"Hey, Doctor Luce — this proteus nanovirus — isn't it supposed to, you know, go out of control infecting and transforming everyone, and like that?"
"Of course not. Not unless you design it to. Here's how."There are forces, be they biological, mystical or technological, that can infect and change a person into something — else. These tend to be highly contagious, spreading easily via physical contact, bite, ritual, or other means. The changes are seldom subtle, and often quite a shock for the victim, who will likely wonder what they have become. On the plus side, the Viral Transformation is usually Cursed with Awesome, giving the "victim" Stock Superpowers and the ability to give them to others. By now you're probably wondering what the downside is to this, and why this "disease" hasn't been shared among all of humanity. Well, it's usually because it makes the transformees jerks. While it's not (always) The Virus, making those infected into Always Chaotic Evil, Mind Controlled servants to a Hive Queen who gladly eats puppies, it does lend itself to "Power Corrupts". Though the changes are mostly physical, the alterations may cause a change in perception because The Mind Is a Plaything of the Body, their new body has a Horror Hunger only sated by eating orphans (and it tastes good!), and With Great Power Comes Great Insanity. Those responsible for infecting the victim may expect a Face–Heel Turn because the shock at the change will make them run to others like them, as well as Fantastic Racism making it likely they'll be alienated by their friends and family (this is especially likely if the transformation is less than cosmetically appealing). However; the choice to do so remains with the victim: they can consciously choose Transhuman Treachery, to stand apart and above of humanity, become Fully Embraced Fiends who enjoy their condition, to be Friendly Neighborhood Vampires and live among if not entirely in harmony with humanity, or even be a Pro-Human Transhuman and act the Sheep in Wolf's Clothing while becoming a Vampire Hunter. Common examples of this include most forms of Lycanthropy and some forms of Vampirism. Expect those affected by a Viral Transformation to be tempted to help friends or loved ones with an Emergency Transformation or surprised when a blood donation turns into a Superhuman Transfusion. See also Virus Victim Symptoms. See also Warm Bloodbags Are Everywhere. Compare The Corruption. A type of Face–Monster Turn.
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- Blassreiter. After being infected with body-modification nanobots people become Made of Iron and can meld with various hardware, but generally also turn into omnicidal maniacs with hallucinations and/or damaged memory. Because the "Pale Rider" line of nanobots was designed this way and to that end. An original project was purely medical.
- Used in the Manga series Dragon Eye, when the villains are created when the D-Virus changes them into a monster known as a Dracule. Anyone infected loses their identity and goes on a killing spree. Only a few, (about one in a hundred/thousand) have the antibody resistance that changes chance of infection from 100% to 10-0.1%.
- The Eclipse infection in Magical Record Lyrical Nanoha Force. The good news is that, when infected, you gain powerful magic, Healing Factor, Anti-Magic, inexhaustible endurance, and a whole buttload of other stuff. The bad news is that, if you want to keep your life and sanity, you need to keep on killing to keep the infection in check.
- Becoming an Homunculus in the world of Busou Renkin sounds great - increased strength, a range of superpowers, Immortality, immunity to disease... but the fine print is that your diet now consists of people. And if you're not a super-special-awesome Human-type Homunculus, you go insane and become dominated by your instincts.
- Scary Monsters, the Stand-ability of Doctor Ferdinand from JoJo's Bizarre Adventure: Steel Ball Run infects any living creature with a virus that turns them into a dinosaur under Ferdinand's control. Then the virus is spread by the dinosaurs themselves to practically create a zombie infestation... of dinosaurs. Diego Brando is later able to keep and control the infection on him due to obtaining the Saint's eye but Diego's version seems to lack the infecting properties.
- In Uzumaki, most of the spiral transformations more or less come from out of nowhere and only hit a selected few individuals. However, the snail transformations seem contagious in their own way. The ones that start transforming into snails in the first place are always people who are physically slow, and then the ones who in any way hurt the snail people and/or their eggs will also be turned into snails.
- In Attack on Titan, Titans are humans transformed through some unknown means — Eren appears to have gained his powers through an injection, while the Beast Titan employs an unrevealed method to transform an entire village. The majority are rapidly absorbed by their Titan form, becoming mindless horrors that devour other humans. However, some have control over it and gain a Lovecraftian Superpower with none of the urge to devour humans.
- The Brood from Marvel comics propagate their species this way. They inject parasites into viable hosts (which is basically everyone) that gradually transform the hosts into more Brood. By the time the transformation's complete, the original psyche of the host is all but gone. Incredibly, despite being (nearly) Always Chaotic Evil, it's still possible to pity the Brood because this is the only way they can reproduce.
- Druuna comics have diseases that change people into tentacled monsters. But, this being a Porn with Plot comic, you can probably guess what happens next.
- The "Monstar Virus", pretty much Exactly What It Says on the Tin, in the Amory Wars. Used to turn Coheed and Cambria into "The Monstar" and "The White Ruineer" respectively.
- From the DC universe, the rare West African virus Sakutia, upon infection, will transform the user by turning their skin and hair green. Some varieties will also grant the ability to transform into any animal. This is the source of the powers of Beast Boy. Most varieties are inevitably fatal.
- George A. Romero's films cemented this concept with zombies and pretty much birthed the entire genre of the Zombie Apocalypse. Many many many works have followed since.
- Creepshow segment "The Lonesome Death of Jordy Verrill". After the title character is infected with liquid from a meteorite, he slowly changes into a fungus creature. He manages to end his suffering by committing suicide with a shotgun. The infection is later shown spreading across the countryside, creating a beautiful verdant landscape.
- The plot was obviously copied from H. P. Lovecraft's The Colour Out of Space.
- Underworld has examples of both this and The Virus. The original flavor werewolves under William were all raving savages, but those who inherited it from Lucian spend most of their time in human form, and can eventually enter or leave were-form at will.
- Then you have the various takes on the hybrids. The movies show two different hybrids (Marcus and Michael) and mention a third (Lucian and Sonya's unborn child). The first two involve a member of one species getting exposed to the blood (and virus) of the other. While the viruses normally annihilate each other, the presence of the "Corvinus strain" in both allowed the viruses to merge into something new. In Michael's case, his original Lycan strain retained dominance, making him appear vastly more human than an average Lycan. Marcus, who started as a vampire, attained more bat-like characteristics, although he did gain several Lycan ones as well. It is unknown what Lucian and Sonya's child would look like, given that it was equal parts Lycan and vampire, or if it would survive at all, given the mutually-destructive "relationship" the two virus strains have.
- In District 9 this happens to the main character after being sprayed with the alien "Fluid."
- In the 2001 Sci Fi Channel telefilm "Threshold" an astronaut infected with alien DNA let loose moth-like carriers that infected other people. The government found the hybrids all had B negative blood and, furthermore, the hybrids had stolen a list from a blood bank so they could track down their targets. The title comes from the other governments of the world declaring the invaders had to be stopped before they reached a critical population or Southern California would be nuked to stop them.
- In Daybreakers, humans are turned into vampires through a virus.
- The Wolfman (2010) has lycanthropy transmitted this way via bite. In an interesting case, it goes from father to son when the protagonist is bitten.
- The Lazarus Effect in an unusual case, being resurrected with a special serum has the side effect that the person brought back keeps making it. If they get a second injection, they can start producing it on their own, and if there's anyone near they want to resurrect...
- This is the basis for the Wild Cards series of books. An alien virus gives some people super-powers and transforms others into "Jokers", who are sometimes not even recognizable as having been human. Well, at least if your particular draw included the ability to infect others. Despite the fact that xenovirus takis-A was a literal virus, it wasn't (normally) communicable.
- Shriek: An Afterword: The fringe historian Duncan Shriek is the only human to discover a safe method to enter the underground realm of the Graycaps under the city of Ambergris, but this involved getting an esoteric fungal infection, which would in the course of the years transform him into a man-fungus hybrid who could only retain human shape through constant mental effort. The novel also features common people getting less extreme, though still bizarre-looking fungus infections out of the fungus bombs used during the civil war. And the sequel, Finch, has Partials, people who voluntarily go through this process to become akin to fungus cyborgs.
- In The Relic by Douglas Preston and Lincoln Child, a reovirus creates monsters out of anything that ingests it by inserting saurian and reptilian DNA into host cells; but the victim needs a steady supply of specialized hormones to retain its new form, the victim-turned-monster; in order to acquire these hormones, the victim must go right to the richest source available and eat the hypothalamus of its victims or go mad from the pain of being unable to sustain its new form.
- It's very common in zombie novels for the zombification to be caused by a virus, the most famous or at least one of the earliest probably being I Am Legend, both the book and movies.
- In The Maze Runner Trilogy, Cranks, zombielike victims of the Flare, end up becoming more and more undead-like in physical appearance as they spiral into madness. Specifically, their hair and some of their teeth fall out, gashes and patches of blood appear on their skin, and black veins begin to snake down their limbs. Newt gets the symptoms rather severely when he becomes a Crank in The Death Cure.
- The virus in Galaxy of Fear: The Planet Plague turns people into Blob Monsters which infect any bare skin they touch. The virus itself gets shown in a microscope-equivalent and is deliberately being tested and spread, to see how many species barriers it can jump after being modified.
- In The Mortal Instruments, this is common from exposure to angelic or demonic influences and/or bodily fluids.
- The Shadowhunters received their special abilities from drinking the blood of the angel Raziel given to them in the Mortal Cup. New Shadowhunters can also be created this way, although the process is risky. Jonathan Morgenstern arranged the creation of the Infernal Cup, tainted by the blood of Lilith, which can turn humans and Shadowhunters into Dark Shadowhunters.
- Consumption of angel or demon blood generally, even in dried form, can result in changes to a person or their offspring. Valentine, Jocelyn, Clary, Jace and especially Jonathan were all altered to some extent in this way due to Valentine's experimentation with the blood.
- Vampires and werewolves are the descendants of two different species of demons. They can transmit their condition to humans, and even Shadowhunters, via bite.
- Vampire Academy:
- This is the only way that Strigoi vampires can reproduce, by biting Moroi, dhampirs, or humans. First they drink the subject's blood, then share their own blood with the drained subject. The subject then turns into a new Strigoi, a transformation which the Strigoi call "awakening". The process can be involuntary for the subject.
- There are exceptions in the cases of Moroi vampires who turn into Strigoi by themselves. They only have to kill a victim by draining it of blood.
- In Eden Green, an alien needle symbiote spreads across a small group of humans, gradually taking over their bodies as it heals their wounds. Each infectee can eventually reach milestones at which their brain and even entire body is made up of needles, with horrible mutations possible along the way.
- Doctor Who; The Empty Child/The Doctor Dances has people being transformed into zombie-like beings with gas-masks fixed on their heads. The cause are alien medical nanorobots unfamiliar with humans, who took the first being encountered (a dead gasmasked boy) as a base template, and are now trying to "fix" the "sick" people. The problem is solved when the original boy's mother reveals herself and embraces her child. The nanobots figure out the correct human template and then quickly undo the damage.
- The Waters of Mars sees people touched with infected water turned into zombie like creatures that spray more infected water to spread the virus further.
- And the cliffhanger for The End Of Time part 1 has The Master utilizing a device called the Immortality Gate to turn every human being on Earth into versions of The Master (except for Wilfred Mott, whom the Doctor placed in a radiation-proof chamber and Donna Noble, who became half-Time Lord thanks to the events at the end of Series 4.
- In the classic series, we have the Krynoids. A Krynoid is a monstrous plant that converts animal organisms into Krynoids by touch. Two men were converted in the Krynoids' debut story, The Seeds of Doom not be confused with the earlier story The Seeds of Death. This so outraged Mary Whitehouse, a media watchdog, that she spoke out about the "obscene vegetable matter" being shown on Doctor Who, which she dubbed "teatime brutality for tots".
- Of course the Vampires from Doctor Who story State of Decay. Also the Haemovores, who are basically zombie-like aquatic vampires.
- The Stargate-verse loves this trope.
- Stargate SG-1: A virus caused people to turn into cavemen (a minor version, it just gave them funny foreheads and heightened aggression). A nanotech version made O'Neill 100 years old in a few days. Teal'c was bitten by a bug whose venom would have converted his total body mass into more bugs.
- Stargate Atlantis: The Iratus bug retrovirus designed to "cure" Wraith does this. First it turned a female Wraith and then Sheppard into human/bug hybrids. Once perfected, it turned Wraith into humans. Michael, one such victim, took it and used it to make Wraith/human hybrids.
- Stargate Universe: Chloe was infected with a virus by some aliens which appears to be turning her into one of them, or something close. At first it was mental, but then things got worse.
- Towards the end of Maddigan's Quest, it's revealed that Timon was injected with a virus based on the Nennog's DNA before being sent into the past. Once activated, it begins the job of turning him into the heir to the Nennog, granting him superhuman abilities, turning him evil and making him... less than entirely attractive (but, oddly, also more flirtatious than before).
- Ilyria was played as a variant of this on Angel, infecting Fred after she inhaled dust from Illyria's sarcophagus and then turning her slowly into the shell.
- Star Trek: Enterprise reveals that the Klingon loss of forehead appliques in Star Trek: The Original Series was due to a Viral Transformation, and that they could eventually get better and regain their forehead appliques, in time for Star Trek: The Motion Picture (and the other early 80s movies) and Star Trek: The Next Generation.
- Teen Wolf: Scott becomes a werewolf once Peter Hale bites him in the woods.
- In Season Two of Supergirl, J'onn discovers that a blood transfusion from a White Martian is now causing him to turn into a White Martian.
- Cybergeneration, a sequel to Cyberpunk, is run on the premise that a nanite infection will kill anyone over the age of 16. If you're under 16 you survive... or change.
- In Werewolf: The Apocalypse werewolves and most other werebeasts are actually hereditary rather than contagious. But were-ravens and ratkin both transform normal humans (or animals) rather than breeding. Ravens by creating a "spirit egg" that they bond to a child or fledgling, ratkin using a rite that usually kills the prospective ratkin.
- The process of becoming an Amorphage in the Yu-Gi-Oh! card game involves a scaled up bacteriophage attaching itself to your body and dragonic body parts sprouting from your body. In some cases, the transformed retains characteristics of its previous self such as Olga having its original head on top of its new one.
- Shadowrun: The "Cognitive Fragmentation Disorder" seems to work this way, with the new AI building technological parts out of nanites in the host.
- The Reapers from the Mass Effect series possess this ability. While they are content with simply killing all intelligent life that opposes them, their main goal is to "harvest" those they abduct and use their genetic material to make more Reapers. Besides the two-kilometer-tall Capital Ships, they also mutate individuals into ground forces, and once a ground force troop manages to bite/scratch an individual, the attacked begin transforming into a Reaper ground troop themselves.
Garrus Vakarian: It ensures you never run out of cannon fodder. Eliminates any local resistance. And for every soldier you add, your enemy loses two: the one you converted, and his buddy on the other side who can't pull the trigger on a friend.
- Members of the Many in System Shock 2 undergo this, tending to leave behind a lot of Apocalyptic Logs. While some engage in Transhuman Treachery, a large amount of the creepiness is delivered by the poor Red Shirts who beg you to flee while they're unwillingly chasing you.
- In Lost Souls MUD, a local implementation of NetHack's "eating a mind flayer makes you smarter" makes it so that eating the neural tissue of the vlekthid (read illithid) or gogtzul (read Star-Spawn of Cthulhu) races results in that neural tissue colonizing your own nervous system, making you smarter and less emotional, and giving you both psionic powers and often-crippling mental disorders.
- Borderlands' first expansion, the horror movie themed The Zombie Island of Dr. Ned, has both zombies and Wereskags (skags being the planet's equivalent to dogs/wolves). Both transmit their infection/curse via bites.
- Albert Wesker of Resident Evil is infected with such a virus. It is not particularly transmissible, but it does make him something of an unstoppable badass.
- Redlight and Blacklight from [PROTOTYPE]. Redlight is a completely straight version of The Virus, which transforms people into braindead, malformed husks serving Elizabeth Greene, while Blacklight is a Viral Transformation. The player character, Alex Mercer is essentially a corpse reanimated by Blacklight, and although he is a Jerkass Anti-Hero with horrifying powers, he's significantly less evil than the real Alex Mercer was in life.
- Everyone is infected in Left 4 Dead. If you're lucky, nothing about you changes and you become a carrier/survivor. If you're unlucky, you become a common infected. If you're EXTREMELY unlucky, you become a special infected.
- Mitochondria Eve of Parasite Eve fame is basically a sentient and controlled version of this by manipulating the mitochondria cells in any biological lifeform, whether it be man or beast. The beasts get some pretty wicked transformations. The humans however...not so much
- Played for laughs with Australium from Team Fortress 2, which induces Testosterone Poisoning upon those who use it. Specifically, this causes men to become incredibly muscular and grow impressive body and facial hair. As such, Australians in the setting are a race of hyper-advanced Boisterous Bruisers with mustachioed women.
- In The Elder Scrolls series, Vampirism and Lycanthropy are actually diseases (though divine in origin) which can be spread via any wound inflicted by a carrier of the disease. In the case of vampirism, it starts off fairly innocuous (fatigue, insomnia, nightmares) and is easily cured within the first few days of being contracted. Porphyric Hemophilia, Sanguinare Vampiris and Noxiphilic Sanguivoria are a few of the diseases that develop into full-blown Vampirism. Lycanthropy functions similarly, although in some cases consuming the blood of a lycanthrope can cause the disease to immediately take effect.
- In El Goonish Shive, whoever touches the Dewitchery Diamond while under a "curse" (for a very loose definition of a curse) will be split into their normal state and a duplicate who not only is the embodiment of the "curse" as applied to the original person but who can spread it to others no matter what the nature of the curse is. Fortunately, if the "curse" is easily reversed, the people the duplicate transforms can have the transformation reversed just as easily.
- It's not exactly clear where all the "devils" in Sinfest came from, but at least some of them were originally human, and one of those has shown the ability to transform animals into their demonic equivalents. (Similarly, holy power can turn a devil human. The strip's version of Jesus spends a lot of time undoing transformations that its version of Satan has inflicted.)
- In Be Calm, it quickly becomes apparent that being exposed to the air in the underground facility for too long can have seriously bad effects. Namely, mutating your body until you turn into a monstrous killing machine. The ARG attached to the reboot hints that part of the facility's original purpose was to figure out a way of studying these mutations in a controlled environment.
- Sssnake Eyesss, a short comic by The Shadow Demon on DeviantArt, has a legendary snake (in a zoo for some reason) whose stare will turn you into Snake People. Who inherit the trait. A girl subjects herself to it as a Scare Dare, naturally discovers the legend to be true and accidentally spreads the condition to bystanders in the sequel. (The one guy enjoys it and proceeds to fertilize some eggs.)
- The Rugaru in Wilde Life causes anyone who sees it to transform — rapidly, agonizingly, and irreversibly — into another Rugaru. This horrifies Cliff when he realizes that the monsters he killed to save Oscar used to be human.
- A Shared Universe called The Blind Pig - and its reboot/successor Pig and Whistle - take place after a virus with unknown origins spreads throughout the Earth. A lot of the people who get it die. Some percentage of the survivors transform. A smaller percent of them get unusual abilities.
- The Paradise setting involves a "reality virus" that transforms humans into Funny Animals at a rate that doubles every year.
- Generator Rex: When someone's (or something's) nanites activate, they almost certainly become mindless killing monsters (called E.V.O.s) that try to attack anything and everything. You can also expect said monsters to be nightmarish and have a good bit of Body Horror thrown in. And the rare E.V.O.s that retain their mind/personality/human appearence are people who you probably don't want to hang around with (except Rex). There are also those that turn into freaks but retain their personality, but they tend to either become victims of Fantastic Racism or also be people you'd rather not be around. And said nanites can mutate anything at any given time. They're omni-present and only the titular character can effectively cure aforementioned E.V.O.s.
- The Bio-mechs in Vor Tech were infected with a technological plague transforming them into creatures much like the Phalanx in the X-Men comicbook titles.
- My Little Pony: Friendship Is Magic: "A Health of Information" introduces Swamp Fever, a rase disease contracted by breathing in the pollen of a certain swamp flower. Its initial symptoms are a bit odd — orange spots all over the victim's body, then coughing up bubbles, then sneezing small lighting bolts — but nothing too worrying as far as this trope goes. Things change when the disease reaches its end stage, at which point branches start growing out of the orange spots and the victim is permanently turned into a tree — the very same kind of tree that grows the flowers whose pollen spreads Swamp Fever.