Ex Machina was created by Brian K Vaughan, the Eisner Award-winning brain behind series such as Y: The Last Man and Runaways and drawn by Tony Harris. It depicts the life of civil engineer Mitchell Hundred, who gained the ability to communicate with machines. He used his powers to become the world's first and only Super Hero, "The Great Machine". After using his powers to prevent the fall of the second tower in the 9/11 attacks, Mitchell has since retired from the role and is currently the mayor of New York City. The series contains the events of his term in office, with frequent flashbacks to his superhero days.The series wrapped up with the planned 50 issues in 2010.
Also, midway through the series it's revealed that other universes exist, with technological Eldritch Abominations systematically conquering them. One alternate universe is described as being a place where the Cold War never ended, the "son of Reagan" became president instead of George W. Bush, but American Idol and The Other Wiki still exist. That universe is later revealed to have been subsequently conquered, with an allusion made to the extermination of its native human population.
Asexuality: One interpretation about why Hundred doesn't pursue anyone of either gender.
Blessed with Suck: Mitchell's power manifests itself as being able to command machines, and also to "listen" to them. He can't turn it off. To top it all off, he lives in New York City. Think about it.
Also, sometimes, the machines lie. Which is kind of important when a gun tells you it's not loaded and it is...
He was also given these powers as a means to pave the way for an otherworldly invasion. And it's implied there are parallel universes when he joined their cause.
Empty Shell: Mitchell at the end. He's Lonely at the Top as Vice President, has driven off or otherwise lost everyone who was close to him, committed murder, and the invaders have made it clear they intend to try again.
How Mitchell feels about only diverting one of the 767 on Sept 11.
How Mitchell feels about not being able to save his handler and wife from the effects of the superpower shard.
How Mitchell feels about a lot of things, including his career as a superhero.
Flashback: Mitchell tells the story of his time as mayor as a flashback, so his flashbacks to his time as the Great Machine are flashbacks within flashbacks.
Gorn: Lots of characters both minor and major die horribly gruesome deaths, and the artist is not shy about showing them off.
Government Procedural: Much of Mitchell's day-to-day life is political minutiae, minutiae well executed according to the editors of Law and the Multiverse.
The Handler: An NSA cryptologist is assigned to be Mitchell's handler as his powers are regarded as a national secret. It doesn't work out well. Who knew keeping an alienartifact and source of Mitchell's powers would cause insanity? To be fair, his handler was also adversely affected about the Sept 11 attacks and blames Mitch for not stopping the Pentagon attack.
Only Six Faces: Harris is a talented artist, but he only has so many models. For example, a random junkie in "Fact or Fiction" happens to look exactly like a younger, brown-haired Kremlin.
He uses personally staged photos of real-life models to set up panels. And by real-life models, I mean friends and acquaintances.
Plot Hole: It's revealed that the power nullifiers given by Hundred were fakes all along. That'd be fine, except in the first story arc it's shown that Kremlin reversed engineered his nullifier to be make a hidden mic that Hundred couldn't detect, and Kremlin's device worked perfectly. Of course, it's also possible that the device was lying to Mitchell much like the loaded shotgun did.
Reality Ensues: While she's walking from her gym, The Great Machine grabs the commissioner of Police and takes her to a rooftop to talk. She reaches inside the bag and he says he could make her gun jam. Then she pulls out a baton. He has enough time for an Oh Crap before she hits him in the head.
Shout-Out: Mitchell gives Journal the title of "Special Advisor on Youth Affairs". This happens to be the same title that Walter F. Starbuck held as part of the Nixon administration in the novel Jailbird by Kurt Vonnegut, and BKV is known to be a fan of Vonnegut's work.
Mitchell detours the second airplane during the Sept 11 attacks, while he was (pathetically) still campaigning on election day. It is instrumental in his unprecedented landslide victory as mayor of NYC. And later, his ascension to Vice President