- Big Name Fan: "Fan" may not be the right word here, but Paul Rudd has been a significant factor in bringing the film to public attention through constantly airing a clip of the "wheelchair scene" as a Running Gag on Late Night with Conan O'Brien and later on Conan.
- Box Office Bomb: While the budget of the film isn't known to the general public, it made only $6,424,112, which wasn't even good enough to place in the top 100 grossing films of 1988. It limped to an 11th place finish in its opening weekend.
- Creator Killer: Everyone on the movie except director Stewart Raffill and composer Alan Silvestri. Christine Ebersole never took another lead role in a film after this, but has had a prolific career as a character actress and on Broadway, where she's won two Tonys. Plus, Martin Scorsese liked her enough to cast her in The Wolf of Wall Street.
- Disabled Character, Disabled Actor: The actor who plays Eric is Jade Calegory, who uses a wheelchair in real life himself. Prior to Mac and Me, Jade Calegory was a former spokesman for the Easter Seals charity for the disabled.
- Follow the Leader: Besides being an E.T. ripoff, the title of Mac and Me is one word different from an early working title for E.T., which was E.T. and Me.
- Stillborn Franchise: Its reception and reputation have guaranteed that these guys won't be "back" in any sequel any time soon.
- What Could Have Been:
- Reportedly, the early drafts of the screenplay had Ronald McDonald as a main character, as a sort of Mentor Mascot for Eric.
- Originally, the ending included some additional shots compared to the final ending which explicitly show Eric being accidentally shot in the back and killed by the officer who trips over his cruiser. These shots were removed for the US cut to instead imply that Eric died when the store exploded, but were included in a Japanese VHS cut discovered by film curator Peter Kuplowsky, who then posted the scene on Twitter.
- Kim Basinger and Anjelica Huston were each offered the female lead role. Both declined.
- Writing by the Seat of Your Pants: To quote the director:I was hired out of the blue. And the producer asked me to come down to the office. So I did and he had a whole crew there, a whole crew on the payroll. It was amazing. He had the transportation captain. The camera department head. The AD. The Production Manager. He had everybody already hired and I said, "Well, what's the script?" And he said, "We don't have a script. I don't like the script. You have to write the script. You're gonna have to write it quick so prep the movie and write the script on the weekends."
Trivia / Mac and Me