All spoilers are unmarked. You Have Been Warned

This franchise maybe about killer dinosaurs, but normally they are just animals trying to survive; humans, on the other hand, are plenty capable of evil, and some cross the line into monstrosity.

Novels

The Lost World: Dodgson crossed it before the book even started by testing a highly experimental vaccine on South American farmers without their permission or even knowledge as detailed in the first novel. This is even lampshaded In-Universe — the vaccine screw-up is mentioned as one of the greatest screw-ups Dodgson has ever done for Biosyn (because they didn't approve him testing the vaccine the way he did and had to waste a whole lot of cash and political power to keep the whole mess under wraps because he went behind their back) and the expedition to Sorna is his last chance to fend off a pink slip.

Jurassic Park:
- Gennaro crosses it by ditching Lex and Tim to get killed by the T. rex. Certainly fitting that he himself eventually falls victim to the same creature he tried to avoid.
- Nedry definitely loses any audience sympathy when he endangers the guests of Jurassic Park by shutting down the park's security in order to steal the dinosaur embryos for profit. His death at the claws of the Dilophosaurus was well-deserved.
Jurassic World: In the franchise's sole case where a dinosaur is this trope, the Indominus rex crosses it by brutally murdering the gentle Apatosaurus and leaving them to die in agony simply for sport.
Jurassic World: Fallen Kingdom:
- Already planning to sell the dinosaurs as weapons of war, Eli Mills crosses the line when not only he killed Lockwood when the latter protested, he also allows the sale for the Indoraptor, a highly intelligent and unstable killing machine who could kill many people if let out of contanmient.
- Wheatley crosses it when he betrays Owen and the rest, before leaving them behind on the island to die from the erupting volcano.
Jurassic World Dominion: The moment it turns out the giant locusts were made by Biosyn to devour crops not grown from the company's own transgenic seeds, threatening the world's food supply for greedy reasons, it's clear the company (especially its CEO, Lewis Dodgson) is the most vile thing to appear in the series.

Jurassic Park: Redemption: Peter Ludlow and Lewis Dodgson both cross it when they reveal their plans to let dinosaurs rampage across cities and frame it all on Peter's nephew Tim. Ludlow goes a step further when he sadistically points out that Tim's sister Lex will be one of the many victims.

Jurassic World: Camp Cretaceous:
- Mitch and Tiff cross it when they reveal their plans to hunt and kill dinosaurs on Isla Nublar.
- Daniel Kon crosses it by leaving his son, Kenji, to die on the seemingly exploding Mantah Corp Island to save his own skin.