- Executive Meddling: The game was originally due out April 23 on PC, but demands from Microsoft that the Xbox 360 version be given top priority in terms of release pushed the PC version to the 26th.
- Fandom Nod: There were a few that mistook Sal's voice actor for Patrick Warburton due to just how much they sounded alike. This game has Sam noting Brock's voice sounds somewhat like Sal's.
- He Also Did:
- Jared Emerson-Johnson, the composer, is also the voice actor for the Marquis De Singe in Tales of Monkey Island, and the composer for the Telltale-era Sam & Max: Freelance Police games as well as Telltale's The Walking Dead.
- Danny Webber, the composer for Workaholics, does Ash Williams. He also played Steve in Birdemic Shock And Terror. Really.
- Keep Circulating the Tapes: Was pulled from sale on September 2018 after licenses to the respective properties have expired, shortly before Telltale itself disbanded. Those who purchased the game beforehand can still access it.
- The Other Darrin:
- Lampshaded by Claptrap who asks Sam and Max what happened to their voices since Hit the Road and Sam & Max: Freelance Police (directly referencing the former's tone). Sam claims he started seeing a speech coach and Max just never stopped using a Jason Alexander impression and his voice slowly changed as a result.
- Ash is not Bruce Campbell here for unknown reasons, and voiced by Danny Webber of Birdemic fame.
- William Kasten, voice of Max, is replaced by David Boat, also known as the shopkeeper in the Video Game Remake of Monkey Island 2: LeChuck's Revenge and Lexaeus in the Kingdom Hearts series.
- What Could Have Been:
- At one point in development, there was a Walking Dead themed Inventory that would be available for purchase. It'd be similar to the Everett family drugstore, boarded up from the inside, but the area would be filled with zombies. Unfortunately, no Walking Dead main characters or bounty items were planned; only the Walking Dead inventory for the sake of referencing Telltale's more popular series at the time. Judging from cut dialogue, the "first eliminated" punishment would've thrown the unfortunate loser to the walkers (of course, all of our competitors are prepared for such a thing...well, except Claptrap, but who cares about him?). This got cut for time, and the only real evidence that remains of it are the rarely-played-but-still-existent jazz remixes of Clementine's Theme and the theme inside the school from Episode 4. These tracks are found in the game's files, as well as dialogue and sound effects that most likely would've been used for this layout.
- Speaking of The Walking Dead, Lee and Larry were considered as players for the game at one point, but were cut because characters from a very sad game especially considering both die would seem weird to fans who watch them partake in an upbeat poker game.
- The Medic of Team Fortress 2 character was considered, but GLaDOS was chosen because another Team Fortress 2 character would be repetitive—plus, she has much more personality than the original dealer/host, Reginald Van Winslow.
- Marty and Doc Brown were also considered at one point, but since there's a lot more mature characters in the game (Brock, Claptrap), the cursing would sort of affect the family-friendly value of Back To The Future.
- Reportedly, Bruce Campbell was asked why he didn't voice Ash's lines in the game. His reply was simply that he didn't even know about the game. For whatever reason, Telltale either didn't ask, or were unable to get in touch with him.
- A cut conversation implies that Girl Stinky was originally supposed to be the bartender instead of Moxxi, perhaps to round out Skun-ka'pe as the chauffeur.
- Voice lines:
Trivia / Poker Night 2