of it.
Subverted in Galaxy Quest. A low-ranking cast member of the show is extremely Genre Savvy and constantly worries because he is the red shirt. In the end, he survives the real life drama and is promoted to an actual cast member when the show is restarted.
In the climactic final shootout, he is the only character to not get shot.
M. Night Shyamalan uses this in a Take That against film critics in the movie Lady in the Water. The critic is very Genre Savvy, to the point that (while tipsy from a party) he starts a one-sided conversation/lecture on his chances of surviving the movie's monster... while it's slowly advancing on him!
"Hello? Is the bathroom on this level working? A dog inside the building! Go! Shoo! Why you're not a dog at all. My god, this is like a moment from a horror movie. This is precisely the moment where the mutation or beast will attempt to kill an unlikable side character. But, in stories where there has been no prior cursing, violence, nudity or death, such as in a family film, the unlikable character will escape his encounter, and be referenced later in the story, having learned valuable lessons. He may even be given a humorous moment to allow the audience to feel good about him. This is where I turn to run. You will leap for me, I will shut the door, and you will land a fraction of a second too late."
[turns to run, and is promptly killed by the monster]
Randy Meeks from the Scream films, who was nearly killed in the first movie by a killer who was sneaking up behind him while he was watching Halloween (1978), berating Laurie Strode to look behind her. He wasn't so lucky in the second movie, but was Genre Savvy enough to leave a videotaped message to the survivors just in case they were living in a trilogy.
In the second movie, the two girls who survive the crash where the killer is driving both run to the end of the block. One then turns around to check and see if the killer was dead. The second girl insists that they don't go. "This is stupid! Stupid people go back! We're not stupid people, are we!?" The killer then appears behind her and stabs her while the girl who went to check gets away.
If Tatum in the first film stopped her rant about how obviously contrived her situation was (trapped with the masked killer) even a few seconds earlier to think, she might have been able to get the upper hand and escape.
She also thought this was an elaborate prank, so she said it with a tone that indicated she believed these events to all be ridiculously impossible. In fact, she breaks her own leg (and the bone shows, yeck!); the killer winces at that point. The irony was palpable.
For how oddly genre savvy Narissa is in Enchanted, she uses it in a way that ends up with her dead. By the time she has Robert in her clutches, scaling the building, it's blatantly obvious Edward and Giselle aren't joined at the hip any longer, and Giselle is not your average fairy tale princess. Now, had Narissa taken, say, Edward up the building, she might have survived. Assuming Pip didn't go after her anyway, or Nathaniel didn't go after him, being his lackey and all...
In House On Haunted Hill 1999 (1999 version), Chris Kattan's character, who knows the lethal history of the house, spends most of the movie sitting in the most central, well-lit room possible and drinking heavily. However, this doesn't do him much good.
Interestingly, in the original version of the script, he was the one who survived, while the black guy died.
In Dead Snow, horror film geek Erlend lampshades the students' "group of friends alone on a trip with no cell reception" situation as a horror trope, correctly identifies the zombies when they appear... and is one of the first to die.
In the slasher movie Halloween Night, the lesbian couple who just had sex are damn near an inversion of this trope since they made it to 3/4 of the way through the movie despite breaking pretty much every horror movie rule in the book. Still, at that point, the killer drops down in their room from....somewhere and goes up to their bed to attack them. The taller girl specifically never assumes that it's their friend, something damn near groundbreaking in horror movies and instead instructs her girlfriend to run while she beats the shit out of him. He likely would have lost this fight had it not been for the inexplicable clothes hanger that he put through her eye. Also her girlfriend escaped and was the one who called the police that showed up at the end.
Subverted in Jurassic Park, where Ian Malcolm, who has been predicting disaster from the start, is attacked by the T-Rex but survives. Played straight with Muldoon, who knows exactly how dangerous the dinosaurs are, and is killed by a velociraptor.
Around two-thirds of the way through Sinister, the lead well and truly realizes he's in a haunted house movie and takes his family and moves back to their old house. Unfortunately, it turns out that the big bad wants the families he affects to move out, as they'll leave behind a record in a new place and expand his influence.
In the novel Jurassic Park, Ian Malcolm from the very beginning states that the animals will escape and the park is dangerous, just because his calculations say it must. At every opportunity that arises, he repeats that the park is doomed. Naturally, according to this trope, he agreed to go to the park and thus dies there. Although it is later Ret Conned that he survives so he can be in the sequel.
In season 6 of Smallville, two characters (one played by a well-known rap artist, the other by a relatively unknown actor) are playing basketball when they see and hear something fall from the sky and land not too far away behind a warehouse. The character played by the rap artist immediately goes back to check it out, while the other tells him not to go there, yelling "Don't you ever watch movies?" Of course, the guy who goes to check it out ends up getting possessed by the alien that had just landed, while the other is reduced to ash a few moments later. In a way, this overlaps with Death by Pragmatism.
In the episode "Exit Wounds" of Criminal Minds, the Victim of the Week heard a noise and called out "Who's there?" She immediately lampshades this by adding "Right, because the homicidal maniac hiding in the shadows is totally going to answer you." He doesn't.
In the play and movie Arsenic and Old Lace, Mortimer is a theater critic with a maniacal, murderous brother and two aunts who like to poison elderly guests. The brother's henchman tries to warn Mortimer that his brother wants to kill him, but Mortimer ignores him. The henchman wails, "Tell me, don't those plays you see all the time teach you anything? At least people in plays act like they've got sense!" Mortimer, laughing at the notion that people act intelligently in plays, proceeds to describe a really bad play with a character who "knows he's in a house with murderers — he ought to know he's in danger. He's even been warned to get out of the house, and does he go? No, he stays there." He describes how the character sits down with his back to the murderer as the killer cuts down the curtain cord he's going to use to tie him up with. This gives the evil brother lurking in the background the idea to cut down the curtain cords and use them to tie him up with it. Just when Mortimer has reached the climax of his tirade against unimaginative playwrights who make a supposedly intelligent guy act oblivious and just keep sitting where he is, waiting to be Bound and Gagged, his brother drops the curtain cord over his shoulders, and the henchman gags him with a handkerchief, commenting, "You were right about that fellow — he wasn't very bright."
First Stormtrooper: You want to bet we get killed in the next ten seconds?
Second Stormtrooper: That's a sucker bet.
First Stormtrooper: We'd probably have a chance if we weren't standing with our backs to the desert.
Metroid Prime 3, in the Metroid Xenostorage. Oh look, Metroids! I was wondering when I'd see them. Well, I'll just shoot them with Ice Missiles and be on my way. Ice attacks have always worked in the past, what could possibly go wroJESUS H. CHRIST THEY PHASE RIGHT THROUGH THE MISSILES. THEY'RE EATING MY FACE!! THEY'RE EATING MY FACE!!
From the original Prime: you're locked in a room, with a single Metroid in a stasis tank, you scan the Metroid and it breaks out. Genre Savvy players will assume you need the ice beam to kill it. The problem is at this point you will not have the ice beam. Cue screams of fear.
In Metal Saga, the player can once again be subjected to this. At one point, you get several messages warning you that the West is too dangerous and you'll die if you go there. A genre-savvy RPG player will take this to mean that should be their next destination. Turns out the advice is actually perfectly accurate, and if you do much more there than take the train over and pick up your choice of Soldier, you will be wiped out.
The insanely difficult game Syobon Action (also known as Cat Mario) works around this concept and the game it emulates: Super Mario Bros, and is does it with sadistic glee. Here, the coins are absolutely worthless, some coin blocks will kill you, the usual Mario powerups (Mushroom, Fire Flower, Starman) equal death in this world, the Warp Pipes (which in SMB were good news) will toss you to the air, and even ending a level the wrong way will destroy you.
The sequel is gentler when it comes to coins—collect 50 (compare SMB's 100) and you get an extra life. You need it. You begin off with 99 lives and... well... they're nowhere near enough, because the difficulty definitely compensates for the 99 lives. To put it simply, remember how the last game was just mean and cruel? This one is downright casting Crucio on you.
This is also the Establishing Series Moment in the arch-sadistically difficult I Wanna Be the Guy game (and its fangames). No matter which way you take, be it the one with the spike walls or the one with the delicious fruits, you are going to die AT LEAST once due to your hubris when you think you've got the game and its difficulty figured out. And this is just one of the many moments when the game will screw you and your Genre Savvy-ness over.
In Mass Effect, the Quarians create a race of machine slaves called the Geth who they accidentally let achieve artificial intelligence. Having seen plenty of movies about this sort of thing, they decide to shut down the geth before the inevitable occurs. However, they vastly underestimate the rate at which the geth have developed. The quarians then resorted to simply shutting off the geth the good old fashioned way (with bullets) and the geth responded by producing armies of themselves and slaughtering 99.9% of the quarian population, eventually butchering the quarian colonies and driving them from their home world. Then the player finds out that the geth didn't have any real beef with the quarians and were just confusedly defending themselves. 300 years later.
Not just themselves. A good number of quarians refused to let their mechanical servants/friends be destroyed. Many sympathizers were killed alongside the geth they were trying to protect. One of the reasons the geth fought back was to protect those who would protect them. Didn't save them from getting butchered like the rest, though. On the other hand, the fact that tens of billions of civilians just sort of disappeared as the geth took over may imply that the geth are seriously white-washing their role in the whole thing.
In Alan Wake, Nightingale becomes Genre Savvy due to his reading the manuscript pages. While gloating to a jailed Wake and Barry, he remembers that this very scene occurred in the manuscript and ended with him getting grabbed by the Dark Presence. He becomes terrified and starts looking for an exit, but... well, you know.
A Touhou example: as a Bullet HellShoot 'em Up, Touhou players know that getting trapped in a box of bullets is a bad idea. Anything that limits movements is dangerous enough in a game where everything (and there's a lotof everything) kills youin one shot, let alone a box which is obviously going to collapse on the character, killing them. So, when Yuuka fires off box around the player which slowly shrinks, the first time anyone fights her, they'll jump out of the box as soon as possible... to be met by an undodgeable wall of One-Hit Kill bullets and lasers that hits everywhere except inside the box, which stops shrinking just before it would have killed. Have fun being "a mist of atoms."
In the backstory of Left 4 Dead, Zoey's father gets bitten, and they've seen enough movies to not want him to become a Zombie Infectee. So, he has Zoey Mercy Kill him. Turns out afterward that he was immune to the virus. Oops.
In the Sluggy Freelance slasher pastiche "KITTEN," two Red Shirts, Randy and Cindy (a black guy and a slut, respectively), are in a car together, casually discussing how they're likely to die. Randy even mentions that he'll probably go out with some lame pun. Sure enough, Randy gets decapitated in that very comic (after being told to "quit while you're ahead"). And Cindy dies in the next strip by being cut in half, while one of the other characters comments "I always wanted to see Cindy topless."
In an episode of Alvin and the Chipmunks, in an episode parody of Indiana Jones, the villain forces Alvin (Indiana) to choose one of three mystic orbs on a pedestal. One of them is real, the other two are booby trapped. One of them has already been picked, leaving two. When Alvin reaches for the middle one, the villain immediately reasons that this is some sort of trick, and grabs the left one instead. It was the wrong choice.
"You really should learn to trust people!"
Henchman #24 in the Season 3 finale of The Venture Bros.. Despite being genre savvy (as was his close friend, #21), buckling in a non-moving vehicle turned out to be his undoing.
In typical Venture fashion, it's lampshaded hysterically.
Inverted somewhat in Teen Titans. In an episode where the Titans find themselves stalked by monsters, Beast Boy uses his knowledge of horror movies to correctly predict that, as the Genre SavvyPlucky Comic Relief, he'll be the first victim, and isn't exactly surprised when he's proven right.
Played straight a few minutes later, where Robin is taken when he's about to explain why everything's happening.
In King of the Hill, the Hills visit a Renaissance fair, where the "king" has fairgoers throw tomatoes at Peggy. She tells them that potatoes would be more historically accurate, at which point the fairgoers readily switch their ammo. Not a death per se, but Peggy didn't exactly do herself any favors.
She's wrong about the potatoes anyway. Neither they, nor tomatoes, were known of in Europe during the Medieval period.
Subverted during the serial killer challenge on Total Drama Island—Gwen continually warns the others about typical horror movie clichés, but one by one they don't listen and, of course, get caught by Chef. Duncan, the second most Genre Savvy character, manages to defeat Chef when he purposefully goes to fight him, while Gwen winds up fighting a real serial killer who shows up, winning the challenge.