- Ear Worm: Sister, Sister!
- Retroactive Recognition: A pre-stardom Brittany Murphy guested in several first season episodes.
- Similarly, Gabrielle Union was a 5th-season friend of the girls before she went on to movies like Bring It On and Bad Boys II.
- A young Orlando Brown (aka Eddie from That's So Raven) guest-starred once.
- Taraji P. Henson, now known for Person of Interest and Empire, was a 5th-season classmate.
- Regarding the dubs, in the Mexican Spanish one it's easy to recognize Alma Wilehelme as the VA for both twins, Nancy McKenzie as Tia's adoptive mother Lisa and Gerardo Reyero as Tamera's adoptive father Ray.
YMMV / Sister, Sister