Spoilers Off applies to all "Moments" pages, so all spoilers are unmarked!
- Johnny's past regarding the death of his older brother Nicolas; he never stopped blaming himself for it where it's most likely not even his fault, and how his father blatantly favored Nicolas over Johnny, years after his brother's death. The latter is made all the more heartbreaking when it's clear that Johnny desperately wanted his father's affection."Ahh...God, you took the wrong son."
- This leads to an even more heartbreaking moment in High Voltage Part 2 where George comes to the final leg of the Steel Ball run clutching Johnny's boots to see his son disembark the ship with tears in his eyes, forcing his way in front of the crowd to make sure his son sees him and sees that he's there to cheer him on. Even Johnny's tearful at seeing his father come to make amends. Then George speaks up with the cherry on the heartbreak cake.George: Everyone. Everyone, please! Please listen to me. Please just for a bit, please listen to what I have to say. I've come here because I've treated my own child horribly for years and years. And the whole time up until now, I never realized that cruelty. I know that apologizing isn't enough to make up for scarring my child's heart. But that... is something I finally now have come to realize. My child's name is "Johnny Joestar". He crossed from the far-off west coast all the way across the continent. All by himself. And now! Here! He's finally made it to New York... (breaks down crying)
- What's more, the crowd seems to be icy faced to him pouring his heart out in support of his son, but then the reader is shown a little girl who starts clapping with tears in her eyes and further panels show the whole crowd is teary-eyed as they begin clapping at George's speech and in support of Johnny. Support he'd dearly need in his final battle against the alternate Diego.
- This leads to an even more heartbreaking moment in High Voltage Part 2 where George comes to the final leg of the Steel Ball run clutching Johnny's boots to see his son disembark the ship with tears in his eyes, forcing his way in front of the crowd to make sure his son sees him and sees that he's there to cheer him on. Even Johnny's tearful at seeing his father come to make amends. Then George speaks up with the cherry on the heartbreak cake.
- Diego's backstory, which includes his own mother basically killing herself to make sure he gets fed.
- Which leads up to the thought that... we do not know anything about Diego's backstory beyond that. Johnny claims he was not a good person, but Johnny himself was not only very jealous of Diego, it all came from hearsay. Plus when we see the two interact Diego himself seems pretty nice beyond the competition, despite Johnny disliking his presence. While we are predisposed to see him as just Faux Affably Evil thanks to Dio, there is no proof of so, and it would actually go against his mother's teachings in his backstory. It is very likely he was a perfectly nice guy that Johnny hated just because of his talent... before being infected by Scary Monsters and having it become his own stand, that is.
- In addition to that, the fact that Diego suffered basically the same fate as Dio. Both of them died from being cut in half.
- Ringo's backstory and death. He was a malnourished child who was in constant pain, his father dying in capacity, and lost his family to a man intended to rape him- leading to him awakening his power to have greater resolve. He then dies after a lengthy battle to inspire Gyro to accept the resolve to a man willing to kill in cold blood to get his objectives achieved.
- Hot Pants' backstory. When she was young, she and her younger brother were out hunting for nuts, they were attacked by a grizzly bear and cornered into a crevasse. In desperation, she would sacrifice her brother in order to survive, leading to her feeling intense guilt for her moment of weakness. And she would relive the trauma via Civil War's power.
- Wekapipo's backstory. He had a loving sister and had assumed she was living happily with her husband, but in reality, the brother in law was abusive to her. When he found about this, he would pull some strings to annul the marriage. Enraged, the former brother in law would arrange a duel between Wekapipo and himself, leading the latter's death. Wekapipo would then be arranged for exile under the pretense that he was dead to protect the reputation of the family. While in the United States, he found out that his sister apparently had died from falling down a flight of stairs, leading to the man losing all hope to become a ruthless assassin under Funny Valentine.
- Fortunately, he does find out that she was alive after all, but he is unable to do anything about it as Diego unceremoniously uses him to escape being subjected to the power of Funny's Stand. He had found a glimmer of hope, but circumstances ended them abruptly.
- While a villain, Magenta-Magenta is cast into the Delaware ravine, forcing him to use his Stand to avoid drowning to death. Unfortunately for him, no one comes to his aid, leading to him wishing for his then ally, Diego to save him. His wishes are for naught, causing the man to stop thinking as the isolation of being unable to die dawns on him. Unlike the case with Kars or Anubis, Magenta-Magenta was doing his job as an assassin and he then suffers a pitiful fate in kind.
- Gyro's death. We are treated to a close up on Johnny's visibly heartbroken expression, as well as a flashback to everything that had happened before. Johnny doesn't even scream out his name; everything happened so fast and he was so dumbfounded that he couldn't do anything but watch, teary-eyed and desperate.
- After killing Funny Valentine, he sees his ghost and the latter gives his farewells. This is followed by a several-page spread of their memories of building a strong bond.
- This is one series that constantly averts Real Men Don't Cry often, but this is probably the biggest and best example of this- Gyro's death tears Johnny apart inside, and he spends most of the final conflict with Valentine in tears. This from what was possibly the most stoic JoJo of all (aside from Jotaro and Giorno).
- There's one final gut punch right before the end: Marco, the boy that Zeppelli so desperately wanted to save from an unjust execution, manages to outlast the Kingdom of Naples, but dies shortly after of a cold of all things. Zeppelli's family, who'd served the King, had to disappear as Naples was absorbed into Italy proper. Everything that Gyro fought for wound up withering away right after he died.
- While he had become unsympathetic due to planning to use the Holy Corpse to make his own country safe at the expense of the rest of the world and had mocked Gyro's death, Funny Valentine is tragic as he didn't start off evil from birth, and in fact, used to be a carefree boy. He learned that his father died to protect the nation, inspiring him to do the same, with himself being tortured for the sake of the country's stability. He then found a piece of the Holy Corpse that awoke his Stand. His first actions was to attempt to bring back his father, but every time proved futile as it always ended in his death even in alternative timelines. His next best option was to secure the safety of the country that his father died to protect, even if the methods were morally bankrupt.
- In a way, the conclusion to the story of The Saint is this - starting with the man who makes the map (which makes Steel Ball Run possible to begin with), everyone he met on his journey east around the world - even when he makes it to America and continues his pilgrimage across a then uncharted continent - everyone he ever helped ultimately parted with him with the same words: Will we ever meet again?
