- While Tim Daly had worked with Kevin Conroy and Edward Asner before when they guest-starred in Superman: The Animated Series, this is his first time working with Susan Eisenberg in a DC production as his involvement in the short-lived remake of The Fugitive forced him to be darrined by George Newbern as Superman for Justice League.
- Actor Allusion: Jim Ward, a co-host of the The Stephanie Miller Show, is the voice of the radio host we hear at the beginning.
- Role Reprise: Just like the first movie, Tim Daly and Kevin Conroy reprise the roles of Superman and Batman. Joining them in this outing are Susan Eisenberg as Wonder Woman and Edward Asner as Granny Goodness.
- In the French dub, just like the first movie, Superman and Batman are voiced by Emmanuel Jacomynote and Adrien Antoinenote respectively.
- Stunt Casting: Bruce Timm admits it's the reason behind most of the casting choices for the DC Animated series, including choosing Braugher over Ironside.
Trivia / Superman/Batman: Apocalypse