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- In Fullmetal Alchemist, there are seven characters named after the Seven Deadly Sins of Pride, Wrath, Sloth, Lust, Envy, Greed, and Gluttony. They are the embodiments of Father's sins.
- In Karakuridouji Ultimo, there are fifty Douji representing positive traits. Ultimo and the Six Perfects of Buddhism are the strongest of them, fighting against the Douji based on negative traits (including the Seven Deadly Sins).
- The shonen manga series Katekyo Hitman Reborn! has the seven sins represented by the seven top members of an elite assassination squad, the Varia. The seven protagonists set to battle against them in a fight for the right to inherit a powerful mafia family embody the Seven Heavenly Virtues (but not as obviously as the antagonists). The Varia take their names directly from the Seven Deadly Sins:
- Greed: Mammon (obsessed with money)
- Envy: Leviathan (wishes to be the only one to please his boss; is envious of Tsuna and his group from taking his "rightful" position as Thunder Guardian)
- Gluttony/Gula: Gola Mosca (consumes the Dying Will Flames of Vongola IX for power; bonus points for "mosca" meaning "fly", as Beelzebub is also known as "Lord of the Flies")
- Lust/Luxuria: Lussuria (admires the bodies of other men)
- Pride/Superbia: Superbia Squalo (a loudmouth very proud of his rank as #1 swordsman in the world)
- Sloth/Acedia: Belphegor (a natural-born killer who is lazy and doesn't take his job very seriously)
- Wrath: Xanxus + Flame of Wrath (a generally unpleasant person who calls those he considers beneath him scum. He possesses the Flames of Wrath, originally owned by Vongola II, the most powerful Dying Will Flames in existence).
- In Panty & Stocking with Garterbelt, the fallen angels Panty and Stocking represent the sins of Lust and Gluttony, respectively.
- In The DCU, the Seven Deadly Sins, or rather their Anthropomorphic Personifications, are imprisoned inside the Rock of Eternity by the wizard Shazam (Same guy who empowered Captain Marvel of I Am Not Shazam fame), though their influence is still passively felt throughout creation.
- Until recently "Injustice" took the place of "Lust", presumably due to the Comic Book Age Ghetto.
- Until the late '80s, they were often called "The Seven Deadly Enemies of Man" in order to avoid overt religious references (another age ghetto no-no.)
- The 2009 Batman annuals feature a group of seven villains who call themselves La Saligia (an acronym of the Latin names of the sins), and seek to awaken the Eighth Sin of faith. Any connection to the Seven Deadly Enemies of Man is unknown. This group became villains of Azrael, who appears as the protagonist in each of their stories.
- A French graphic novel, Seven Monks, told the story of seven Irish monks, each embodying one of the deadly sins, receiving punishment for their sins by being sent to convert a village of pagan vikings. Incredibly, by applying their sinful behaviors in creative ways (the avaricious monk uses the lure of profitable trading with Byzantium, the envious monk convinces the chieftain's second-in-command to take over upon his death, the lustful monk seduces every woman in the village, and so on) and with some incredible coincidences, they succeed in their mission without changing their ways in the slightest.
- Yet another example from DC: in Titans Together, six sons of Trigon sired from human mothers at around the same time as Raven have emotion-manipulating powers based on the sins. They try to awaken Raven's evil side and get her to join up. In an open defiance of convention, the one female in the group isn't lust; Raven instead filled the "pride" slot. Stuck on evil mode, Raven later tried to transfer her brother's abilities to the Titans.
- Donna Troy got stuck with Lust, rather than the more obvious choice of Starfire. This was a reference to the fact that Donna has gone through multiple relationships and been the object of desire of many men, even moreso than Starfire.
- Cyborg was Wrath, which seemed to be a Stealth Pun on the Angry Black Man trope.
- Red Arrow got Gluttony, and while he became fat as a result, this was a possible reference to his former heroin addiction, thrill seeking, and womanizing tendencies, fitting in with Gluttony's nature of excessive consumption.
- The variant covers of the first issue of DV 8 depicted the team as the Seven Deadly Sins. Threshold, a Psychopathic Manchild whose boss Ivana controlled him with sex, was Lust. Bliss, a spoiled rich girl, was Greed. Powerhaus, who feeds off ambient emotions to get stronger, was Gluttony. Evo, a monster man with an attitude problem, was Wrath. Frostbite, a pessimist who doesn't care about anything, was Sloth. Copycat, the girl with multiple personalities whose only friend is herself, was Pride, and Sublime, a supermodel type who longed for the attention of Genął member Grunge, was Envy.
- See them all here.
- In the Green Lantern lore, colors represent emotional qualities/states: Red and Orange represent the vices of Wrath, and Avarice respectively. Yellow represents Fear. Green for willpower, Blue for hope, Indigo for Compassion and Violet for Love.
- The Hulk himself is wrath, of course, but there are more subtle examples in his various personalities- Banner classically dealing with issues of self-loathing and fatalism, for instance. Many of his classic foes have also been examples of the trope; for instance the Abomination is typically portrayed as an embodyment of Hubris.
- This deviant-artist portrayed seven of the original girls from Total Drama Island as the Seven Deadly Sins, with quite logical reasoning:
- There exists a really good Harry Potter fanfiction that features several villains as the sins:
- The Seven Disney Sins:
- This One Piece fic has identified the original seven Straw Hats with a sin.
- Clash of the Elements: According to Cackletta in Part 2, The Dark King's control over darkness stemmed from a balance between all seven of them, and that his death was caused because he succumbed to a few of them simultaneously. As of the most recent chapter though, Alex's clone has revealed that he holds copies of the Genesis Samurai's spirits that each represent a different sin:
- Se7en centered around a Serial Killer committing his murders based on these sins. The victims therefore become allegorically associated with the respective sins they were murdered for.
- Repo! The Genetic Opera features the Largo family: Rotti Largo, the powerful businessman and his three children: Amber Sweet the surgery addicted, drug-addict wannabe singer, Luigi the raging, mass murdering sociopath and Pavi the effeminate, face-stealing Casanova. While all four are vain and greedy, Rotti in particular represents Envy and Greed, Amber is Sloth and Gluttony, while Luigi is Wrath (as the producer Darren Lynn Bousman has stated) and Pavi is Pride and Lust.
- In the 1967 Deal with the Devil film Bedazzled (1967), the protagonist Stanley Moon meets incarnations of the seven deadly sins. Anger is a hostile bouncer who wears a T-shirt that says "Make War, Not Love", Sloth is always sleeping, Gluttony is a Fat Girl, Avarice complains about how much money's being spent on a date, Envy accuses the other sins of getting special treatment, Vanity has an upward-bending arm with an inward-facing mirror attached to it protruding from his midsection, and Lust is, well, Raquel Welch.
- Older Than Print: In Dante's The Divine Comedy , the Mount of Purgatory (described in the Purgatorio, the second part of the Comedy, where sinners who repented before death are purged of their sins) is arranged around the Seven Deadly Sins, from most-serious to least-serious (in Dante's evaluation):
- The Proud, on the First (lowest) Terrace, walk carrying heavy stones on their backs, so that they cannot stand straight or look down on anyone else.
- The Envious, on the Second Terrace of Purgatory have their eyes sewn shut. In life they envied what they saw; to purge their sin, they see nothing.
- The Wrathful are on the Third Terrace, where they walk constantly, blinded by acrid smoke, just as they were blinded by wrath in life.
- The Slothful are on the Fourth Terrace, being purged of their sin by constant running.
- The Avaricious are on the Fifth Terrace, lying face down on the ground. This is generally considered a breaking point: the previous four sins were all about perverted or deficient love and are considered more severe, while this sin and the two that follow are all about excessive love for material things and are more excusable (although Dante thought it was a stupid sin to be guilty of).
- The Gluttonous are on the Sixth Terrace and their penance is to pass through groves of fruit and by waterfalls of pure water without eating or drinking.
- The Lustful are on the Seventh and last Terrace of the Mount of Purgatory, where their sin is purged from them in a wall of fire. They run through this in two directions: those who lusted after the opposite sex in one direction, those who lusted after the same sex in the other. (Yes. What?)
- Scrooge in A Christmas Carol is an obvious personification of greed.
- In Keys to the Kingdom, the seven Trustees, Mister Monday, Grim Tuesday, Drowned Wednesday, Sir Thursday, Lady Friday, Superior Saturday, and Lord Sunday, are representations of Sloth, Greed, Gluttony, Wrath, Lust, Envy, and Pride respectively (along with another obvious theme).
- In the video for Poets of the Fall's Obsession Song "Carnival of Rust," Mr. Greed is the Carnival's brightly colored, nattily-dressed, creepily grinning barker, who happily takes the money of the gas-masked woman and gives her a prize for winning his game. He's also a dead-ringer for "Rust's" singer, the bedraggled, monochrome Love Hungry Sad Clown Zoltar, implying that the latter has some issues he needs to work through about his idea of love.
- In Overlord, the fallen heroes who serve as the bosses are each themed for a sin, having fallen into decadence after their grand victory. For the first five bosses there is also a moral choice themed around the sin.
- Melvin Underbelly (Gluttony): A small halfling whose appetite ran out of control when fame went to his head. His subjects raid human villages to gather the massive amounts of food needed to feed the now morbidly-obese Melvin. Hidden in his lair is a massive store of food. You can return it to the starving villagers or use it to feed your minions.
- Oberon Greenhaze (Sloth): An elf who fell into an endless sleep, depriving his people of the hero they needed when dwarfs razed the kingdom. Then, just to top things off, Oberon's nightmares started manifesting while he turned into a giant tree-weed slowly consuming his forest home. Deep in the forest is the last untainted grove, filled with enemies and loot. You can fight each enemy to retrieve the treasure or take the easy way and burn it down.
- Sir William the Black (Lust): Abandoned his fiancée and knightly ways to house a succubus queen, founding a cult dedicated to carnal pleasure (sheep in the brothel anyone?) and letting the succubus transform the hapless citizens of his city into a zombie horde. Locked away in the castle is your second choice of mistress, the very sensual Velvet. You can choose to remain faithful to Rose or claim Velvet as your own.
- Goldo Golderson (Greed): A gold-hungry dwarf who razed the elven kingdom to steal their treasures and used the survivors of the elven race to mine gold in his own kingdom. Deep in Goldo's collapsing castle are two treasures: A mountain of gold and the last elven women. You can save the elves or the gold before time runs out.
- Jewel, the Thieving Hero (Envy): Kleptomanic thief, constantly steals things other people want. It doesn't matter what it is or if she can use it; if somebody wants it, it has value and she'll take it. On her defeat you recover the stolen statue. You can return it to the elves or claim it as part of your fortunes.
- Kahn the Warrior (Wrath): A massive warrior easily overwhelmed with rage for even the most minor issues. Only Jewel could calm him, and after you kill her, well... Meanwhile, your "loyal" subjects in Spree betray you to save their own hides from Kahn's fury, you can decide if you want to let this go or give in to your anger towards them and butcher them all.
- The Wizard (Pride): A man who dedicated his life to defeating the previous Overlord only to be possessed by his foe's spirit. He was responsible for the downfall of the other heroes and attempts to usurp (well, reclaim) the player's position as overlord. Sure in his ability to reclaim his position, he was defeated by the very pawn he had empowered to achieve his ends. This last one seems a less obvious aesop as the others, until the final battle where he gloats how he personally corrupted each of the original heroes one by one throughout the entire fight; pride comes before the fall.
- Dead Rising 3 features seven Bonus Boss fights with seven psychopathic individuals. Each of these individuals represents one of the seven deadly sins; six of the seven (or all of them, depending on the player's actions) also receive a nasty Karmic Death.
- Albert Contielllo, a highly unethical surgeon who takes special pleasure in hacking people open and represents Greed. Contiello is obsessed with making money, and, rather than help other survivors, instead harvests their organs to sell on the black market. After Nick defeats Albert, he injects the doctor with the syringe he uses to knock out his victims, making him hallucinate and eviscerate his own body.
- Darlene Fleischermacher, an enormously obese and disgusting woman who represents Gluttony. Darlene spends her days in an all-you-can-eat buffet, stuffing her face and hoarding every scrap of food that she can. Upon her defeat, she tries to ram Nick with her mobile scooter, only to knock herself onto the ground; unable to stand, she chokes to death on her own vomit.
- Dylan Fuentes, a sex-crazed man who kidnaps survivors to force them into sexual acts and represents Lust. His hideout is a sex shop, where he tries to tempt Nick into both having his way with imprisoned survivors and engaging in some "fun" with Dylan himself. After being defeated, he collapses on the floor as a huge spurt of oil comes from his phallic-shaped "Lust Cannon".
- Jherii Gallo, a musclebound female bodybuilder who represents Pride. She takes over a local gym and spends her time posing in the mirror and preparing for a nonexistent bodybuilding competition. Nick makes the mistake of calling her a man, which leads to a battle. When Nick defeats Jherii, she tries to calm herself down by reciting a mantra, only to inadvertently crush her own skull with a set of large bodybuilding trophies.
- Kenny Dermot, a chubby nerd who desperately wants to be a hero and represents Envy. He cowers in a construction site, fearful for his safety, before Nick arrives, and he even looks up to Nick for his bravery. However, Kenny eventually decides to stage heroic stunts to build his own self-confidence, and when Nick interferes, the two battle. It is possible to save Kenny after the battle, upon which he'll perform a Heel–Face Turn; if the player chooses to let him die instead, Kenny is eaten by the zombies he claimed he could fight.
- Theodore Lagerfeld Jr., a fat slob who spends all of his time hiding in his father's mansion playing video games and represents Sloth. Theodore has a key that can unlock an armory full of helpful weapons, but is too lazy to give that key to Nick; when Nick tells him off, he sends out remote-control helicopters to kill the "intruder." When Nick finally reaches Theodore's central room, the spoiled man dies of a heart attack before Nick can even start fighting him.
- Harry "Zhi" Wong, a monk-like East Asian man who spends his days in a Zen Garden meditating and represents Wrath. Harry's apparent placidity is a front—he brutally murders anyone who disturbs his meditation and has a Hair-Trigger Temper. When Nick defeats him in battle, Harry rattles off a long list of all his misfortunes before chopping off his own head.
- Just like the Companions of the Avatar in Ultima IV embodied the Eight Virtues, the Shadowlords in Ultima V embody the opposite of the Three Principles upon which the Virtues are based (Love, Truth, Courage)—namely, Hatred, Falsehood, and Cowardice. Similarly, the Banes of Chaos in Ultima VII Part II are the physical embodiments of the the Ophidians' Anti-Forces: Wantonness, Anarchy, and Insanity.
- Each of the Palace rulers in Persona 5 represent the seven deadly sins, with the addition of Vanity, a variation of Pride. However, once the treasure of the Palace is stolen and the place collapses, they will see the wrong of their ways and often confess their crimes.
- Sins has personifications of the seven deadly sins as its main characters. Most embody their sin to some extent, but since they're the protagonists, they're treated pretty sympathetically.
- Spirit summons in Widdershins are based on emotions rather than morals, but summons keyed to the Seven Deadly Sins are noted as being especially powerful: a Hunger spirit merely chews its way through a bakery, while Gluttony turns an entire hotel into an eldritch Genius Loci. One of the villains is a spirit of Lust who escaped its summoner in a physical form and gathered a Quirky Miniboss Squad of mortals exemplifying the other sins.