Adam West appears in one episode voicing himself as an unhinged man disconnected from reality. Clearly Seth MacFarlane liked the idea because on Family Guy, Adam West voices himself as an unhinged man disconnected from reality. Butch Hartman did, too; Adam West on The Fairly OddParents! clearly isn't quite right in the head, and Jeff Bennett, the voice of Johnny Bravo, would eventually replace Adam West as the voice of Catman in the last two seasons of the latter show.
In one episode, Johnny's girlfriend while watching a movie on a date comments that she is a fan of "Swedish Karate movies". As ridiculous as that sounded, years later a movie featuring several martial arts fights, Kung Fury, was made by Swedish director David Sandberg was made and released in 2015.
In "Wilderness Protection Program", the elk boss' puzzle is a koala bear, which resembles another character on another kids' show animated by Saerom.
The episode "The Great Bunny Book Ban" became hilarious when many school districts in Florida(as a result of governor Desantis over-the-top and overly broad laws) banned several childrens books("Arthur" books notably being among the examples) for incredibly ridiculous ridiculous reasons.