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Anime and Manga
- An interesting variation occurs in the Rurouni Kenshin: Seishohen OVA, where Kenshin and later Kaoru suffer from an unknown disease. Fans either call it "Super Tuberculosis" or speculate that it may be syphilis based on the symptoms, but it's likely either a specific unmentionable or one they just made up. In either case what exactly it is never gets brought up, but seeing as it's set in late 1800s Japan this may be justified by the setting.
- 13th squad captain Jushiro Ukitake from Bleach has a never-named illness that may have cause his hair to lose its color (his eyebrows are black, the rest is white), leads to him laying in bed sick a lot, and occasionally makes him cough up blood. A Fan Nickname of his is "Captain Tuberculosis."
- Tubercolosis, incidentally, is not known to dye your hair in Real Life.
- In an SBS of One Piece, Oda Eiichiro was asked if a disease he had mentioned in the series was real. He noted that, yes, it definitely is real, but the name and general idea was tweaked a bit to sound fictional. Apparently, in the manga business, some terms/diseases are frowned upon for being "too real."
- Hyatt from Excel Saga suffers from some unknown disease that causes her to vomit blood and die on a regular basis. She always gets better, though.
- The "Mars Rays disease" from Mobile Suit Gundam AGE, which is terminal and can strike anyone living on Mars, is basically cancer. In the show, it's supposedly caused by "rays" from Mars's magnetic field, but in Real Life Mars lacks a magnetic field. That leaves it exposed to a hell of a lot of radiation.
- Inverted in Ill Boy, Ill Girl. The disease that have afflicted the eponymous duo does not have a name. It's a plot point, though, as the boy has dibs on naming the disease after him... provided he dies from it first.
- In Naruto, Itachi dies of a disease that causes fits of coughing and Blood from the Mouth, that he was receiving treatment for. Most fans think it was tuberculosis or something along those lines, but the disease itself is never actually named.
- In the Filler arc, Kimimaro dies of a very similar disease, which may or may not be the same thing.
- In My Neighbor Totoro, Mrs. Kusakabi is hospitalized, though what for is never stated outright. It is thought to be tuberculosis.
- In Fushigi Yuugi: Genbu Kaiden, Mrs. Okuda is suffering from tuberculosis at the beginning of the story, though it is usually referred to as "consumption" instead of by its proper name. She and Takiko's governess wish to keep the illness a secret, because the social stigma might jeopardize 17-year-old Takiko's ability to get married. (Takiko's classmates seem to know that the Okuda family moved to Morioka from Tokyo because of an illness, though they don't know all the details, and gossip constantly about it.)
- Jack Chick's tract "Wounded Children" contains an odd variant: A Depraved Homosexual speaks of his lover dying of "cancer", which a footnote tells us means "AIDS".
- Jerkass Has a Point: It wasn't unusual in the 80's and 90's for people with AIDS to say they had cancer, to avoid the stigma. In many cases, it's not a total lie, since Kaposi's Sarcoma is an opportunistic skin cancer (the infamous black lesions) AIDS victims often die from.
- There's an autobiography (in graphic novel form) called Stitches, about this guy's crapsack childhood. At one point his parents don't tell him that he has and is about to undergo surgery for throat cancer. He finds out by accident a while later, and when he asks why he wasn't told they tell him it's because he "didn't need to know."
- Played with in Through Thick and Thin with Ryuuko's illness. Invoked, as Satsuki, in her narration, prefers not to refer to it by name and neither does everyone, however, from all implications, the former is being treated for cancer.
- In the Frozen fanfic Darkness Burning after an Interrupted Suicide attempt Elsa is described as "ill" instead of specifying she suffers from depression. This causes people outside her family to speculate exactly what the illness is. Elsa herself refers to her depression as being a "darkness".
Films — Live-Action
- Cries and Whispers: Agnes' terminal disease that gets her killed halfway through the film. The disease's name is never stated outright, but is strongly implied to be uterine cancer because of her pained writhing and how the doctor examines her.
- An amazing example in 1939 Tear Jerker Dark Victory, which uses words like "glioma", "growth", and "malignant", and kills off the Ill Girl at the end, but never says "cancer" or "brain cancer".
- Even pregnancy can fall to this. In one of the Benji movies, Tiffany (the dog) was referred to as being "ill" when they meant "about to have puppies".
- In Moulin Rouge!, Satine has consumption (tuberculosis), but this is kept from her until near the end of the movie when she dies from it onstage.
- At the end of Forrest Gump, Jenny tells Forrest that she's "sick". It's never said what she had, only that it's a virus and was terminal. Given the disapproving tone surrounding Jenny's Bohemian lifestyle outside of Forrest's orbit, and that Jenny could be seen as experiencing the "bad side" of decades versus Forrest's hopeful one, it was often assumed the 1980s setting meant it would be AIDS. An especially sad case as Jenny was still incredibly unsure of herself when she left Forrest the second time, before Forrest Jr. was born, and a relapse occurred during their life apart. Also leads to some complaints that verge on Reality Is Unrealistic since the fact that neither Forrest nor their son seem to be infected can happen if an infected person is careful, and straight men are at low (not zero) risk of infection through sex. The worst part is that Jenny exhibits no symptoms of her disease while dying other than feeling very, very tired...making her appear to be the physically weakest human being in history.
- In MirrorMask, it's never said outright what is afflicting Helena's mother, but the implication is pretty clear that it's a brain tumor (it's also stated explicitly in the companion book).
- Secrets & Lies: The cause of Monica's infertility is never mentioned, although some have speculated that it might have been endometriosis.
- In And the Band Played On, about the first decade of the AIDS epidemic, this is a plot point. When Richard Gere's character, a No Celebrities Were Harmed version of Michael Bennett, dies, his obituary reads that he died after a "long illness," leading Dr. Don Francis, the protagonist, to object that "This could be the first deadly epidemic in history of which nobody officially died."
- Trainspotting: Tommy has "the virus" but never knew he'd gone "full-blown". He officially died of toxoplasmosis, an opportunistic infection that attacks immuno-compromised people. Renton had to get tested for something that he may have also contracted, but fortunately for him his test came up negative. Clearly his disease was AIDS but it's never used in direct reference to him. The HIV virus is brought up during Renton's Going Cold Turkey nightmare, but at no point in the film is it stated directly that Tommy has, or that Renton doesn't have AIDS.
- Though the phrase "AIDS Junkie" spray painted on Tommy's door might have been a clue.
- In the '90s Australian film The Sum Of Us, Jack Thompson's character is struck down by a stroke. Contemplating this in the hospital, he recalls that when his son came out as gay, he thought he might some day have to watch him dying in hospital of "that terrible disease" (meaning AIDS).
- In Tear Jerker One Way Passage, poor Joan is dying of...something. Something that leaves her looking beautiful, and perfectly healthy, except for the occasional fainting spell. A throwaway reference to a sanitarium vaguely implies TB, but she never coughs.
- In the opening scene of State of the Union, where Kay meets her dying father, he talks about something "eatin' my guts away", and he says a little bit later that he can't stand the pain anymore. The word "cancer" is not mentioned.
- My Cousin Rachel: Ambrose's father died of a tumor in the brain, and Rachel and Guido attribute both Ambrose's death and the terrifying letters he sent to Phillip to a tumor in his brain that affected his mental state. The word "cancer" is not used.
- Played with in Brighton Beach Memoirs when the main character points out that any kind of illness is whispered. At one point he tells a younger sibling to tell his mother he has diarrhea and whispers the last word.
- No one wants to talk about AIDS in Tell the Wolves I'm Home, although justified due to it being set in The '80s.
- The following lines about being gassed from Wilfred Owen's WWI poem Dulce et decorum est were edited by many when first published, often just by removing the word cancer and leaving the poem with a ruined meter.
Come gargling from the froth-corrupted lungs,
Obscene as cancer, bitter as the cud
- A 19th century French story where (mentioned in passing) an Englishwoman goes and deliberately gets infected so as to sleep with Napoleon and give him the disease. (It doesn't work.) The disease part is very quickly glossed over, but it's pretty obvious what it is they're talking about.
- Mildred in Of Human Bondage is strongly implied to be a prostitute and dies, almost certainly of syphilis.
- Digory's mother in The Magician's Nephew, until she is cured by a magic fruit. In Real Life, author C.S. Lewis' mother died of cancer when he was ten years old.
- Dragon Queen: whatever Trava's father has.
- The Pearl Diver, by Jeff Talarigo, is a very thoughtful and in-depth discussion about how leprosy (and later AIDS) was this in Japan for ages. You didn't talk about it. If your family member caught leprosy, they got sent off to a different island, and were stricken from the record as if they'd died.
- At one point in The Tragedy of Y (by Ellery Queen), the York family doctor lets amateur detective Drury Lane read the family medical history, specifically all the parts that talk about the positive Wasserman tests. The book never uses the word "syphilis". Not even when Lane gets access to those medical files by proving to the doctor that he already knew the York children had been born with the disease.
- Discussed in Two Weeks with the Queen. Colin reflects on the fact that he's never heard anyone other than a doctor refer to his brother's condition as "cancer". When he meets Ted, he first warms to him when Ted openly refers to the disease by name, rather than shying away from it.
- In the second Flashman book, Royal Flash, a character is described as suffering from a "social disease." To which Flashman immediately responds, "You mean he's got the clap?"
- Tiny Tim's disease, to modern readers.
- Researchers say it was most likely a kidney problem or rickets.
- O-Lan in Pearl S. Buck's The Good Earth became sick later in the book. Her illness was never named, but she described it as "a fire in my vitals," which sounds like cancer.
- In the Trixie Belden series, Honey's governess, Miss Trask, had an ill sister. Miss Trask looked after her in the hospital when she was chaperoning the B.W.G.s and their friends in New York in Mystery of the Blinking Eye. They never mentioned what the sister had, though.
- Skorpan in The Brothers Lionheart. He died of tuberculosis but the disease is never named in the book.
- Subverted in L. M. Montgomery's novel Magic For Marigold, in a chapter called simply "It." "It" is a mysterious disease that the adults around Marigold suspect she has caught, but which no one will tell her what it actually is, driving the girl distracted with all sorts of horrible imaginings of what "It" might be. Until her aunt tells her that "It" is simply head lice.
- In A Song of Ice and Fire, there is a lot of characters who have vaguely described medical conditions. This is a medieval world where the local doctors just do not have the knowledge to identify diseases as we do, so all we have is symptoms. Nevertheless, the disease from which Lord Hoster Tully is dying is heavily hinted to be cancer.
- In a Monty Python's Flying Circus animation sequence, we have an enchanted prince who gets a spot on his face, ignores it and dies of cancer, but the word "gangrene" was very obviously dubbed over "cancer" in a very different (as in, male as opposed to female) voice. It can be heard as intended in And Now for Something Completely Different.
- Good Times was the first time STD (then called VD) was mentioned in a (US) fiction TV show, but they never really said what it was or how it was spread, just that JJ's ex had VD and he should get tested, along with Anvilicious speeches about VD (given the time frame, they almost certainly meant gonorrhea).
- During the final season, Willona wants to protect little Penny from the facts of life, suggesting to her adopted daughter that her 12-year-old pregnant friend had simply contracted the "Stomach Mumps." Terms related to teen pregnancy are freely exchanged between Wilnona and Florida, as the two bitterly argue about whether to tell Penny the truth (Willona is forced to when Penny is nearly sexually assaulted in the hallway).
- Another STD example on Dr. Quinn, Medicine Woman, paired with Getting Crap Past the Radar, seeing as how this was a family show airing at 8PM. In the series first episode, prostitute Myra comes to see Dr. Mike about a "female problem". Later, Dr. Mike tells Hank, owner of the local brothel, that Myra needs to be "chaste" for several weeks. When he complains about the loss of revenue, she warns him that he'll lose a lot more if she has to treat his customers as well. In a later episode, Hank asks why Dr. Mike has been oblivious to the fact that her sister Marjorie is ill—"That husband of hers left her with more that anyone suspects". Mike realizes what the problem is and gently tells her sister, "It's not your fault, he gave it to you", then offers to give her an injection of silver nitrate in order to clear up the infection. Given the treatment mentioned, it's obvious that Marjorie's unfaithful husband has given her gonorrhea.
- The Hogan Family: The first use of the word "condom" and what it's for on a (US) fiction TV show was in a Very Special Episode during the series' second season (episode titled "Bad Timing," when Valerie told David to use a condom if he had sex with his girlfriend. The episode aired with a content warning.
- Unlike many other sitcoms, The Hogan Family also unashamedly addressed AIDS in one of the last episodes of the series, where David's best buddy Rich contracts AIDS. The episode shared Rich's last days and ends with his death.
- On Happy Days when Chachi asked for Mrs. Cunningham's blessing for he and Joanie to get married he said he "had to" marry her, so Mrs. C thought he and Joanie were "in trouble" — that he had knocked her up. But no, he "had to" because he loved her so much.
- Non-disease example: on Sex and the City, Charlotte mentions that her Jewish boyfriend has relatives who died in the Holocaust, a word she says at least 20 decibels lower than the rest of the sentence. She may have also done the same about Samantha's cancer.
- After Scott dumps Buffy Faith sees him with another girl. She gets a brainwave, goes up to him and claims the sexually transmitted diseases she got from him were clearing up, getting some measure of revenge for what he did to Buffy.
- A season 4 episode of The Golden Girls has Sophia volunteering at the hospital. One of her favorite people to visit with is a young boy who is a patient. She encourages him by telling him, "One day, they'll find a cure." Considering that it's 1988, it could have been AIDS, or it could have been cancer, with a comment about his blood getting messed up by a bad transfusion heavily implies the former (the story took place right at the same time as the Ryan White story.)
- There was a sketch in The Kids in the Hall where Scott Thompson played a celebrity who denied rumors that he was gay. The narrator claims that he kept denying the rumors up until the day he died of AIDS. The camera shows his body at the funeral and his corpse says out of the side of his mouth, "It was cancer."
- Only Fools and Horses: In "Sickness and Wealth," Del is worried that he might be suffering from a certain disease, and subsequent dialogue makes it obvious that he's talking about AIDS. The disease was still pretty taboo in 1989, hence why it isn't mentioned by name, but the episode shows quite a surprising degree of AIDS awareness, most notably the fact that it isn't—as was widely considered to be the case at the time—something that only gay men contract.
- Babylon 5 included an in-universe example with the disease which ultimately wiped out the Markab. Sufferers would not discuss it or seek treatment because most Markab believed the disease only struck the immoral and impure. At one point, Dr. Franklin lampshaded the fact that this resembled human behavior surrounding many plagues, including AIDS and the Black Plague.
- On Revolution episode Captain Trips, Rachel is listing off diseases that the patients have other than the manufactured one they're all suffering from, and in a real sign of what's accepted in modern society versus what's still not, she says in a normal voice that two of them have Bipolar and Epilepsy, but whispers when she says that the third woman is an Alcoholic.
- Prince used "A big disease with a little name" to describe HIV/AIDS in Sign o' The Times.
- Amateur Transplants hilariously parody the practice in their Dorsal Horn Concerto song.
- TLC's song "Waterfalls" features this. It's a series of morality plays, and the second one is about a man who sleeps around, and it gives us this gem:
His health is fading and he doesn't know whyThree lettersnote took him to his final resting place
- The American folk song "St. James Infirmary", and its British progenitor, "The Unfortunate Rake", never mention the illness that dooms the narrator and his sweetheart, but details in the lyrics provide a clue: mentions of "white salts" or "mercury pills" mean mercuric chloride, a 19th century remedy for syphilis.
- The real St. James Infirmary was a medieval leper hospital, and the song probably dates back that far (after 1536 the building was generally known as "St. James's Palace"). This may be an example of one Disease That Shall Not Be Named substituting for an earlier one that had faded from memory.note
- R. Kelly's "Trapped in the Closet" has characters mention a disease called "The Package". Averted in later chapters, people ask if "The Package" is AIDS/HIV.
- In Meet the Feebles, the doctor ominously tells Harry he's caught "The Big One". This trope is averted when we find out near the end of the movie that he meant myxomatosis.
- Though, for a rabbit, myxomatosis is a Big One indeed.
- In Cat on a Hot Tin Roof, the doctors never tell Big Daddy or his wife that he has cancer, telling them instead that he has a spastic colon.
- Henrik Ibsen's Ghosts was incredibly controversial in its time merely for referring to congenital syphilis, even though the disease was never named outright.
- Angels in America uses the aforementioned Roy Cohn inversion. Prior occasionally plays the trope straight by saying that he's "sick" and "diseased". While he is able to admit to his boyfriend what he has, he does fuss around before spitting it out.
- In Neil Simon's Brighton Beach Memoirs, the mother mentioned that someone had tuberculosis, but said in in a quiet, hushed tone.
- In Passion by Stephen Sondheim and James Lapine, nobody, not even the doctor, explains what Fosca's disease is.
- In Dead End, Martin's ex-girlfriend Francey reveals she is "sick" when he tries to kiss her on the mouth. It is only hinted at that she was forced into prostitution and dying from syphilis. (The play does describe her as "an obvious whore of the lowest class"; for obvious reasons, this doesn't come across so clearly in the movie.)
- In La Traviata, Violetta's tuberculosis is only mentioned by name once, in the last act, while in La Bohème, Mimí's TB is never mentioned by name at all. In both cases, the audience is supposed to recognize the disease just from the symptoms, and possibly from familiarity with the sources, La dame aux camélias and Scenes de la vie de bohéme.
- In the Arthur episode "Grandpa Dave's Memory Album," it is shown that Arthur's grandfather is suffering from memory loss, but no disease (such as Alzheimer's, dementia or brain cancer) is mentioned.
- When Terry Pratchett gave the 2010 Dimbleby Lecture, he mentioned that Richard Dimbleby (after whom the lectures are named) broke a taboo by admitting he was dying of cancer (almost invoking this trope by name). He went on to say that Alzheimer's and Dementia is now in the same category.
- When doctors diagnose a person with scabies, it is named with the technical name of scabiosis. Rather obvious in English, but not so in other languages (Spanish "sarna" vs. "escabiosis").
- Doctors in general like to tell the patients their diagnoses as indecipherable Techno Babble if these diagnoses are terrifying enough to endanger the patients' mental health as well. For example, schizophrenia may be referred to as "SCH" (works particularly well in languages with non-Latin scripts, so the patient cannot make the connection).
- Isaac Asimov contracted HIV when he was transfused with infected blood during heart surgery, but the stigma associated with the disease caused him to hide the condition throughout the rest of his life. When he died from AIDS-related complications, his cause of death was publicly given as kidney failure, and it wasn't until ten years later that his family revealed the truth in a biography. According to his wife Janet, Asimov wanted to go public during his lifetime but was persuaded not to by his doctors for the sake of his family and friends, as it was quite likely they would suffer from anti-AIDS prejudice that was prevalent at the time.
- Most newspaper obituaries will read that a person died "after a long illness," which usually means one of these.
- Speaking of newspapers, many horoscope columns now use the term "Moon Children" for those born from late June to late July, instead of Cancer. Aside from invoking this trope, it is even more ludicrous when you realize the disease was named after the crab (Latin name: cancer), because an untreated breast cancer can look like a crab.
- As mentioned above, head lice. Although it's not a sign of dirtiness or being low class, the sheer amount of work involved in eradicating the live lice from one's head and home (usually 2-7 days, and most of your day will be taken up with it), and removing the dead nits from the hair (at least two weeks), makes parents cringe when they hear somebody in their child's class has it. And most schools will not reveal who patient zero is, but simply send home the lice letter to everybody in the school, to avoid ostracizing the child.
Exceptions and Aversions
Anime and Manga
- In Black Jack's back story, he broke this taboo to straightforwardly tell a fellow medical student she had ovarian cancer. Overall, Black Jack tends to be very blunt about the patient's chances.
- Averted in Tokyo Godfathers when Hana's foster mother hears that Hana lost her boyfriend and asks (albeit under her breath) if he died of AIDS. Hana clarifies that he slipped on the soap in the shower.
- In Kill la Kill AU, Room 002108, we have this with Ryuuko's illness, then again, she was mentioned be hospitalized for tests, in which case, this may be justified in that what she has is unknown (to both the reader and anyone that isn't hospital staff). However, it is subverted when Nonon (called Nonie) tries avoid saying the taboo word which is, true to the trope, cancer and that, when she said it, it was treated as though she had said a swear or uttering it could be Tempting Fate, but mentions that may be what Ryuuko has and as to why she was hospitalized "for tests". Earlier, this was also averted when it was stated Satsuki was severely ill with tuberculosis.
- Averted in Sunshine with Satsuki's illness being leukemia, the which she dies from.
- Also averted with Endless Numbered Days and Satsuki being ill with lung cancer, which later on progresses to terminal.
- Olivia Benson in this  is mentioned to be diagnosed with cancer, the which she passes away of three months later.
- In Odds and Probabilities, a prequel to Through Thick and Thin (see above), Ryuuko's illness was diagnosed to be Non-Hodgkin's Lymphoma.
Films — Live-Action
- Averted in The Shootist, where John Wayne's character is explicitly said to have cancer.
- This may have something to do with the fact that John Wayne himself had previously struggled with lung cancer and done several PSAs about the disease. He would be diagnosed with stomach cancer shortly after the movie's release; this would be his last film.
- Played straight to a degree. It is never explicitly stated that Books has prostate cancer.
- From Team America: World Police, "Everyone has AIDS!!" (Which is a parody of RENT, discussed in the Theatre folder below.)
- Oddly inverted, along with just about everything else, in The Room. Lisa's mother says off-handedly that "I got the results of the test back. I definitely have breast cancer." Setting it up as a possible plot point. However, it is never mentioned again, and Lisa herself doesn't seem particularly affected by the news.
- Averted in Forrest Gump for Mama Gump, if not for Jenny. Forrest says outright that "she had got the cancer, and died on a Tuesday."
- A female character in the Anthony Trollope novel Doctor Thorne has been diagnosed with breast cancer. The condition is treated matter-of-factly, as it would have been in Trollope's time in Real Life. However, the idea that cancer was not shameful was so shocking to early 20th century readers that some believed Trollope instead meant to show the patient as a pathetic malingerer who claimed to have cancer so she could get the doctor to feel her breasts.
- Rebecca was revealed to be dying of a tumor in her ovaries, which mean that she couldn't have children.
- Deliberately averted by Norman Spinrad in "Carcinoma Angels". The original publication in Dangerous Visions was introduced with "This is a very funny story about cancer", and the writer's end note deliberately kept saying "cancer" in the course of railing against this trope.
- Played with in-universe in the John Putnam Thatcher novel Brewing Up a Storm. One of the suspects says he has an alibi, but refuses to tell the cops what it is. He went out of town to get an HIV test, after learning a woman he'd dated had turned up positive. At the end of the novel, another character points out that the woman in question had been blabbing the news all over town for months to get sympathy.
- Subverted in the short story "Roman Fever" by Edith Wharton. Mrs. Ansley and Mrs. Slade reminisce about their youth, when high class girls like them were discouraged from going out after dark in Rome, as it would cause them to catch "Roman Fever," a debilitating illness that would leave them bed-ridden for months. Neither specifically says what it is, but the narrative hints that it might be Malaria. It's really a euphemism to hide pregnancies. When a young girl goes out with her beau after dark and gets pregnant, the family uses the socially acceptable excuse, "Oh, she caught Roman fever" in order to hide her from society until the baby is born.
- In Rubyfruit Jungle Molly's adopted mother Carrie bluntly points out that her husband Carl contracted syphilis while sleeping around behind her back.
Live Action TV
- Spoofed when Tommy of Rescue Me confesses to a fellow firefighter he thinks he caught the "big C" from a woman. He's quickly corrected that chlamydia is the "little c".
- Call the Midwife: Defied. When Chummy's mother is in her final illness, she mentions that people often refuse to mention its name. She more or less says that's for people with no backbone, says she has cancer, and says, "The beast is named."
- Funky Winkerbean has had several plots and events based around characters dying from cancer and never held back about what it was.
- Refreshingly averted in the South African Sesame Street, which features Kami, an HIV positive Muppet.
- Averted in RENT, where characters that have AIDS are pretty frank about it. In the film version, however, Roger and Mimi recognize each other's affliction through the medication without mentioning the name of the disease — though it's still averted in the case of Angel and Collins, who speak about it frankly and by name.
- Eugene Brieux's problem play Damaged Goods, though now forgotten, caused quite a stir in its time by referring to syphilis by name.
- Averted in South Park when Scott tells Terrence and Phillip that he hopes they both get cancer with special emphasis on "Can-saa!"
- AIDS especially is often joked about. With the episode "Jared Has Aides", it was noted that only South Park could do an episode that consists almost entirely of an AIDS pun and end up getting in trouble for something else.
- And then there's the episode where Cartman got AIDS:
Cartman: We're not just sure, we're HIV positive!
- The 1990 Peanuts special Why, Charlie Brown, Why? is about Linus befriending and helping a girl with leukemia. This made Peanuts be the first animated series to ever directly talk about cancer.
- As mentioned above Arthur played this trope straight once but they've also averted it, when one of the major side characters was diagnosed with cancer.
- Played with in an episode of American Dad!:
Neighbor: Well, my wife died. The Big C.
Neighbor: No, the big C from the Costco sign. Fell right on her.
- Bob's Burgers — Bob tells Tina to keep quiet about an insurance scam, pointing out that Linda (his wife) can't keep a secret — cut to the two of them entering a cocktail party and Linda cheerfully shouting "Hi, sorry we're late, Bob had diarrhea!"
- In the 1960s, John Wayne went public with the fact that he'd had lung cancer — and through surgery had "licked the Big C". He remained in remission for several years before developing stomach cancer; he died in 1979.