These characters cannot be killed by Saint of Killers, but would be incapacitated for quite a while.
- Captain Jack Harkness
- Captain Scarlet and Agent Black
- Marvin The Paranoid Android
- Mr. Immortal
- Vancuria (Nai and Mea)
- The Saint of Killers' successor/alternate universe counterpart/mild-mannered secret identity, however, only chooses not to kill them permanently, for undisclosed reasons.
- Ash Ketchum (and Team Rocket)
- Due to recent events, Team Rocket may have forfeited this primary immunity. They still retain the lesser immunity below, however.
- Starscream (He could technically be killed, but as always his Spark would endure and reincarnate).
- The Spark of Betrayal can, however, be contained by the Loyalty portion of the Elements of Harmony or, by extension, The Armor of the Spring Ogre.
- Suzaku Kururugi
- Deadpool
- Chuck Norris
- Kenny McCormick
- Medaka Kurokami, Misogi Kumagawa, Zenkichi Hitoyoshi, Ajimu Najimi, and Iihiko Shishime
As a side note, the characters in the guess directly above completly immune to The Piemaker's touch, As are these others below.