PlotA graduate student who highly admires Sheldon's work in Physics begins to control his life and his routine, prohibiting him from taking joy in his leisure activities and forcing him to devote all his time to research.
- Abhorrent Admirer: While Ramona Nowitzki isn't what most people would consider ugly, her fanatical obsession in Sheldon's work makes him want to get rid of her.
- Expospeak Gag: Howard tries to use this trope to impress Ramona, but she sees through it:Howard: Howard Wolowitz, department of engineering, co-designer of the International Space Station's liquid waste disposal system.
- Here We Go Again!: Sheldon accepts yet another obsessed female fan of his to deliver food to his place.
- Yoko Oh No: Ramona's efforts to keep Sheldon focused on his research work drives a wedge between him and his friends in partaking in their routine geeky activities such as paintball, comic books, video games and Battlestar Galactica (2003) marathons. The montage in which Ramona keeps Sheldon in line is accompanied by the song "Be my Yoko Ono" by the Barenaked Ladies.