The final page of issue one, for both the characters and the creators. In character, because it reveals that Mitchell Hundred managed to save one of the World Trade Center towers during 9/11, and for the creators because of the extreme Holy Shit Quotient.
Issue #49: Mitchell Hundred has gone into a Heroic BSOD after finding out his mother has been murdered. But when he is told that people are going crazy in the streets, he immediately snaps out of it, figures out the cause in seconds and coordinates a plan to stop the riots. Then he goes even further:
Nolita: What are you doing? Great Machine: Changing.