Also, in the manga Aion's plans are reveal to be a plot to destroy Pandaemonium (the demon's home) and "remake" the world. He succeeds in destroying Pandy and killing all of the demons but himself, Chrono and Shader, but Chrono and Rosette stop him before he destroys all of humanity.
In Pokémon, a flashback shows Saffron City Gym Leader Sabrina destroying her house with her psychic powers as a child.
The same effect (technically) happens to Kamille. The same also, being something of a remake, happens to Kira (again being a remake, having done the same thing as Amuro among other things to damage his colony beyond repair) and Shinn , through in Shinn's case it has a lot more to do with being bitter at ORB (for the death of his familly) than anything.
In Fullmetal Alchemist, Ed and Al burn down their house to symbolize how they'd never look back during their quest to regain their bodies. However, their father guesses that the true reason was to try to forget the shame of their failings.
Speaking of Hohenheim, he absorbed half the population of the empire of Xerxes when he became a living Philosopher's Stone. The other half went to Father.
Eva Heinemann in Monster does this to the Heinemann family mansion after realizing she cannot enjoy the life of a normal human being, then again, she isn't normal anyway.
Johan is another example
When Diva was finally "freed" in Blood+, she drank everyone's blood and set the whole mansion on fire. Though, given how she had lived her entire life up to that point locked up and used as a science experiment, this type of retribution is fairly justified.
Naruto: Uchiha Itachi massacred his entire family and clan in their private section of the village of Konoha. Zigzagged; while Itachi did kill his clan, it was actually a mission assigned to him by the village. The clan was planning a coup and Itachi wiping them out seemingly on his own let the village save face.
Later on Grace lured Vajra to Galaxy to get rid of those not involved in conspiracy
And Ranka's song seems to be luring to frontier, her new home.
Trigun features a couple of these. Most notably Knives blowing up the ship where he was born and brought up as part of his first attempt to kill off the human race; in the anime he manipulates and kills off the entire crew beforehand.
Manga Legato Bluesummers seems to have almost gotten himself killed as a child out of his determination to do this, instead of using his nascent mind-control powers to get the fuck away and run like hell. That Knives appears to have turned up and killed the whole town for kicks at the last moment is icing on the cake of rape-stopping and life-saving and electing-not-to-murder and tacit-acceptance-of-lifelong-fealty.
In YuYu Hakusho, Hiei was a male fire demon that was born among a female race of ice demons. Males can only be born to ice demons if they were birthed by an outside male. According to the ice demons beliefs, males bring destruction, so the elders had him thrown off a cliff. This is what caused him to want to destroy the ice demons, but it was subverted in the end. Why? Because when he finally found them, he realized that the ice demons had very pitiful lives, so decided that leaving them alive was a worse punishment. No wonder Hiei has a lot of social problems.
Yukina of all people is searching for her brother in an attempt to invoke the trope, believing he'll raze the place to the ground, and once asked Hiei to find him and give him the message not knowing that Hiei is said brother and had already opted for Cruel Mercy.
Ai Enma does this to her village after the events which led to her death.
The universe of From the New World centers around the development of psychic powers, particularly telekinetic, in humans. This power, called PK, is capable of doing many things, some of which we aren't even aware of yet. There's one thing most know for certain, however; that it is very dangerous. Those that contract a certain mental disease, called Hashimoto-Appelbaum Syndrome, have difficulty relating to their fellow humans and can lose control of their power. As you can imagine, this could lead to some pretty horrific circumstances. Shun, one of the main characters of the series, contracts the syndrome. His family is the first to die, before he completely annihilates his entire village and warps the rest of the landscape. Then, he strands himself in the middle of nowhere in some creepy, nightmare inducing, PK-altered landscape to record his experience before the Earth swallows him whole. Oh, and he was only fourteen.
And that's not even the worst of it. Boy K, a boy that lived long before Shun, had sociopathic thoughts and ideas, but behaved normally enough, so the community overlooked it. As it turns out, that was a terrible thing to do, because eventually something in him snapped. After brutally TEARING his teacher apart in the middle of a class lesson, he goes on a PK rampage, nearly wiping out the entire village, including his classmates, mere children, in scenes that were too graphic to show.
It's Lobo's own fault he's the Last of His Kind in both The DCU (where he killed all the other Czarnians on a lark) and The DCAU (where he fragged the rest of the planet for his high school science project).
Cletus Kasady, better known as Carnage of Spider-Man fame got his start along the path of villainy by burning down the Orphanage of Fear he was raised in.
Bizarro did this as well in the classic story Whatever Happened to The Man of Tomorrow?, destroying the Bizarro world due to him thinking he needed to do so to become a better duplicate of Superman. He then killed himself, for exactly the same reason.
In Carrie, the main character kills everyone at her prom, the two kids who had humiliated her, and her mother after prom night goes horribly, horribly wrong for her. They wanted to have her destroy the town, but didn't have the budget. In the remake, the damage is more severe.
At the end of Addams Family Values, Debbie reveals this is what she did to her parents, because they didn't buy her the right Barbie doll for Christmas. The Addams, naturally, are quite understanding.
The prequel comics and novel to 2007's Transformers movie all reveal, despite otherwise being separate continuities, that it was Optimus Prime, of all people, who launched the All Spark into space to keep it from Megatron's hands, dooming Cybertron to a slow, lingering death. In the movie itself, Optimus states that he's willing to sacrifice his own life to destroy the All Spark, if need be. Some characters think it's noble. Others think it's disturbing...
In the third film, Bumblebee is the one who destroys the Space Bridge control, resulting in Cybertron's destruction.
Elric of Melnibone destroyed his own empire after his cousin carried out a coup while Elric was traveling overseas. He then destroyed the entire world, eventually, although it was pretty terminally afflicted by Chaos already.
Carrie. The casualties number over 400 by the time she's stopped.
The White Witch from the Narnia series is revealed, in the prequel The Magician's Nephew, to have originally been Jadis, Queen of the world of Charn. When her sister rebelled against her, and came a bit too close to succeeding, Jadis used the ultimate magic spell, 'The Deplorable Word', to extinguish all other life on the planet. ALL of it. Then she petrified herself, awaiting a time when visitors from another world would intrude on her crumbling sanctuary...
Arguably, Petyr "Littlefinger" Baelish does this in A Song of Ice and Fire, selfishly kicking off the devastating War of the Five Kings because he was still bitter over being rejected by his childhood crush.
Theon Greyjoy spent a good chunk of his life as a glorified hostage in Winterfell. He would later conquer it in the name of his birth family though Ramsay Bolton was the one who actually razed it to the ground. He eventually regrets it after realizing that he truly thought of the Starks as his real family.
In the Annals of the Black Company, the man known as "Erin NoFather, an unlanded priest of the god Vancer from Slinger, in the kingdom of Vye" eventually became the Dominator. Of course, by that time he'd made sure to wipe the town of Slinger off the face of the earth, and kill everyone who had lived there while he was growing up, to prevent any of his enemies learning his true name. Later he laid waste to all of Vye.
Trapped on Draconica: Pre-story Zarracka summoned an emperor class fire ghoul in a desperate bid for hero-style praise and attention that almost trashed Britannia's capital. In the main narrative she is vital in Baalaria's victory over said capital.
Randall Flagg, Stephen King's oft reappearing villain, apparently hates his home country of Delain so much, he goes back every few hundred years and destroys it again.
In Red Dwarf, the titular ship suffers its accident because Rimmer hasn't fixed the drive-plate properly.
Doctor Who: The Doctor was only able to destroy the threat of the Daleks during the "last great Time War" by also destroying the other Time Lords and his home planet Gallifrey. Despite this, the Daleks and The Master have managed to survive. One of the surviving Daleks even went back into the Time War and ensured that Davros would survive.
Then the Doctor does it again in "The End Of Time" as we find out how the Time War really ended. The Doctor really did personally push the button that ended it and all involved, Time Lords, Daleks, and other horrors, and it was mainly to stop the Time Lords, not the Daleks, as they'd jumped off the slippery slope. Now that they'd returned, the Doctor had to foil their attempted resurrection, dooming them and Gallifrey to death in the Time War. The alternative was the destruction of the entire universe by the Time Lords, who wanted to start over as Energy Beings and the universe's only life forms - the same omnicidal plot (minus the Energy Being thing) the Daleks had tried in the previous season finale.
He also destroyed Gallifrey in the Eighth Doctor Adventures novel The Ancestor Cell, and, to be fair, it was for a good reason and they were being assholes anyway. He developed Trauma-Induced Amnesia as a result. Then it turned out that the amnesia was in part due to the fact Gallifrey had been kind of stored in his head. How's that for a "brain the size of a planet"?
"The Day of the Doctor" depicts the last day of the Time War when the War Doctor destroyed Gallifrey using the Moment. However after meeting the Tenth and Eleventh Doctors, the three decide to embark on a radical plan to change their own personal timeline, faking the destruction of Gallifrey by shunting the planet into another universe.
Captain Hero in Drawn Together tossed his home planet Zebulon into its sun in the episode "Little Orphan Hero," which was basically a parody of Superman's backstory.
Ben Linus from LOST told the main characters that he had lived on the island his entire life. In reality, he was brought there as a young boy by his father, who worked for the Dharma Initiative. He began consorting with the Hostiles and eventually participated in gassing the Initiative members.
The first Volume of Heroes was about a Petrelli family plot to have Peter nuke New York City, their home. In an alternate future, Sylar nukes Costa Verde, his new town, in a rage after his son is killed.
In Power Rangers RPM, Dr. K. is revealed to have created Venjix, just to keep her government 'caretakers' busy so she and her friends could escape. She didn't mean to, but...Doc K ended the world.
In a heroic example, Buffy the Vampire Slayer has, over the years, destroyed her high school gym (it was filled with vampires), her next high school (blown up stopping a giant demon-snake made of Mayor), and finally, her home town of Sunnydale (built on a gateway to Hell, caved in when the good guys destroyed it).
In a minor example, Parker from Leverage blew up her foster parents' house after they hit her and took away her favorite toy. No word yet on whether they were in it at the time.
Tobacco Road, written by John Loudermilk, and first performed by The Nashville Teens. It has been covered by The Animals, Jefferson Airplane, The Lovin' Spoonful, the Blues Magoos and David Lee Roth, among others.
Gonna leave, get a job with the help and the grace from above. Save some money, get rich and old, bring it back to Tobacco Road. But it's home, the only life I ever known. Only you know how I loathe Tobacco Road. Bring that dynamite and a crane, blow it up, start all over again. Build a town, be proud to show. Give it the name Tobacco Road
My Little Town by Simon & Garfunkel is a poignant memoir, but if you squint and look sideways at the final verse, it can take on some unintended meaning:
In my little town I never meant nothing, I was just my father's son Saving my money, dreaming of glory Twitching like a finger on the trigger of a gun Leaving nothing but the dead and dying back in my little town...
The Curse Of Millhaven by Nick Cave & The Bad Seeds - admittedly, she only razes part of it, but in the other verses the protagonist kills enough people to populate a small town.
And the fire of '91 that razed the Bella Vista slum That was the biggest shit-fight this country's ever seen Insurance companies ruined, land lords getting sued All cause of wee little girl with a can of gasoline Those flames really roared when the wind started blowing La la la la La la la lie Well the rich man, and the poor man, they all got to die
Wildfire by Sonata Arctica, a power metal band from Finland, is about a young man who does this.
Burn, honey burn, let the fire eat away I never liked the look of this town Burn it down now I'll run, they'll know what I've done I'll fetch my gear and take my leave from this mountain
In the Voltaire song "Bomb New Jersey", the singer is trying to arrange the nuclear destruction of his home state.
The song "A Rush Of Blood To The Head" by Coldplay:
You said, I'm gonna buy this place and burn it down I'm gonna put it six feet underground You said, I'm gonna buy this place and watch it fall Stand here beside my baby and the crumbling walls Oh I'm gonna buy this place and start a fire Stand here until I fill all your heart's desires Because I'm gonna buy this place and see it burn And do back the things it did to you in return
Nirvana imagine a blacklisted actress doing this in "Frances Farmer Will Have Her Revenge on Seattle".
In the Big Finish Doctor Who adventure "Orbis", The Doctor manages to destroy the world that has been his adopted home for the past six hundred years, and its inhabitants whom he was trying to protect. Whoops.
In Summoner, Joseph destroys the town he was born in in an attempt to save it, by summoning the Demon of Darkness to crush the army currently auditioning for the job. The demon decided not to stop after he'd slaughtered the army. This is why Jekhar, Joseph's childhood friend, now hates him. Joseph's second Doomed Hometown (dude is an overachiever) is also a source of guilt, since the army which destroyed it was after him, but he didn't do it himself.
Perturabo, primarch of the Iron Warriors, vented centuries of bitterness and frustration on his home planet Olympia after an uprising, almost wiping out the civilian population. Later, he had all life on the surface wiped out after a two-year siege., by loyalist Space Marines
The Night Haunter, the primarch of the Night Lords, spend his youth as a bloody-handed vigilante cleaning up the streets of his adopted home planet Nostramo by fear. On his eventual return, and seeing how the populace has slipped back into depravity, he uses his fleet to annihilate the entire planet.
Angron, primarch of the World Eaters, suffered as a gladiator-slave on the planet Nuceria. When he returned during the Horus Heresy, he and the Word Bearers took revenge by killing the entire population.
The player character of the PlayStation game Summoner. Arguably, twice. Before the game, when he was still a young boy, the player character used his summoning powers to defend his hometown, which was swiftly destroyed when the demon he summoned broke free of his control. The second time involves the "tutorial" level of the game, where the character's new hometown is destroyed by the invading forces of the enemy nation, in a war touched off because the emperor of said enemy nation received a prophecy that the Summoner would come and slay him, so the emperor decided to kill the Summoner first. This, of course, turns out to be a self-fulfilling prophecy, and the emperor turns out to only be a mid-game boss.
In Final Fantasy IV, after Cecil and Kain are tricked into burning down the village of Mist, young Rydia summons Titan in an attempt at a Roaring Rampage of Revenge but mainly succeeds only in finishing the job.
It doesn't end there, interestingly—at least in the DS version. Scenes from much, much later in the game strongly imply that orphan Cecil was himself born in Mist, meaning his first action in the game is to unwittingly and unwillingly destroy the place of his birth—at the command of Cagnazzo, who is himself at the command of Golbez/Theodor, Cecil's older brother, who spent his childhood in Mist as well.
At least in the SNES version(not the Bowlderized "FFII", though maybe even there), Mist wasn't actually destroyed: you can return via airship.
You can return to Mist in every single version of FFIV. Problem is, the only version that shows any damage to the town after the traumatic event is the DS version, where you can see the damage to some of the houses.
If you talk with the inhabitants there, they will reference the horrible disaster that killed all of the summoners. Maybe Mist had two significant populations: the world's only summoners, and the world's best carpenters.
In Final Fantasy XIII Fang and Vanille do this to their hometown of Oerba, when they turned into Ragnarok at the orders of the fal'Cie; and all the other Pulse societies went with it.
Psycho Mantis from Metal Gear Solid destroyed his home village during what can only be described as a psychic temper tantrum.
Discovering your father blamed you for your mother dying in childbirth, generally hates you, and harbours the secret desire to kill you, would make the resulting trauma amount to a bit more than a tantrum.
In Metal Gear Solid 4 Laughing Octopus was forced to participate in the massacre that killed everyone else in her hometown by personally torturing her entire family to death.
Bishop from Neverwinter Nights 2 will admit to burning down his hometown if the player's influence score with him is high enough. He actually tried to warn them ahead of time (it was a trap for his Luskan 'allies'), but they didn't take him seriously enough to do anything about it.
In Overlord II, the titular Overlord's hometown of Nordberg is the first town you conquer; you'll either wind up enslaving them all or leaving the entire village as a smouldering heap of wreckage.
Fallout 3: The Lone Wanderer can sabotage Vault 101 to make it uninhabitable, forcing all the residents outside. Or nuke Megaton, the first major town visited after leaving the Vault, and where James and his infant child stopped by on their way to the Vault. Also, he/she can sabotage Project Purity, located in the building that he/she was born in, effectively turning it from the waters of life to the waters of death.
Fallout: New Vegas. An early, somewhat difficult to find sidequest allows you to side with the Powder Gangers and massacre everyone in Goodsprings. Technically, Goodsprings isn't the Courier's hometown, but it's close enough.
The Lonesome Road DLC reveals the Courier was unintentionally responsible for destroying The Divide. Twice. With nukes.
Breath of Fire: Cerl, one of the Dark Dragon Generals, uses the Time Key to freeze her old hometown. When she was younger, they kicked her out due to Fantastic Racism; the only person she spares is her childhood friend Alan, who never agreed to the exile but was powerless to stop it.
Dawn of War, in the back story Gabriel ordered the Exterminatus on his own homeworld Cyrene when he discovered corruption among the recruits.
Should you choose to follow the Demon Path in Soul Nomad & the World Eaters your first act of evil is to, of course, kill everyone in your village.
A dual-wielding example in Star Trek Online should you choose to play on the Romulan Republic side. Your future First Officer, Tovan Kiev, was born on Romulus before destroyed by the Hobus supernova. Your character lived on Virinat (and can choose if you lived there before said destruction or after) before it is razed by the Tal Shiar and the Elachi.
In Shin Megami Tensei IV, this happens to the Eastern Kingdom of Mikado through slightly different flavors in both the Chaos and Neutral paths. In Chaos, by destroying the angels who have replaced the kingdom's rulers and blasting Naraku open, Mikado descends into anarchy. In Neutral, you have to order the entire kingdom's evacuation for events to unfold. Let's just say that the original settlers could have chosen the site for their castle much better.
In Mass Effect 2, Jack's loyalty mission is to help her find some small amount of closure on her traumatic childhood, by destroying the abandoned Cerberus facility on Pragia where she was tortured and experimented on.
Depending on your choices, it's very possible for your heroes to wind up destroying part of their hometown before The Yawhg ever arrives.
In Fine Structure (Power of Two being the first in the arc) the Powers gain their power when they're hit by a very painful lightning bolt that makes them go berserk for about fifteen seconds. One of their superpowers is speed, so a lot of people can die. Also, that website started as a howto on destroying the Earth.
Nocturn, the warlord Ehlek's lieutenant in BIONICLE got sent to The Pit for "breaking" his island in a fit of rage. When the author Greg Farshtey got asked why he did this, he answered: "People break things when they get angry. Nocturn happened to break his island." Apparently he hit a weak spot For Massive Damage.
One (and a half) villain in The Wotch was ostracized by his village of reindeer because he was a were. No, not a werewolf, a harmless were-girl. When he/they came back from a quest for an artifact allowing him/them to control the change, the townsfolk reacted even more violently, leading to an inevitable, but deserved, massacre.
The Uricarn Demon killed all the other members of his species. He comments that he probably should have thought it through a bit more, since he didn't discriminate by gender. Cue daydreaming about the time Anne fought him after transforming into a very accurate and very female Uricarn demon.
Also Durkon might do it too, by accident, given a prophecy that he knows nothing about.
In Superman: The Animated Series, Superman's old foe Brainiac got a new origin: instead of a mad scientist from the planet Colu, he was an intelligent supercomputer from Krypton. When Jor-El shared his fears that the planet was going to explode, Brainiac probably could have done something about it — but he lied and said Jor-El was wrong, while secretly plotting his own escape. Being the last holder of knowledge about a whole world appealed to him. In fact, he liked the idea so much he started doing it to other worlds too.