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Anime and Manga
- After surviving the sinking of the St. Anne, Ash's party and Team Rocket end up stuck on an island made up of malfunctioning giant animatronic Pokémon, separated from their Pokémon.
- Another episode during the OI season has Meowth and Pikachu tied together in the middle of Fairchild Island, an island containing giant Rhydon and Pidgeot who attack anyone that comes near.
- An issue of Planetary that's a homage to the Godzilla films has the team exploring an island somewhere in the vicinity of Japan that was home to a variety of giant prehistoric monsters, all of which have supposedly died out. Emphasis on supposedly.
- The Centre from DC: The New Frontier, a Hive Mind of prehistoric beasts.
- Mossflower Odyssey 3 takes place on an island inhabited by giant snakes, deadly natives, and is guarded by a Ghost Ship.
- Jurassic Park is an abandoned dinosaur theme park on a tropical island, inhabited by reanimated dinosaurs.
- King Kong: Skull Island is an island teaming with horrific beasts and dinosaurs, with the titular giant ape reigning as king of them.
- The famous Godzilla film series gives us Monster Island, which as its name suggests, is home to many of the creatures that appear in the films, including the titular King of the Monsters.
- Mysterious Island is about a group of castaways who find an island populated by giant animals like crabs, chickens and bees. They were all the work of Captain Nemo as a solution to world hunger.
- At the end of Deep Rising, the remaining survivors have escaped to a beautiful sunlit island, only to hear a terrifying monster roar. The camera pulls back to reveal the island is host to an erupting volcano and something tearing down trees as it makes a beeline for the beach where the protagonists are. Cut to credits as the hero asks with exasperation, "NOW what?"
- In Jason and the Argonauts, while on the Isle of Bronze, Hercules inadvertently awakens the Living Statue of Talos when he steals from the crypt he was guarding. Though the Argonauts manage to defeat Talos, Hercules' best friend Hylas was killed during the battle.
- Jules Vernes Mystery On Monster Island: It's an island of monsters. Not really. The hero's uncle manufactured them to give his nephew an adventure.
- Played with in Lord of the Flies. Most of the boys think there is a physical beast and by the end of the book start to almost worship it, but there is no "real" beast. The idea of the beast is actually used to represent of humanity's innate evil.
- The Ur-Example is The Odyssey, where Odysseus and his crew dock on an island inhabited by a Cyclops named Polyphemus, who imprisons them in his cave and eats them two by two. They defeat the monster by stabbing his eye out with a stick.
- The title character of Sinbad the Sailor often ends up on one of these during his travels, including one where a Roc bird nests, and another inhabited by a man-eating giant (who's basically an Expy of Polyphemus from The Odyssey and gets defeated in a similar manner).
- The Ultra Series has featured a couple over the years.
- One of the first and best-known episodes of the original Ultraman was "The Lawless Monster Zone", in which the Science Patrol visit an island populated by various giant monsters like the dinosaur-like Red King, the bat-like Chandler, and a giant burrowing reptile called Magular. Another one appeared in their two-parter episode, this time home to relic dinosaur and Ensemble Darkhorse of the franchise Gomora.
- In Ultraman Eighty, the characters find an abandoned island resort where an evil alien monster called Gimyra has hypnotized everyone on the island to drink their blood and turn them into its giant monster minions.
- In one episode of Ultraman Dyna, the team visits an island populated by several monsters they have previously met. It soon turns out that the creatures are clones being used as practice targets for a Mad Scientist-made monster called Neosaurus.
- Ultraman Max homaged the original example in a two-part episode featuring Red King, as well as two new monsters - a giant newt called Salamandon and a gliding reptile called Paragler. It's later revealed that the island is actually a dimension-hopping prison for Red King built by Atlantis, and the other two monsters are its guards.
- Ultra Galaxy Mega Monster Battle kicks it up a notch with Bolis, an entire planet of giant horrors. Naturally, the story is that the main characters are stranded on the world in a botched space expedition and have to survive all the giant monsters (all pulled from previous series) that do nothing but attack anything they see.
- In one episode of Hannah-Barbara's cartoon adaption of of The Godzilla Power Hour, appropriately titled "The Horror of Forgotten Island", the crew of the Calico found themselves on an island surrounded by a force field which imprisoned a mutant cyclops that could turn invisible.
- The Simpsons subverted this in an Imagine Spot. When Lisa is told she's failing gym in one episode, she imagines that it costs her a government position and she's sent to "Monster Island". She's told "It's just a name", but ends up getting chased by monsters anyway.
Lisa: I thought it was just a name!
- Steven Universe's Mask Island was not only the home of the beastly Invisible Gem Monster, but was also the battlefield for Malachite.
- In Popeye the Sailor Meets Sindbad the Sailor, Sindbad lives on a Turtle Island where he keeps many dangerous beasts as pets, such as lions, tigers, snakes, apes, a roc bird and a two-headed giant.
- As a Shout-Out to King Kong, in an episode of Nelvana's Babar animated series titled "Conga the Terrible", the young elephant king and his friends get shipwrecked on an island that's home of a giant Killer Gorilla that dwarfs even the elephants. In a subversion, the gorilla turns out to be quite friendly once they get on his good side.
- There is a Monster Island in The Powerpuff Girls, source of all the Kaiju that attack Townsville from time to time. Turns out they do it for the honor of fighting the Girls.
- In Godzilla: The Series, Monster Island is where the military keeps all monsters that have been captured over the course of the series (barring those that need a Tailor-Made Prison instead).
- Several appeared in Jonny Quest, with the beasts that inhabited them usually the result of a Mad Scientist.
- In the Ducktales episode "Raiders of the Lost Harp", when Scrooge discovers the lost city of Troy and the eponymous harp, the Minotaur statue that was guarding it comes to life and follows Scrooge all the way to Duckberg to get it back.
- Adventure Time: In "Mysterious Island", the island is full of giant version of various animals, most of which are hostile.
- Island Gigantism, as Wikipedia states, is "a biological phenomenon in which the size of animals isolated on an island increases dramatically in comparison to their mainland relatives." Results in things like the Komodo Dragon (probably the closest thing to a Real Life example of this trope), the Elephant Bird (a flightless bird twice the size of an ostrich), and the Giant Tortoise of the Galápagos.