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Stan: Yeah! You know, we believe in equality for everybody, and tolerance, and all that gay stuff, but dude, fuck you.
Totally Spies!!: Frequently used by the characters against revenge-seeking antagonists, usually in the form of "You're only doing this for revenge!" (often complete with deconstructions of any supposedly-good goals the villain has).
This happens with Megatron and Optimus in the last episode of Beast Wars. See the page quote.
In "Code of Hero", Megatron was speechifying about how Dinobot had no hope of defeating him (which, given that Dinobot just burned up all his reserves and taking massive quantities of damage fighting through Megatron's minions while Megatron had not yet done a thing, not to mention he's got massive upgrades which makes him even more resistant to damage, makes a pretty good point). Megatron asked "What can you possibly do?" Dinobot's response? "Improvise". As he takes his stick, creates a makeshift hammer, and smacks Megatron to the ground.
In the second season finale of X-Men, Mr. Sinister gets plenty of self-righteous speechifying about the future out of the way while he has his audience chained to a wall. Eventually, the tables turn, punctuated by an optic blast from Cyclops. This doesn't stop him from weakly defying Scott's repeated request to leave his friends alone.
Sinister: I can't... I won't... the world needs— (gets cut off by another blast) Cyclops: What was that? I don't think I heard you right!
He gets it again about two minutes later. Trying to pull himself together, Sinister grumbles that "the future" (his future) can't be destroyed so easily. Jean Grey responds with a calm "Yes, it can" and a well-placed shot of telekinesis. This is appropriate, since he was trying to effectively breed a new race from the two of them.
Alternate Flash:Slacker! Child! Clown! We have no place here among the world's greatest heroes! Flash: Says you! I've got a seat at the big conference table. I'm gonna paint my logo on it! (Flash punches through Evil Flash's chest and vibrates his arm at Super Speed; explosion ensues)
The Flash does it again later in the same episode when Braniac/Lex Luthor taunts him on the fact that he was all that was left between total destruction. Flash then begins to pound Luthor over, and over, AND OVER, stripping Braniac's tech from Luthor's body with each blow. Made all the more awesome when you realize that Flash was doing this by running around the Earth at 25,000 miles PER SECOND as he hit Luthor time after time.
Lampshaded earlier in the episode Wild Cards.
The Joker: Even you can't disarm one of my bombs in time! Flash: Shut Up! The Joker: What kind of retort is that!? You're not even trying!\
Which is then subverted when he grabs Terry and starts to choke him, telling him to laugh it up now.
Terry: Ha...ha. (pulls out Joker's killer buzzer and proceed to shock him)
Another small one happens in the series when Kobra leader Xander tells Max of his plot to turn all his men into dinosaurs and drop a bomb that will incinerate the world so they have extra heat to live on. She responds accordingly:
Max: I think I finally get it now. Xander:(he smiles) Max: You're crazy! All of you! Certifiable in need of medication!
Jeepers: You want to see something strange and mystical?
Freakazoid:NOOOOOOO!!!!! GET OUTTA HERE WITH THAT WATCH!!! LAY OFF THE POOR BEAVERS, WILL YA?!? SHEEEESH!!! YOU'RE A CREEP! GO AWAY! WE WERE ALL HAVING A GOOD TIME UNTIL YOU SHOWED UP, JEEPERS!!! UUUUUUUUGH! GO HAVE A COFFEE, WITH CREAM OR SOMETHING! BECAUSE I'LL TELL YOU SOMETHING: THIS IS A HAPPY PLACE!!!!!!
Samurai Jack was likewise shut up by a bounty-hunter who tells him "I got bills to pay, and I already addressed the envelopes." Jack begins to respond with a clever phrase, saying "I hope you haven't you haven't yet stamped the parcels which you—" but is cut off as the bounty-hunter punches him out, saying "consider 'em stamped."
Kim Possible's Crowning Moment of Awesome from So The Drama, when she interrupted Drakken's speech about how he cracked Kim's weakness; her own insecurities, especially regarding dating. Not quite a pure example, since he didn't know she was listening in, but she definitely had the "Shut up!" part down!
"You're right, Drakken. Boys, dating, that's hard. But this is easy. (She punches Drakken. Hard.)
Another very ironic example: In one episode, a bump on the head made Bubbles think she was Mojo. Apparently, Mojo found listening to her imitation of his endless rants just as annoying the Girls found it when he did it, so he just yelled "OH, SHUT UP!" and clocked her with a steel beam. (Unfortunately for him, he went right back to doing the exact same thing, and didn't notice that he had knocked the sense back into her, and well, you can probably guess how it ended.)
A particularly epic example comes from Toy Story 3, where Woody exposes Lotso's lies to Big Baby.
Lotso: "Then she threw us out!"
Woody: "No, she lost you."
Lotso: "She replaced us!"
Woody: "She replaced YOU! And if you couldn't have her, no one could! You lied to Big Baby and you've been lying ever since!"
Yosemite Sam: "Any one of you lily-livered, bow-legged varmints care to slap leather with me? In case any of ya get any idears, ya better know yer dealin with. I'm the hootinest, tootinest, shootinest, bobtail wildcat in the West! [fires guns, raising Sam up] I'm the fastest gun north, south, east annnnnnnd west of the Pecos!....I'm the...."
Darkseid: People of Earth, I am Darkseid, lord of Apokolips. Here is your savior, cowed and broken. I have crushed him as easily as I have crushed all who dared to oppose me throughout the cosmos. I am power unlike any you have ever known: absolute, infinite, and unrelenting. You have no choice but to prepare for a long dark future as my subjects and my slaves. Dan Turpin: ...In a pig's eye!
At the end of the three-part pilot "The Last Son of Krypton", Superman confronts Lex Luthor. Luthor gives a speech about how he owns Metropolis and that Superman should be working for him. Lex loses his cool when Superman responds with a simple "I'll be watching you, Luthor."
Princess Celestia actually fires off twoShut Up Hannibals in Part 1's Canterlot Tower scene. The first time, Discord tries to get a rise out of her with a Break Them by Talking; she shoots him down. The second time, Discord's in the middle of another one directed at the Mane Six; she butts in to order him to quit screwing around and answer her question. He tosses her a riddle and vacates. The blink-and-you-miss-it look on her face seconds later suggests she was indeed winding up a thirdShut Up, Hannibal! In case you needed her to validate her previous claim to being a Retired Badass.
Happens in the second episode of the first Teenage Mutant Ninja Turtles series, when The Shredder says the turtles should join him because it was his mutagen that transformed them from their pet forms, hoping they'll ignore the little detail that he also turned Hamato Yoshi into Splinter, was actually trying to kill Yoshi and currently has Splinter tied and suspended from the ceiling. Naturally, Raphael has the perfect response: "Does the phrase 'go suck a lemon' hold any meaning for you?"
Less eloquent but as effective, Hulk Vs. Thor shows Loki interrupted in mid-rant by Thor's hand around his throat. A "Shut Up, Hannibal" via sign language?
In A Bug's Life, Flick shuts down Hopper's bullying. Made more impressive by the fact that Hopper has just had Flick beaten within an inch of his life. And even more impressive that it's an Eureka Moment for Flick near the end.
Hopper: Let this be a lesson to all you ants. Ideas are very dangerous things. You are mindless, soil-shoving losers! Put on this earth to serve us!
Flik: You're wrong, Hopper. Ants are not meant to serve grasshoppers. I've seen these ants do great things. And year after year, they somehow manage to pick food for themselves and you! So-so who is the weaker species? Ants don't serve grasshoppers! It's you who need us! We're a lot stronger than you say we are. And you know it, don't you?
Kaijudo Rise Of The Duel Masters has an especially epic one in the season 2 finale, as well as a rare practical use of the Power of Friendship. As Ray and the Choten are dueling, the Choten uses a spell to control two creatures at the same time, all while gloating about how naive Ray was to think befriending creatures could be a good substitute to controlling them. Ray answers by summoning five additional creatures and sending them all to attack him.
Choten: You can't possibly control that many creatures at the same time!