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Anime and Manga
- The Grand Panacea from Baccano!. Its perfect form also grants immunity to aging.
- Chopper's dream in One Piece is to become a living Panacea, capable of curing any illness.
- Invoked in Jin, when the pre-Meiji era doctors at Medical Institue think that penicillin is a panacea. As we know today, it's not.
- In JoJo's Bizarre Adventure, Antonio Trussardi's stand Pearl Jam turns any food he makes into this. Eating his food makes you heal in some unfortunate ways, like throwing up your intestines.
- Subverted in the first Squadron Supreme miniseries. Science Hero Tom Thumb knows that a "panacea potion" exists in the future one of the team's foes comes from, so when a person important to him gets a fatal illness, he goes there to obtain it. Turns out that in the future, people are so healthy that they only need penicillin and a few vitamin supplements to beat any illness...
- In Creature Tech, the staff at RTI realize they're dealing with the real Shroud of Turin when they realize the blood on the shroud can heal any wound and raise the dead.
Films — Animated
- Rapunzel's hair in Tangled, as well as the flower that she got her magic from.
Films — Live-Action
- The father in My Big Fat Greek Wedding pulls out Windex anytime someone has an ailment, and in the film, it seems to cure everything from poison ivy to pimples.
- The Radix: The eponymous MacGuffin is an ancient plant that, if cooked properly, can heal any illness and even raise the dead. Supposedly, it belonged to Jesus himself. Stored in a mummy's chest for ages, it made its dead tissues regenerate and bleed.
- In the first (plotwise) book in The Chronicles of Narnia: The Magician's Nephew, the apples of a particular tree in a special garden have the power to cure disease. The scenario was written to reference the garden of Eden, and the fruit enfolded a Secret Test of Character: after taking one, Diggory is told that had he eaten it himself, or stolen it for his terminally sick mother, he'd have ultimately regretted it; it doesn't just cure disease, it makes one unable to die even if one wants to - they have given up any possibility of Heaven in favor of unending life on Earth. The White Witch did exactly that, and it took Aslan's personal touch to end her. But because he resisted temptation, he is given an apple from the tree which grew from the one he retrieved, which fully restores his mother and permits her to die peacefully decades later.
- The Athelas weed, aka Kingsfoil, in The Lord of the Rings has unspecified medicinal properties; it may not be good for everything, but it is able to cure several ailments, most notably the Black Breath, a curse brought on by contact with the corruption of Sauron. The process of preparing the remedy suggests that magic is involved. The same plant is used in The Silmarillion.
- In the Belgariad, Garion makes one of these by accident. When asked to make a rosebush bloom with sorcery for his cousin, he refuses because it'd hurt the plant but compromises by creating a new flower from some twigs. This seems to be the end of the matter until well into the Malloreon, when it turns out to be the "sovereign specific", capable of curing any poison, even one previously believed to have no antidote and resist magic curing. Its further medicinal properties are explored by Polgara but never specified on the page.
- Similarly, in The Elenium by the same author, The High Queen has been administered a poison believed to have no remedy, and her champion must find an object of power to cure her. As it happens, none will suffice but the Bhelliom, a Cosmic Keystone of practically unlimited power. Although the story initially serves up the Bhelliom as a cure to this specific predicament, it quickly becomes a greater MacGuffin by dint of the desire of the Big Bad to possess it by any means.
- Harry Potter
- A bezoar is a stone taken from the stomach of a goat, and it can resolve most, though not all, poisons. Despite the seeming mundanity of the origin, bezoars seem to be quite rare, as they are mentioned to be expensive, and the school's potion ingredients store contains only a few.
- As well, phoenix tears, in addition to mending flesh, are strong enough to be the only cure for basilisk venom.
- Drinking unicorn blood can sustain one's life no matter how serious the affliction, but the drinker is cursed thereafter because of how evil it is to hurt a unicorn.
- Mandrakes can be used to brew a potion that will dispel any curse, and even cured an affliction that merely looked like a curse. However, not just any mandrake, only a specific, extra deadly, stubborn variety will do.
- The Hogwarts hospital wing also has a drug that will clear up a wide variety of common illnesses, at the cost of causing smoke and steam to continually come out from the patient's orifices.
- On Gor the Caste of Physicians have created a pretty good panacea in the "Stabilization Serums," a series of shots which effectively make you immortal and stop aging. You can still die due to injuries of course, and it doesn't work 100% of the time; more like 98%. In book 27 there's a newer version which de-ages you 10 years per treatment. And the Priest-Kings — the Insectoid Aliens Powers That Be of Gor — have perfected them even more: Misk the Priest-King is over 6,000,000 years old. The physicians have also cured almost all diseases except "the Holy Disease" which is believed to be a punishment by the Priest-Kings.
- Lansip fruits in Tales of Kolmar can cure just about anything, and can even reverse aging. However, they're extremely hard to come by, as lansip only grows on an island that is protected by strong storms - ships can only get through about once every hundred years.
- Codex Alera has the mushroom called the Blessing of Night, which grows in only one place and can heal injuries, poisoning and also infertility.
- Kate Daniels has panacea be a miracle drug that helps shapeshifters to not go full loup. It's incredibly hard to get a hold of. Until Kate rescues a guy who knows how to make it and brings him home with her, anyway.
- In The Andromeda Strain, when a rubber seal fails and one of the main characters is exposed to the virus, he volunteers to take Kalocin, a top-secret antibiotic that destroys all unicellular life — bacteria, fungi, viruses, you name it — and even causes remission in cancer. One of the other scientists absolutely refuses to allow it. An expository paragraph then explains that when tested on humans, the drug wiped out all the symbiotic microorganisms living inside and on them; when the doses stopped, harmful microbes moved into the now-empty biological niches and killed all the subjects in various grotesque ways within six hours.
- Among its many other functions, the titular energy of The Stormlight Archive can heal just about anything, including cuts, broken bones, bad eyes, missing limbs, damaged souls, and, under the exact right circumstances, death itself. It is as yet unclear whether it will stop aging.
- Worm has a character named Panacea who is capable of healing any injury or disease. Just make sure not to get on her bad side - she's capable of healing such "ailments" as non-obesity, virility, lack of allergic reaction to air... Just ask Glory Girl.
Mythology and Religion
- Some versions of the Holy Grail myth had it that the Grail could cure anything, grant immortality, etc. This idea was relished by treasure-seekers for whom a relic of unrivaled holiness just wasn't good enough. The same kind of powers have been attributed to any number of other Christian relics.
- Dungeons & Dragons has the Philosopher's Stone item, which can be broken open and used to make a potion which can heal anything up to and including death.
- Pathfinder also has this item. In addition the Alchemist class can (at high levels, and if they take the relevant skill) make one.
- The 3rd Edition supplement Creature Collection: The ewe of the Amalthean Ram gives milk that neutralizes non-magical poisons and diseases in anyone who drinks it.
- There is also Keoghtum's Ointment which can cure various things.
- Warhammer 40,000's background lore features an STC, Standard Template Construct, known as the Panacea which would have led to medical breakthroughs that would save billions of Imperial citizens across the galaxy... if the Dark Eldar Kabal of the Poisoned Tongue hadn't stolen it because Asdrubael Vect dared Lady Aurelia Malys to do it.
- General: The panacea is one of the Standard RPG Items, and comes in a few flavours. The weakest and most common is a standard "antidote" item that cures Universal Poison. The rarest is a "cure" item that works against a specific "disease" condition. "Panacea" is commonly used as the name of an item that removes all Standard Status Effects.
- In Tales of Vesperia Yuri, Karol, and Estelle try to use a panacea bottle to heal the big cherry blossom tree in Halure and, from then on, it becomes a regular item that cures both physical and magical ailments.
- Panacea is a summonable item in Scribblenauts (along with everything else). In the sequel it heals any sick or diseased creature, and renders an already healthy one invincible.
- The goal of one subplot in Ōkamiden is to make a perfect medicine in order to cure a terminally ill girl.
- In Cave Story, you retrieve a "cure-all" pill from the abandoned hospital in the labyrinth. The full curative abilities of this medicine are unknown, but it heals Curly Brace (who is a robot) from unspecified debilitating injuries.
- The Elder Scrolls V: Skyrim has disease-curing potions that are easy to make or buy, raw ingredients such as hawk feathers and charred rat skin that cure diseases on their own, and if that's too much bother, praying at a local shrine will have the same effect, plus a deity-specific blessing. Curing vampirism and lycanthropy is a different story, however.
- Bloodborne is themed around disease and blood, set in a Mystical Plague infested city that uses Blood Magic. The player character has some sort of disease, and came to Yharnam seeking a substance called "Paleblood" that can cure any ailment.
- SCP Foundation has SCP-500, pills that cure any disease, but there's just about fifty of them and they're impossible to replicate perfectly (though knockoffs can work if you're lucky).
- Later, SCP-427: the Lovecraftian Locket was developed that has eclipsed it in use. It has its own problems like overexposure, though.
- Solstoria has a character who is searching for a panacea for her mom.