The series revolves a young woman named Beatriz "Betty" Aurora Rincón Lozano who moves to New York. For six months she's been trying to get a job, but she's always rejected due to her unattractive looks. One day, she finally gets a job at the fashion company V&M Fashion, where she becomes the secretary of the company president. Though it's below her capabilities and she gets ridiculed often for her appearance, Betty persists at her job.
Betty en NY provides examples of:
- Adaptation Name Change: Betty's name is given as Beatriz "Betty" Aurora Rincón Lozano. This is based on the original Colombian version, where Betty's name is Beatriz "Betty" Aurora Pinzón Solano.
- Bilingual Dialogue: Most of the show is in Spanish but it also has a large amount of subtitled English due to it taking place in New York.
- But Not Too Foreign: Betty en NY is an American production that is in Spanish. This explains why the characters live in NYC.
- Race Lift: Betty is Mexican-American, but the telenovela is mostly based on the original Colombian version of the franchise (not its Mexican counterpart La Fea Más Bella).