- Actor-Inspired Element: According to Audrey Hepburn, the scene where Regina spills ice cream on Alex's suit is based on a real-life accident where Hepburn spilled red wine over Cary Grant's suit at a dinner party.
- Creator Couple: During the dance game in the nightclub, Audrey Hepburn's husband, Mel Ferrer, can be seen briefly in the background, smoking a cigarette.
- Follow the Leader: Universal tried to recreate the success of Charade with Mirage (1965), which is Darker and Edgier but shares many of this film's elements: It's a Thriller with a twisty plot, Witty Banter, a snappy One-Word Title, and a May–December Romance between the two leads. The films also have screenwriter Peter Stone and actors Walter Matthau and George Kennedy in common. In 1966, Universal made two more similar films, Arabesque, also scripted by Stone and directed by Stanley Donen who also directed Charadenote and Blindfold (whose supporting cast included Ned Glass from Charade).
- Wag the Director: A positive example. Cary Grant was uncomfortable about the age gap between himself and Audrey Hepburn (he was 59 and she was 33). To satisfy his concerns, the filmmakers agreed to add several lines of dialogue in which he comments on his age and Regina — Hepburn's character — is portrayed as the pursuer.
- What Could Have Been: At one point, the film was going to star Warren Beatty and Natalie Wood fresh off their hit Splendor in the Grass.
- Working Title: The Unsuspecting Wife.
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