In The Order of the Stick#595, Daimyo Kubota's discussion of how he plans to escape responsibility for yet another attack on the surviving Azurites is interrupted by Vaarsuvius: "Disintegrate. Gust of Wind. Now can we PLEASE resume saving the world?"
Made somewhat disturbing though by the next comic, which reveals V didn't even know who Kubota was. V simply disintegrated him because Elan had him tied up, so V assumed (correctly) that he was a villain.
And Disjunction is first real glimpse of how powerful V became under the Soul Splice. It only has a 1% chance per caster level of breaking an Anti-Magic Field, and the Class and Level Geekery thread estimates that V by themself is about level 14-15 based on the spells they've cast alone. But with 3 Epic-level souls spliced on (one of which was very likely higher level than Xykon), V's effective caster level was somewhere close to 100, which in D&D terms is insane.
Nale: I gave you a chance to join me. But you'd rather stay with these fools? Well, I can't very well allow you to continue breathing after an insult like that, now, can I? Because no one denies me, Elan. Not father, not you, no one.
Elan: Deny. Deny. Deny! ♪Deny the psychopathic egomaniac!♪
Later, he admits that she actually did get to him, as the entire reason he'd been picked to question her in the first place was because he had the best hand for interrogating without strife, and he'd let her provoke him into being a sarcastic ass instead of handling the situation calmly. Unfortunately, all this did was enrage her to the point of attacking him with the heel of her shoe instead of giving them what they needed, and he got bailed out by Shanna for screwing up the session.
And of course, leave us not forget Rikk's earlier and more spot-on example of this trope, during his climactic confrontation with Keith Feddyg before the Time Skip.
Rikk is good at these. During the Order arc at the end of book 6, he and Marc confronted Hus, one of the Order's mages, who was attempting to take over Egypt in the wake of spell that literally destroyed the concept of written communication. After Hus gave Rikk a "Reason You Suck" Speech, Rikk and Marc effectively shut him up:
Rikk: First off, I got sucker-punched by Captain America. That's like giving Michael Phelps a headstart. Secondly, I've spent the last five years with two remarkable women. One of them's one of the toughest, cleverest fighters I've ever seen anywhere. The other is Rumiko Tanaka Oberf. We work hard, but we do make time for each other. And when we're not vegging or sharing a bed...we like to spar. Marc and I aren't here to impress you, Hus. We're here to bring you to justice.
Marc: Bully needs a beatdown! (Beat) Yours was way more wootworthy.
Rikk: No, you gave a good closing statement.
Subverted in 8-Bit Theater. Fighterthought he was giving one of these to a giant who was talking to his party members after squishing Black Mage. In actuality the giant was giving the Light Warriors a Glurge-filled speech about the Disproportionate Reward he was about to give. Red Mage and Thief were very upset at losing the opportunity to commandeer an army of loyal giants.
Also played straight in the confrontation against Sarda, because Black Mage "never knew it was possible to care less about time travel."
Lightbringer: After Darkbringer defeated the main protagonist, before killing him, he showed him beaten to people on the street, and started a Break Them by Talking about how the only true way of good is by embracing darkness and despair and hope Lightbringer gave them is a lie. People responded by throwing junk at him, while screaming examples of how Lightbringer make their city a better place.
Karcharoth of Cry Havoc pulls one on Faustus by way of a burst of machine gun fire.
Happens in Goblins when Thaco successfully defeats Goblinslayer. As the man lies slowly bleeding to death, his ear sliced off, he gloats. He thinks that, if nothing else, his legend will survive in the stories of the goblins as the great nemesis of Thaco, only to be told mid-rant...
Thaco also manages to turn Dellyn's previous Break Them by Talking against him. when Dellyn learned that Thaco had taken levels as an adventurer, he described it as 'the most perverted thing I've ever heard of'; Thaco responds by describing Dellyn as 'some random human I fought early in my adventuring career... a random encounter.'
Minmax delivers a spectacular one to his Psion alternate counterpart, as the latter proclaims that Evil Only Has to Win Once and that he will win eventually...
In Clockworks, "You have no words for me? No threats for the man who killed your father? Nothing to say to the man who abducted your lady friend's parents? No witty banter to exchange — " Enough! with a kick
In the end of the Bad Behaviour series of Sinfest, Criminy shouted ENOUGH to Seymour while he was in the midst of a hateful sermon, essentially bragging about causing Fuschia to have a Despair Event Horizon. This starts a three week consecutive story arc (one of the longest in the strip's history) which becomes a giant Crowning Moment of Awesome for Criminy.
Kaleb: Bastard! You think you're really changing anything? Solus has more power and influence than you could ever dream of. You can't stop him — and if you kill me, another will take my place. Agrippa:(slashes Kaleb's throat with his combat knife) Then their fate will be the same as yours.
In The Adventures of Dr. McNinja, King Radical has spent the concluding arc weakening and ruining Dr. McNinja: Cleverly positioning himself in such a manner to gain the Presidency, detaining McNinja, making him fight past enemies, killing his clone just as he made peace with him, making his sidekick a vampire, having his parents sell him out. Even killing the Birdosaurus to assure he will never feel the satisfaction of killing it. He then goes on a lengthy "Reason You Suck" Speech that points out how ridiculous and self-centered McNinja has been in the entire story, and that his intentions have long been noble albeit criminal. Dr. McNinja's response? Grab Dracula, wield him like a baseball bat, and cause him to bite King Radical, making him into a vampire, followed by this:
Dr. McNinja: Yeah, "Champion of the Future." King "I Am A Force" or whatever. Now you're a vampire.
throws Pope Francis
Dr. McNinja: Just like all the others I killed in grad school.