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- This is the Anti-Spiral modus operandi in Tengen Toppa Gurren Lagann, arranging Manchurian Agents, Colony Drops and Hope Spots because the Power of the Spiral can't be defeated through main force. All to save the world, of course. Although this is effective on some characters, it ultimately backfires, leading Team Gurren to the Anti-Spirals' home dimension and giving them a plethora of Lagann-type mechs with which to take them down.
- Similarly to the Anti-Spirals, the Incubators from Puella Magi Madoka Magica drive teenage girls to despair by making contracts with them and encouraging them to Make a Wish that they know will backfire, leaving out important details of the MagicalGirl contract such as the required lichification, and eventually driving the girl to the Despair Event Horizon wherein they will become a Witch, which will then be killed by other magical girls for it's energy. The witches will also drive people to suicide, ensuring more despair. The point of this is to use that energy to save the universe from heat death. Also like the Anti-Spirals, it backfires: Madoka uses her wish to become a god and erase the whole witch system from existence, and when the Kyubeys try to bring it back in The Movie, Madoka defeats them again- for good this time.
- This is Knives' instruction to his minions in Trigun, in the hopes that it will make Vash give up his stewardship of humans and join the other side. In the anime, it works, and Vash breaks down, becoming almost catatonic, at least until a moment of redemption redoubles his resolve.
- In GUN×SWORD, Woo not only defeats Van in battle but also forces Van to recognize his own terror and confront the possibility of dying. It nearly works: Van is so shaken by his new fear of death that he is prepared to give up his revenge quest and run away. Fortunately, his sidekick calls him on his cowardice and challenges him to man up. The Power of Love does the rest.
- In Monster, Johan seemed to be attempting this with Doctor Tenma.
- The "Revenge Arc" of Rurouni Kenshin deals with Enishi's attempt to reduce Kenshin to a pathetic homeless wreck by destroying everything Kenshin holds dear, in revenge for Kenshin's (accidental) killing of Enishi's sister and Kenshin's first love, Tomoe. It actually works for a while, after Enishi convinces Kenshin that he (Enishi) had murdered Kaoru; in realiti Enihi couldn't kill her because she reminded him of Tomoe, so he took her prisoner instead. When Aoshi found out that the "Kaoru" who died was a puppet and Kenshin rescued Yahiko from one of Enishi's cronies, he recovered and decided to go rescue her.
- In .hack//SIGN the plot of the main villain involves a whole lot of this.
- Madara of Naruto successfully pulled one on Obito by maintaining Plausible Deniability. He mind-controlled various shinobi, including Rin, to create a situation where Obito would witness the death of the one person who made his life worth living. The ensuing despair made him the perfect accomplice for Madara's plan.
- It's later mentioned that Madara taught this tactic to Obito. In the anime there's a flashback showing Obito (successfully) pulling this on Nagato. He later tries it on Naruto, who manages to resist.
- A Certain Magical Index: One-Eyed Othinus tries to do this to Touma by attempting to make him feel worthless and a villain, by replacing him with someone else, who although different in large ways, has no effect on history, and how a simple change of perspective, without the assumption that he is a hero, turns his actions into that of a villain.
- In InuYasha, the Baby tried this on Kagome by giving her very cruel breaking lectures that hit her where it hurts the most for her: her love for Inuyasha, her insecurities towards Kikyou, and her fear of becoming Inuyasha's Unrequited Tragic Maiden. It almost works, but Kagome decides that even if her thoughts on Inuyasha and Kikyou are muddled, they're hers and the Baby has nothing to do with them, leading to a mix of Anguished Declaration of Love and Shut Up, Hannibal!.
- Lex Luthor defeats Superman in Superman: Red Son in this way: after every attempt to take out Superman by brute force fails, he attacks Superman's psyche instead with an Armor-Piercing Question.
- This sort of thing is done more than once. In Neverending Battle Manchester Black throws all of Superman's available nemeses at him then finishes up by killing Lois turns out the killing is a telepathic illusion. The point in this case is to try to get Superman to sink to his level via tragedy. Superman's allows the telepath into his mind to reveal there's a part of him that really wants to do that, but he doesn't succumb.
- Discussed in Justice. Superman says he's only as invulnerable as his most vulnerable friend or ally.
- The Joker has done this several times, such as in The Killing Joke and the film partially based on it, The Dark Knight. He does it either because that's the way he is or because he secretly, desperately wants to prove that everyone else is really as hopeless as he is.
- This is the entire reason Batman wears a mask. The safety of anonymity means that villains can't harm the loved ones who they don't even know about.
- Not only that, but its the reason most superheroes have a Secret Identity in the first place.
- Ozymandias convinces Doctor Manhattan that he's giving his acquaintances cancer in Watchmen, basically for this purpose.
- Following the death of his brother, the villain Kraven, Spider-Man villain Chameleon became increasingly crazy and devoted himself to putting Spider-Man through one of these, and along the way, he confirmed/learned Spider-Man's identity. This included convincing Peter he was in a Cuckoos Nest scenario and was actually an unhinged and depressed writer, as well as trying to attack Peter's family and friends.
- Mysterio finds out he's dying, crosses the Despair Event Horizon himself, and decides he wants a Taking You with Me "swan song" where he can drive Daredevil insane. It ultimately backfires, as Daredevil keeps a grip on his sanity, and after finding out who his enemy is and listening to his Motive Rant, turns the tables with a Kirk Summation that convinces the self-proclaimed "artist" that he's never had an original thought or spark of creativity in his life, and that he's "a human xerox at best". Mysterio ends up surrendering and committing suicide.
- Kingpin tries to do the very same thing, and much like the above example, it backfires horribly. With everything taken away from him, Daredevil no longer has anything holding him back, thus truly becoming a "man without fear."
- In the Magical Girl Crisis Crossover Shattered Skies, Joker wants to pull this on everyone, everywhere, in every universe... before he negates everyone and everything in existence, that is.
- In The Patriot the British colonel burns a church with its town inhabitants still inside and pillages towns. When the patriot militia descends upon one of the villages it prompts one of the soldiers who just lost his family to shoot himself in the head.
- Bane in The Dark Knight Rises is all about these. He even explicitly says so.
- In Harry Potter, the Death Eaters use this at least as a supplemental strategy, striking randomly at civilian targets to foster fear among the populace. Their targets are meant to be the impure and blood traitors, but by their standards that includes everyone who isn't a Death Eater or supporter.
- Once Sauron loses his body, this becomes one of his main tactics. In addition to the more overt Mind Rape of the Nazgûl and the intimidation tactics used at Pelennor (such as catapulting Gondorian soldiers' heads into the city), he twists the Palantíri so that his enemies gradually lose all hope of vanquishing him. This prompts Saruman to commit a Face–Heel Turn and start collaborating with him, and Denethor to send his own son off to die and commit suicide in the midst of the decisive battle. In the film, Denethor's condition is even worse, such that he refuses even to send for help and even orders his soldiers to abandon their posts.
- It eventually becomes clear that this is one of the Dark One's main goals in The Wheel of Time: hurt the Dragon personally until he turns or takes himself out. In The Gathering Storm, he succeeds, and Rand almost tries to unmake the world before he snaps out of it.
- In the novel Miracle Monday, The Devil's agent on Earth tries this on Superman (by trying to trick him into killing an innocent person) hoping to break his spirit (and in turn, the inspiration he provides humanity.) It fails because Superman just won't do it.
- Frankly, the elaborate revenge undertaken by The Count of Monte Cristo consists of his putting his enemies through one of these.
- In The Dresden Files, a fallen angel did this to Harry, convincing him to kill himself.
- This is Lord Foul's stock-in-trade in the Chronicles of Thomas Covenant. Unlike many users of this tactic, Foul is actually successful more often than not; a full list of the characters he has driven or nearly driven past their personal Despair Event Horizon would be far to expansive for this page, but the most notable would be High Lord Kevin in the backstory, whom Foul drove to despair and then convinced to use the Ritual of Desecration, which might defeat Foul, but would also wipe out almost all other life in the Land. As it turned out, it didn't defeat Foul or even really inconvenience him that much, but the bit about "wiping out almost all life in the Land" was entirely accurate, and Kevin died knowing that in his despair he'd destroyed everything he'd loved or fought for- just as Foul planned.
- In Worm Skitter realizes that since Omnicidal Maniac Scion has only just begun to feel human emotions he has no way to cope with his grief. So she throws reminders of what he's lost in his face until he's so bewildered and hurt they're able to take him down.
Live Action TV
- This was Azazel's plan throughout Sam Winchester's entire life in Supernatural, in an attempt to get him to agree to become Lucifer's vessel.
- Death brings back Bobby's wife as a zombie so he'll be forced to kill her a second time. Again, this is to break down Sam's support network.
- Warhammer and Warhammer 40,000 both feature Nurgle, the Chaos God of Pestilence and Despair. When mortals watch their loved ones wither from disease, or despair as their bodies bloat and decay from a hideous plague, they turn to Nurgle to escape the terror of their imminent death. Rather than cure them, Nurgle's blessings allow his followers to survive his disgusting attentions free of pain or fear, trading their immortal souls to preserve their disfigured and corrupted flesh. The process leaves Nurgle's followers with a morbid sense of good humor and eager to lead others into "Grandfather Nurgle's" scabrous embrace.
- In Knights of the Old Republic II: The Sith Lords, the protagonist actually uses this to defeat Darth Sion. His connection to the Force basically makes him invincible, so in order to kill him for good, the player has to convince him to give up that connection willingly and die.
- In Diablo III, several bosses try this on for size. Azmodan is hilariously ineffective at it. Diablo does better, though.
- In Shin Megami Tensei IV, the Omnicidal Maniac race known as the White dearly wish they could just wreck the Yamato Perpetual Reactor and just return Creation to the Nothing it was before to escape God's plans, but they have no real existence to do so; they need a physical proxy to do it. Thus, they pull a massive Despair Gambit involving three Alternate Timelines, the forces of Law and Chaos, and four Samurai, hoping that at least once, they will get the champion they need.
- In Baldur's Gate II, Bodhi tries to pull this on the Player Character by attempting to kidnap their love interest if they had completed a romance. The attack fails if you romanced an NPC from the Enhanced Edition, but succeeds with all original four love interests. The gambit fails, at least partly because Charname goes in for a Roaring Rampage of Revenge instead.
- RWBY: Salem's Image Song and her Volume 3 finale speech suggest that her plan is to destroy humanity by turning them against each other and sinking them into despair. Her goal appears to be to ruin Ozpin. She strongly implies that the only way to truly destroy humanity is to destroy Ozpin's faith in them and their future, but that Ozpin's faith will not be shattered until she has managed to destroy the hope and optimism his "simple soul" represents. The "simple soul" is implied to be the resolutely optimistic Ruby.