- Missing Episode: For no apparent reason, episodes 43 ("Father O'Mine" and "Everybody Loves Kuzco") and 49 ("Faking the Grade" and "Eco Kuzco") are never shown in the Disney Channel's rerun rotation. The Kuzcoween, Cornivale, and Giftmas episodes also fall under this, but it's because they're holiday episodes.
- The Other Darrin:
- J.P. Manoux replaced David Spade for the role of Kuzco. This also counts as Role Reprisal, since he previously voiced Kuzco on an episode of House of Mouse.
- Fred Tatasciore replaced John Goodman as Pacha. This was only for the first season, as Goodman was able to reprise his role in the second season.
- Pacha and Chicha's kids get new actors due to the previous ones hitting puberty.
- In the Japanese dub, Showtaro Morikubo replaced Tatsuya Fujiwara as Kuzco for obvious reasons.
- Real-Life Relative: At the time in the Japanese dub, Showtaro Morikubo and Yuu Asakawa (Kuzco and Malina's respective voice actors), were married—however, they're now divorced.
- Retroactive Recognition: Jessica Di Cicco as Malina, who would later go on to play Lynn and Lucy Loud on The Loud House.
Trivia / The Emperor's New School