In Thanatos Scowled Danny tells Nico that Clockwork only intervenes if there's a major issue with the timeline, and Nico wonders if Clockwork has intervened in events like WWII, and the current world is simply the best that humanity has done so far. In Loki (2021), which was released not long after said chapter was published, we learn that the TVA views the canon MCU timeline as the "Sacred Timeline", implying that it's the best possible reality, and zealously try to keep others from interfering with it.
Certain stories discussed and brought up the existence of the multiverse beyond their current universe, with Doctor Doom pulling in different universes into this version of the MCU. Come Loki and What If…? (2021), the multiverse is officially introduced into the MCU.
Unexpected Character: Rook Blonko makes an appearance as Max's partner/protege in the epilogue of Changing of the Guard. Since the Ben 10 side of the series largely derived from the first three series (a few elements of the reboot notwithstanding), his appearance came off as a shock to many readers.