- Critical Research Failure: In Boston, Robby asks the dying Jimbo to tell her how he might have been infected. A doctor of her (or any) caliber should know that's going to be difficult for him to do with a breathing tube down his throat.
- Harsher in Hindsight:
- A real-life outbreak of the Ebola virus occurred in Zaire only a few months after the film was released. And then, later on, there was bird flu.
- And for the hat-trick, the most recent outbreak of Ebola in West Africa infected two Americans who were recently (at the time of this posting anyway) brought BACK to the United States. Clearly, no one who made this decision to do this had seen this movie... or any movie dealing with our favorite microscopic mass-murderers.
- Or perhaps they did. Those patients who were transported back were cured and aside from some slips in quarantine, there was no major outbreak in a population center. As of this posting.
- During that same outbreak, a Spanish missionary was brought back to Spain, which caused no end of controversy among Spanish public opinion. Not helping matters was the fact that said missionary not only didn't survive, but also managed to infect a nurse who became the first person ever to contract Ebola outside African soil. Fortunately, she recovered and no further infections were reported.
- There was a bit of excitement over Kevin Spacey, Dustin Hoffman and Morgan Freeman being together in film at last, which has faded due to all three of them being accused of sexual misconduct as part of the Weinstein Effect.
- Lampshaded in the legolambs episode ''Outbreak! The Musical'' in which the real outbreak isnt Motaba, but the Weinstein Effect.
- One-Scene Wonder: The White House Chief of Staff (played by the uncredited J.T. Walsh) is in exactly one scene in which he gives a speech that deftly balances Reasonable Authority Figure and Realpolitik.
- Retroactive Recognition: Dr. McDreamy started the titular outbreak.
YMMV / Outbreak