List of actors and actresses who appeared in MAD related media.
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Film
Up the Academy
Appeared in Up the Academy (1980):
- Candy Ann Brown: Nubia
- Robert Downey Jr.: Boy on Soccer Team
- Antonio Fargas: Coach
- Ron Leibman: Maj. Vaughn Liceman
- Ralph Macchio: Chooch Bambalazi
- Tom Poston: Sisson
Television
Mad TV
Appeared in MADtv (1995-2009, 2016):
- Ben Affleck: Himself
- Jessica Alba: Herself
- Anthony Anderson: Himself
- Pamela Anderson: Herself
- Jennifer Aniston: Herself
- Craig Anton: Home Owner/Bobby/Man in Toilet/Juror/Lars Stockham/Darren Farrell as Dad/Father/Senor Nino/President/Smuggler/Spishak Cola Advertiser/Various
- Christina Applegate: Herself
- Adam Arkin: Himself
- Will Arnett: Himself
- Tom Arnold: Himself
- David Arquette: Himself
- Tim Bagley: Schnitzer
- Alec Baldwin: Himself
- Ike Barinholtz: Lynette Scavo/Rolfe Gruber/Various
- Drew Barrymore: Herself
- Billy Barty: Himself
- Kathy Bates: Herself
- Warren Beatty: Himself
- James Belushi: Himself
- Halle Berry: Herself
- Jack Betts: Judge
- Beyoncé: Herself
- Rachel Bilson: Summer Roberts
- Jack Black: Himself
- Danny Bonaduce: Himself
- David Boreanaz: Himself
- Lara Flynn Boyle: Herself
- Wayne Brady: Himself
- Benjamin Bratt: Himself
- Spencer Breslin: Himself
- Jeff Bridges: Himself
- Todd Bridges: Himself
- Matthew Broderick: Himself
- Adam Brody: Seth Cohen
- Pierce Brosnan: Himself
- Brooke Burns: Herself
- LeVar Burton: Himself
- Jake Busey: Himself
- Amanda Bynes: Herself
- Bryan Callen: Judd Nelson/Various
- Neve Campbell: Julia Salinger/Herself
- Nick Cannon: Himself
- George Carlin: Mr. Conductor/Himself
- David Carradine: Himself
- Carlos Carrasco: IZM Terrorist
- Tia Carrere: Herself
- Katie Cassidy: Herself
- Kim Cattrall: Herself
- Cedric the Entertainer: Dr. Jekyll/Mr. Hyde/Himself
- John Cena: Himself
- Michael Cera: Himself
- Jackie Chan: Himself
- Don Cheadle: Perry/Himself
- Kristin Chenoweth: Herself
- John Cho: Himself
- John Cleese: Himself
- Curt Clendenin: High School Wrestler
- Glenn Close: Herself
- Stephen Colbert: Himself
- Gary Coleman: Himself
- Mo Collins: Miranda Hobbes/Cher/Various
- Harry Connick Jr.: Himself
- Jennifer Coolidge: Ivanka/Herself
- Rob Corddry: Johnny
- Courteney Cox: Herself
- Tony Cox: Mr. White
- Bryan Cranston: Mike/Himself
- Elisha Cuthbert: Herself
- Andy Daly: Dick Cheney/Various
- Carson Daly: Himself
- Rodney Dangerfield: Himself
- Blythe Danner; Herself
- Ted Danson: Himself
- Tony Danza: Himself
- Ellen DeGeneres: Herself
- Cameron Diaz: Herself
- Andy Dick: Daphne Aguilera/Various
- Snoop Dogg: Himself/Back Doe Johnson
- Illeana Douglas: Herself
- Fran Drescher: Herself
- Michael Clarke Duncan: Himself
- Colton Dunn: Man Dongo/Juan
- Jason Earles: Swirley Kid
- David James Elliott: Himself
- Robert Englund: Himself
- Chris Evans: Himself
- Jimmy Fallon: Himself
- Dakota Fanning: Herself
- Anna Faris: Herself
- Jamie Farr: Himself
- Terry Farrell: Herself
- David Faustino: Himself
- Jon Favreau: Himself
- Laurence Fishburne: Himself
- Joely Fisher: Herself
- Crista Flanagan: Opie/Webster's Representative/Anna the Mormon Wife/Miley Cyrus/Luanne Lockhart/Ethel/Lo/Brigitta Von Trapp/Various
- Maile Flanagan: Chastity Bono
- Calista Flockhart: Herself
- Scott Foley: Himself
- Matthew Fox: Charlie Salinger
- Vivica A. Fox: Herself
- Jeff Garlin: Hank Whitley/Himself
- Jennifer Garner: Herself
- Teri Garr: Herself
- Willie Garson: Lee Harvey Oswald
- Melissa Gilbert: Herself
- Whoopi Goldberg: Herself
- Bobcat Goldthwait: Himself
- Cuba Gooding Jr.: Himself
- Zachary Gordon: The Joker
- Mark-Paul Gosselaar: Det. John Clark/Himself
- Jack Frost/Prince Eric in MAD (2010)
- Gilbert Gottfried: Himself
- Crash/Father/LinKONG in MAD (2010)
- Dana Gould: Newt Gingrich
- Kelsey Grammer: Himself
- Brian Austin Green: White Chocolate
- Seth Green: Brightling
- Capt. America/Gordon Ramsay/Human/Jacob Black/Ranger Smith/Redcoat/Son/The Cat in the Hat/Werewolf Dad in ''MAD (2010)
- Tom Green: Himself
- David Alan Grier: Ed Bradley/Lunch Box Lewis/Various
- Pam Grier: Revolution/Herself
- Kathy Griffin: Herself
- Christopher Guest: Alan Burrows
- Tony Hale: Himself
- Mark Hamill: Mr. Swan/Himself
- Alyson Hannigan: Herself
- Chris Hardwick: Himself
- Neil Patrick Harris: Himself
- Melissa Joan Hart: Britney Spears/Herself
- Steve Harvey: Himself
- Tony Hawk: Himself
- Sean Hayes: Himself
- Patricia Heaton: Herself
- Jon Heder: Percy/Himself
- Simon Helberg: Various
- Jill Hennessy: Herself
- Charlton Heston: Himself
- Dulé Hill: Himself
- Dustin Hoffman: Himself
- Dennis Hopper: Himself
- Djimon Hounsou: Himself
- Ron Howard: Himself
- Kelly Hu: Herself
- Erica Hubbard: Double Dutch Rope Jumper #1
- Jay Huguley: Cop
- IceT: Himself
- Eric Idle: Zookeeper
- Milton James: Middle Eastern Man
- Orlando Jones: Various
- Jane Kaczmarek: Herself
- Jamie Kennedy: Himself
- Tom Kenny: Himself
- Gamorrean Guard/Rob Killmurder/Tom LaPille in MAD (2010)
- Keegan-Michael Key: Barack Obama/Various
- Taran Killam: Various
- Kim Kim: Mother
- Jimmy Kimmel: Himself
- Martin Klebba: Rich
- Jane Krakowski: Herself
- Mila Kunis: Daisy
- JayZ: Himself
- Caitlyn Jenner: Herself
- Ken Jeong: Passenger/Ken/Sung Chul Yang
- Don Johnson: Himself
- Dwayne Johnson: Himself
- Orlando Jones: Andre 3000/Various
- Phil LaMarr: UBS Guy Jaq/Michael Jackson/Various
- Artie Lange: Himself/Various
- Queen Latifah: Herself
- Denis Leary: Himself
- Bobby Lee: Kim Jong-il/Johnny Gan/various
- Stan Lee: Himself
- Bird Scientist/Papa Smurf/The Amazing Spider-Man Announcer in MAD (2010)
- John Leguizamo: Himself
- Richard Lewis: Himself
- Lisa Loeb: Singer in Hallway
- Lucy Liu: Herself
- LL Cool J: Self
- Eva Longoria: Herself
- Jennifer Lopez: Herself
- George Lucas: Himself
- Bernie Mac: Himself
- Scott MacArthur: Scott
- Seth MacFarlane: Peter Griffin/Himself
- William H. Macy: Himself
- Michael Madsen: Himself
- Bill Maher: Himself
- John Mahoney: Himself
- Howie Mandel: Himself
- Camryn Manheim: Herself
- Garry Marshall: Himself
- Penny Marshall: Herself
- Christopher Masterson: Lawyer
- Danny Masterson: Cop/Jon/Lawyer/Various
- Neal McDonough: Himself
- John C. McGinley: Paul a Post Worker/Himself
- Michael McKean: Jerry Palter
- Benjamin McKenzie: Ryan Atwood
- Christopher Meloni: Various
- Josh Meyers: Various
- Christina Milian: Herself
- Jay Mohr: Chris Penn/Himself
- Mandy Moore: Herself
- Frankie Muniz: Himself
- Taylor Negron: Himself
- Bob Newhart: Himself
- Jerry O'Connell: John Edwards/Various/Ted Levins
- Catherine O'Hara: Woman on Blind Date
- Shaquille O'Neal: Himself
- Tito Ortiz: Himself
- Patton Oswalt: Crip in Wheelchair
- Randall Park: Ando/Bobby's Cousin/Korean Man
- Vincent Pastore: Himself
- Josh Peck: Jeffrey Lutgz
- Jordan Peele: Various
- Michelle Pfeiffer: Herself
- Regis Philbin: Himself
- Lou Diamond Phillips: Himself
- David Powledge: Spot Welder
- Kelly Preston: Herself
- Freddie Prinze Jr.: Himself
- Michael Rapaport: Abraham Lincoln/Clark Gable
- Raven-Symoné: Herself
- Keanu Reeves: Himself
- Tara Reid: Herself
- Leah Remini: Herself
- Ryan Reynolds: Himself
- John Ritter: Himself
- Jeff Richards: David Letterman/Various
- Doris Roberts: Herself
- Tim Robbins: Himself
- Freddy Rodriguez: Himself
- Ray Romano: Himself
- Rebecca Romijn: Herself
- Portia de Rossi: Herself
- Busta Rhymes: Himself
- Susan Sarandon: Herself
- Will Sasso: Kenny Rogers/Bill Clinton/Various
- Richard Schiff: Himself
- David Schwimmer: Himself
- Ryan Seacrest: Himself
- Shakira: Herself
- Tony Shalhoub: Taxi Driver/Himself
- Harry Shearer: Mark Shubb
- Kiernan Shipka: Upset Child
- Pauly Shore: Himself
- Martin Short: Jiminy Glick/Himself
- Lise Simms: Executive #2
- Jaclyn Smith: Herself
- Jada Pinkett Smith: Herself
- Kevin Smith: Capt. Scurvy/Himself
- Sean Smith: Mourner #1
- Will Smith: Himself
- Brenda Song: Trick-Or-Treater
- Aries Spears: James Brown Jr./Talkin' American Host/Various
- Cole Sprouse: Kid
- Dylan Sprouse: Kid
- French Stewart: Himself
- Sting: Himself
- Nicole Sullivan: Vancome Lady/Antonia/Various
- Donald Sutherland: Himself
- Wanda Sykes: Herself
- Amber Tamblyn: Herself
- Jeffrey Tambor: Himself
- Justin Timberlake: Himself
- Christopher Titus: Himself
- Michelle Trachtenberg: Dawn/Herself
- John Travolta: Himself
- Verne Troyer: Himself
- Aisha Tyler: Herself
- Usher: Himself
- Wilmer Valderrama: Cop/Punch/Himself
- Gillian Vigman: Various
- Mark Wahlberg: Himself
- Ann Walker: Teacher
- Kate Walsh: Herself
- Adam West: Himself
- Bradley Whitford: Himself
- Fred Willard: Gene St. John/Self
- Barry Williams: Himself
- Debra Wilson: Oprah Winfrey/Rosa Marticorena/various
- Scott Wolf: Bailey Salinger
- Del Zamora: Saloon Drunk
- Robert Zemeckis: Himself
MAD
Appeared in MAD (2010-2013):
- Jason Antoon: Lex Luthor/various
- Diedrich Bader: Batman/Celebrities Without their Makeup Announcer/various
- Jeff Bergman: Car Driver/Daffy Duck/Various
- Steve Blum: Dewey Duck/Donald Duck/Huey Duck/Louie Duck/Teacher
- Mikey Day: Jacob Black/Spider-Man/Ash Ketchum/Freddie Benson/various
- John DiMaggio: Al/Announcer/Aquaman
- Grey Griffin: Ariel/Mom/Girl/Megan Fox/Various
- Will Friedle: Harry Potter/Capt. America/CM Punk/Various
- Aldis Hodge: Frog/Sinestro/Usher
- Tom Kane: Morgan Freeman/Narrator/Announcer/Various
- Matthew Lillard: Clinton Kelly/Creature/Shaggy/Various
- Beth Littleford: Announcer/Mother/Tasha
- Eric Lopez: Hikaru Sulu/Green Arrow
- Breckin Meyer: Green Arrow/Prince Zuko/Sean Parker
- Piotr Michael: Harry Potter/Announcer/Concierge
- Various in MADtv
- Rob Paulsen: Irish Scream Shampoo Announcer/Lex Luthor/Sheamus/Vendor
- Kevin Michael Richardson: Stacker Pentecost/Baby Jaguar/Mailman/various
- Ben Schwartz: Announcer/Jim Halpert/Narrator
- Brody Stevens: Cop/Gossip Girl Baby/Teddy Montgomery
- Tara Strong: Woman/Twilight Sparkle/Effie Trinket/Wonder Woman/Mecha-Thatcher/various
- Cree Summer: Neytiri/Sam Puckett/Thumper
- Fred Tatasciore: Announcer/Nicky Fury/Pres. Snow/Dominic Toretto/various
- Audrey Wasilewski: Gloria Pritchett/Grammy Norma/Thelma
- Michaela Watkins: Mom/Sam Puckett/Samus Aran
- "Weird Al" Yankovic: Krang/One Direction's Manager/Superman
- Frank Welker: Garfield/Fred Jones/Scooby Doo/Big Bird/various
- Billy Dee Williams: Attorney with Booger/Casino Guard/Lando Calrissian
- Henry Winkler: Jor-El
- Adam Wylie: Gen. Zod
