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Anime & Manga
- Attack on Titan: Used by Armin as evidence that Eren is human regardless of his powers. Normal Titans tried to eat him in his Titan form, so that means they recognize him as being a human.
- In 30 Days of Night, Eben realizes that one of the few things that can kill vampires are other vampires. So he pumps himself up with vampire blood and utilizes his brief period of sanity to take on their leader.
- The Alien series:
- Ripley in Alien³ survived an attack thanks to being infected, and later uses this to her advantage when confronting it later.
- In Alien: Resurrection, she's able to kill Xenomorphs easily due to being a Half-Human Hybrid. There is also an infectee who puts his alien embryo to a good use by hugging a villain and letting the embryo tear through both of them.
- Black Sheep (2007) has mutant carnivorous sheep, and IF you survive an attack, their bite will slowly mutate you into a weresheep. The lead manages to cross a flock of sheep thanks to his infection.
- District 9 has Wikus gain access to all Prawn technology 'thanks' to his mutating into one of them. This comes in handy when Cristopher's son sets a prawn battlemech to Kill All Humans mode.
- Terminator Salvation has an interesting case. Though he is always a cyborg, Marcus was attacked by all Skynet robots when he believed he was "human." But after being outed in the resistance base he manages to infiltrate Skynet central in San Francisco because, thanks to this realization, the machines registered him as "Active".
- It also helps that he'd since taken enough damage to reveal his robotic endoskeleton.
- In K.A. Applegate's Animorphs, the kids end up pretending to be Controllers a couple of times.
- Frank Herbert's Hellstrom's Hive. A secret agent is fed hormones that cause him to smell like the mutated members of the title organization, thus causing them to accept him as one of them. He infiltrates the Hive and causes a great deal of damage, until the hormones start to wear off and the members start to smell that he's an outsider.
- In the Star Trek novel Resistance, Picard attempts to infiltrate a Borg ship by partially reassimilating into the Collective as Locutus. It doesn't work.
- In Codex Alera, Tavi and Kitai can fool the Vord as long as the queen doesn't notice them and they don't attack any of the Vord. This is because the Vord Queen's form is based on their blood.
Live Action TV
- In episode 5 of Supernatural's sixth season, Dean gets turned by a vampire seeking "pretty boy" recruiters for it's army. He manages to use this to his advantage in infiltrating the nest. This is less Heroic Sacrifice and more What the Hell, Hero?, as afterward Dean realizes that his brother Sam let him get turned just for this purpose.
- Mind you, he had an antidote back at base that he was like eighty percent sure would work so long as Dean didn't bite anyone. Not that he told Dean. Sam is kind of a dick without his soul.
- Star Trek: Voyager: The Voyager crewmembers try to infiltrate a Borg cube by trying a standard attack and getting assimilated, which turned out to be what they originally wanted. In the series finale, Admiral Janeway intentionally lets herself be assimilated in order to spread a Borg-destroying pathogen throughout the Hub.
- In Angel the titular character used his condition as a vampire to infiltrate the Scourge. The Scourge at first despised him due to his human origin, but he convinced them that he loathed that aspect of himself and wished nothing more than to see humanity wiped out.
- Also comes up in the final season, in Angel's plan to infiltrate the inner circle of evil's operations on Earth.
- The Adversary in Forgotten Realms is a figure of dread in illithid myth. The legend holds that a larva that undergoes ceremorphosis will take on all of the host's personality and memory. This "Adversary" would still be the host, but with all the powers of an illithid. Illithids that inherited little quirks from their hosts hide them so they are not mistaken by their peers for being the Adversary. The Adversary is no mere myth. A scholar found a way to interfere with ceremorphosis and retained his mind and soul despite becoming an illithid. He acts as a mole within illithid society, doing what he can to be as subversive as possible. Such as spreading the legend of the "Adversary".
- In World of Warcraft, the isolationist nation of Gilneas is turned into Worgen (werewolves) by a mysterious curse. Later on, they're attacked by the undead Forsaken (eventually the greater Horde in general), causing them to join the Alliance. Eventually, the Forsaken gain the ability to raise their own undead (previously they were only able to gather undead that were already raised by the Lich King), including the soldiers of the Alliance sent to fight them. The Worgen, being immune to the Plague of Undeath due to their curse, repaid the Alliance's efforts to save their people by taking the fight to the Forsaken.
- In The Walking Dead game, Lee breaks through a mob of zombies to save Clementine. The walkers barely notice him due to his infection, and being covered in zombie blood.
- In Star Trek: Borg, the player character, currently possessing the body of a Bijani crewmmate, intentionally goes into a Bijani pain trance so that way when the Borg transforms him into one of their own he manages to retain his own mind, which in turn allows him to his his enhancements and links to the collective against them.
- In Gabriel Knight 2: The Beast Within, the titular character becomes a werewolf and then- having transformed into a wolf but not killed or eaten a human yet- is able to reverse his curse by killing Von Glower, the source of the curse.