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Demonic Spiders / The Binding of Isaac

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And this is just the beginning...
Nearly everything in the basement that moves (and a lot of things that don't) is trying to finish what Isaac's mom started. These guys try harder than most.
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  • The entire class of spider enemies are this both literally and figuratively. They all have erratic movements over random vectors, making it very likely they will collide into you for damage. Even the smaller spiders are dangerous because of this! The Baby Long Legs and Small Baby Long Legs are subclasses of Mook Maker spiders that will actively run away from you while spawning regular spiders (Baby Long Legs) or spider-spawning sacs (Small Baby Long Legs). Failure to kill these enemies quickly will result in the room filling with spiders, very dangerous in the early game when your damage output and tear firing rate are low.
    • Special mention goes to Trites. These jumping spiders are just like Hoppers, except they move at nearly double speed, take more hits, and often come in packs of four or more. Most importantly, they can jump about twice as far as Hoppers, and occasionally decide to jump a tile or two behind the player, which makes them impossible to dodge no matter what you do. The expansions even gave them a couple of variants: Raglings spit two orbiting shots around themselves in addition to jumping and are tougher, but fortunately aren't as aggressive. Blisters spit the same homing Dark Balls spawned by Little Horn, giving you a lot more stuff to dodge; to top it off, they used to have an absolutely ridiculous amount of health and could replace Ticking Spiders in the Basement, though thankfully a patch nerfed their health to only moderately above average.
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    • Lvl 2 Spiders and Ticking Spiders aren't far behind either. They can move as quick as a regular spider and jump like a Trite (though much less distance), and have around the health of the latter. Ticking Spiders also explode on death, making taking on them from afar the best thing (and still not guaranteed to work) to do.
    • Nests are variations of Mulligans that have almost double their health and spawn spiders. On death, they even spawn big spiders or Trites!
  • Leapers, the bane of any player going for a No-Damage Run (or playing The Lost). Their erratic jumping makes them hard to hit consistently, they can jump to any part of the screen with little warning, and when there's four of them, the screen tends to be filled with bullet spam from repeated jumps. A real pain to deal with.
  • Mr. Maws. They fling their head at the player if they come close, which can be very hard to dodge due to its speed, and upon death, they leave shooting Maw heads (and sometimes slow-moving Gusher bodies) behind which can be a problem of their own. Even bombs and Brimstone (unless buffed with extreme damage) won't get the head on the first hit. They can be the utter bane of people going for no-hit runs, because there's one room configuration that they are practically impossible to dodge as you enter. Mr. Red Maws are even faster variants which, when killed, leave behind a Red Maw head (which, granted, only fires one tear in each cardinal direction when killed).
    • Mr. Mines, stationary Flooded Caves-exclusive variants which launch themselves at nearby players, can burrow underground to pop up in another pit and release six shots in all directions upon death.
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  • Psychic Maws. They're a variant of Maws, which are already annoying enemies. These fire homing tears, have increased health, and have an Eternal Fly circling around them which can block hits. Fortunately, they are rather rare, typically only seen in late-game floors like the Cathedral.
  • Knights are Goddamned Bats at worst, but there exist two much worse versions of them. The Selfless Knight have Isaac's face in place of the brain and have massively increased speed, which allows them to charge across a room to you in under a second. Bone Knights are a Sheol-exclusive variant which leaves behind a thin trail of creep, making it difficult to get behind them without taking damage (barring that you have an item which grants creep immunity, such as Callus or some form of flight). They gain a speed boost, though they're not as fast as Selfless knights.
  • Starting with Rebirth, maroon Champions decay into piles of mush on death that can reform if not destroyed quickly enough, similar to Globins. Although ordinarily only slightly more annoying to deal with than the default version of that enemy, monsters that spawn enemies upon death will spawn that enemy (or enemies) every time they're reduced to mush. If that enemy is a tanky one or if your attack is low, you better hope you've got enough attack power to get through them before the Champion reforms, or you're going to be there a while. A maroon Champion Nest on Cellar I can end your run all on its own if you're not careful.
  • Eyes, especially when they're not located in the center. These stationary enemies fire Technology lasers which can cover an entire room and can ignore obstacles, making them highly likely to hit the player if they don't dodge out of the way during the split-second gap where they've locked onto them. Bloodshot Eyes versions are even more dangerous, as they fire Brimstone lasers which persist longer than the Technology lasers and are often situated between rocks, making it hard to hit them (especially without having a weapon to shoot over/through rocks).
    • There's even a Stone Eye variant, which constantly spins in a clockwise circle while shooting a Technology laser and will not stop firing until the room has been cleared.
  • I.Blobs, Isaac-like varieties of Clotties that behave in a combination of them and Clots: they fire 8-way blood shots, which makes even diagonal shooting dangerous depending on your items. Fortunately, they are extremely rare, but if you are unlucky enough to see one in a floor, expect to take some damage.
  • Chubbers. They have the same appearance as a Vis (the walking stomachs that shoot Brimstone lasers at you) but have a small, invincible Chub housed inside each of their bodies, which fires rapidly, can go through rocks and walls, and takes out a whole heart of health. It doesn't help that they have an insane amount of HP and often come in packs of 5 or 6. Made even worse in Rebirth: their Chub now blocks tears!
  • Vis are enemies that shoot Brimstone beams on your direction when they see you. Scarred Vis shoot them on your direction and behind them. But none of them take it to a level as grueling as Scarred Double Vis do. On mere sight of you, they shoot on all four cardinal directions. This leaves very little room to dodge. Keep your witz when you see these specific variants pop up suddenly in The Womb.
  • Keepers. They're the little bouncing Greed heads. They jump around erratically like Leapers, put you through Bullet Hell, and every single shot or collision with them makes you drop coins, making one lost forever. Much like spiders, they have the uncanny ability to squeeze between boulders and pits joined by one corner. They often come in packs of four, and Super Greed is all about spawning these.
  • Hangers, which are basically hostile shopkeepers. They fire three-way shots, have Eternal Flies circling them, and have a ton of health. Oh, and taking damage from them also makes you drop coins.
  • Masks + Hearts, which are essentially Knights with the brain separated from the body. The Mask is invincible and can only be destroyed by attacking its accompanying heart, which can soak a lot of damage. The masks charge and have very good reflexes, much like a knight, while hearts try to flee from the player, and fire four shots in the cardinal directions (like the Clotties) to defend themselves if they get too close. Fighting them in rooms with rocks makes them even harder to deal with, and they're rarely alone, often spawning in groups of three or more. Good luck dodging the extremely nimble masks while trying to get a clear shot at the hearts, which retaliate on their own accord.
  • Lil Haunt, the mook version of The Haunt, is an extremely cheap enemy. Their movement pattern is designed to lead you, which makes it very easy for them to corner you (but also extremely easy to control them if you know this). They have a bullet attack which has no tell or consistency. They are tougher than most mooks their size. Finally, they make the boss fight against The Haunt that much more annoying.
  • And, well, basically everything that can cause you to take damage in the Womb and Beyond, since they do one heart per hit instead of half, including spikes and Curse Room doorways (unless you have The Wafer or Cancer; the former reduces any and all damage to half a heart, while the latter only does so in a single room after taking damage).
  • Wall Creeps have two versions of these that will make you question any choice you make.
    • Rage Creeps fire Brimstone lasers. Here's the catch, since the last place you will look an enemy for is the walls (which they reside on), it's very likely you'll want to seize control of the center of the room. However, by that moment, Rage Creeps will likely had fired a beam that you'll be caught on (and sometimes get hit twice by it). And even discounting that situation, they remain very dangerous because their attack has short tell and infinite range.
    • The Things (Red Creeps) move at twice the speed of normal wall creeps and shoot a damaging trail of red creep about hallway across the room when they line up to you. It's extremely difficult to kill them without them doing this at least once, limiting your mobility. For an added annoyance, they constantly stick their tongue out when they're lined up with you, increasing the sizer of their hitbox so you can't get as close to them.
  • In Greed Mode, any enemy that likes to teleport/tunnel around the room (such as Lumps, Round Worms, and Wizoobs). The double-sized room makes these enemies much harder to track down and kill, which means that they'll often be still alive when the next wave spawns, essentially making you deal with two waves of enemies at a time. And if the Random Number God sees fit to saddle you with multiple waves of these guys in a row, good luck.
  • Also in Greed Mode, Death's Heads, the invulnerable enemies that bounce around the room and only die if the room is cleared. The problem with them in Greed Mode is that they only disappear once every enemy is killed, regardless as to which wave they spawned in from. This means that if you can't kill the other enemies in the wave that the Deaths Heads spawn in fast enough (quite likely given that they tend to spawn alongside tough-to-kill enemies like Walking Hosts), you'll end up having to deal with more enemies spawning on top of you, which means more things you have to kill to get rid of the Death's Heads. And the next wave that spawns could very well include even more Death's Heads, at which point you won't have much room to dodge and hitting something that actually takes damage becomes nigh-impossible.
  • Afterbirth added a skeletal version of Mom's hand which is approximately 100 times worse than the original. The original just flew down and tried to grab you. This one does the same, only when it lands, sends out several waves of rocks like The Cage, and releases spiders when it dies.
  • Afterbirth also gives us the Imp, which is basically what you get if you take a Baby, put it in Sheol/Devil Rooms, give it more health, make it actively try to dodge your shots, and make it shoot five times in a row. To top it off, these guys love to hide behind Satan's Statue in Devil Rooms to score cheap shots on you before you fully register the Imp's presence.
  • Afterbirth+ has the occasional Mimic Chest. There used to be no way to know in advance if they're spiked chests in disguise until you stand right next to them. Being forced to carefully check each chest when previously you'd just run into them was perceived as an unwarranted annoyance by most players. The design was thankfully changed to feature blood splatter and darker grey colour, making it fairly easy to tell at a glance.
  • The Mook Maker Portals in Afterbirth+ quickly became infamous. They're quite common, appear in pairs while surrounded by obstacles or other enemies, and summon a varied assortment of enemies at a fearsome rate. A nerf slapped these pretty hard after numerous complaints, making it so the portal has a chance of expiring on its own after each enemy summoned, made more likely with repeat summons.
  • You know those invincible Death's Heads that bounce around the room until you kill all the other enemies in it? Afterbirth+ adds Stoneys, Fatty variants resembling Grimaces which do an impressive job at being a hindrance. It comes in pairs or large groups and follows you around quickly, providing cover for the rest of the enemies. If those guys spawn at Greed mode, they'll more often than not last until the final wave of enemies and leave you next to no room for avoiding threats. The only saving grace is that they don't damage you on contact. It didn't take long for a nerf to hit them, making it so they have to catch their breath after chasing you for five seconds, which thankfully degraded them to Goddamned Bats.
    • Booster Pack 5 adds in the Cross Stoney, which are essentially Stoneys with a Cross Grimace for a head, which periodically fires four shots cardinally and diagonally. Thankfully, these are only encountered in the Aprils Fool challenge.
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