Mad Scientist: The "Designated Villain" example is one trying to cure cancer, specifically in order to render cancer charities and certain doctors out of a job, and stop cancer patient survival biographies/memoirs/whathaveyou from being written.
"...Iím trying my hand at something new. For the most part, this blog has focused on the bad writing of fiction Ė implausible plot twists, awkward turns of phrase, unconvincing characters and so on. Meanwhile, non-fiction has got off all too lightly. Itís time to do something about that."