The Andromeda Strain is a novel published by Michael Crichton in 1969 about a team of scientists who investigate a deadly organism of extraterrestrial origin that causes rapid, fatal blood clotting. As the novel opens, the microorganism has killed an entire town save for two individuals, an old man and a crying infant. The team races to find the common link between the two survivors before the rapidly mutating organism can find a way out of containment and cause a deadly epidemic. Most of the action takes place in an underground research installation called "Wildfire", located in a remote part of Nevada. A lot of the book and the 1971 movie spend considerable time showing the process the research team has to go through to be decontaminated just to be able to work on the problem.The novel has been adapted into movie form twice; the 1971 film starred Arthur Hill, James Olson, Kate Reid, and David Wayne and followed the book closely, while the 2008 miniseries is a re-imagining of the original story.
This novel contains examples of:
Apocalypse How: More of a Class 0 since the town affected left two survivors, an old man and a baby. It's not entirely clear if other towns were plagued with the same condition.
Body Horror: Andromeda dispatches its victims by near-instant clotting of blood - such that most of Piedmont was "cut down in mid-stride." The team get to see wonderful visages, such as a smiling family gathered around rotting food. The autopsy on the man who opened the probe carrying Andromeda also counts, as they chop him open - and only get clotted blood. It's hinted that a few survived long enough to "go quietly nuts." The identities of this latter group - a diabetic and an old chain-smoking lady - provide an early hint to how Andromeda targets its victims. Both would have been mildly acidotic, from uncontrolled diabetes Type I and COPD respectively, which allowed them to survive long enough to develop dementia. The first two cases commit suicide in Piedmont (and leave ranting notes), and a final case which appears later-a diabetic cop that survived initial infection and then shot up a diner-cements the acidosis theory.
Computer Voice: The computer in the Wildfire secret underground base plays pre-recorded messages spoken by a pleasant female voice. It is revealed that the voice, which one scientist describes as "luscious," is that of a woman in her 60's, turning it into in-universe Fetish Retardant.
This is in-universe Fanservice, as the book points out that the most sexy voice the military could find is used for voice reminder systems on the theory that men will pay more attention to it. It also turns into in-universe Fetish Retardant when the same voice also plainly announces the nuclear countdown. Stone finds this extremely infuriating.
Disability Immunity: the eponymous Strain kills an entire town save a baby and an old man. Turns out that the contagion is actually extremely sensitive to abnormal pH levels. The old man was an alcoholic who drank denatured ethanol from canned stove fuel, resulting in acidosis, and the baby had cried himself into alkalosis due to a combination of infantile colic, hunger and fear.
Gender Flip: Leavitt is male in the novel, female in the film. Interestingly, Hot Scientist is emphatically not invoked in the switch.
Failsafe Failure: Several: first, the control stations allowing the override for the nuclear-sterilization protocol weren't installed in several compartments of the center due to bureaucratic delays, necessitating Hall crawling to the upper level through the central core to find a working shutdown station. Second, the core was equipped with automated guns firing curare-tipped darts to stop any potentially infected escaped lab animals, but the dose was calculated for primates less than 20 kg, and not for the much larger human, thus making this mad scramble possible. Also, a warning bell that's supposed to alert the team when important information comes in on their telex machine is defeated when a scrap of paper accidentally jams itself between the bell and striker, silencing it when it tries to go off, and they miss the warning.
Infodump: Pages of it, as befitting a Crichton novel. Surprisingly, the 1971 film preserved the vast majority.
Inscrutable Aliens: It's speculated that the virus was created by an alien species as a data storage mechanism, but we never find out anything about them, and it's only a hypothesis. The more likely explanation is that it's just an organism that thrives on any sort of energy, especially thermal energy.
Magic Countdown: Averted in that Hall disarms the nuclear self-destruct with more than half a minute to spare. Subverted in that the lowest level of the facility is evacuated of atmospherethirty seconds before detonation to increase the yield of the nuke - the researchers were only seconds from being suffocated.
Self-Destruct Mechanism: The Wildfire facility has a nuclear device beneath it that it set to automatically go off in the event of a breach to prevent any nasty diseases from getting out. Unfortunately, the scientists calculate that the heat and radiation from a nuclear blast would cause the virus to mutate into a potentially much deadlier form. In addition, the book goes into detail about the necessarily psychological profile of the one person who should be entrusted with the "off" key. The people in charge calculated that an unmarried male with no strong family connections would be best able to make the decision to allow the bomb to go off.
Spy Speak: The page quote, as well as the exchange by which the team gets into Wildfire:
Guard: You got the time?
Stone: My watch stopped at 10:46.
Guard: Darn shame.
Stone: Must be the heat.
What Happened to the Mouse?: There's one anomaly in the Piedmont population who committed suicide instead of dying like the rest - a boy who decided to ingest paint thinner and glue to kill himself. It's not known if he was affected by Andromeda, or was driven to despair after seeing his entire family die immediately.