These are what we call the 'YMMV items.' Things that some people find in this work. We call them 'your mileage might vary' because not everyone sees these things in the same way. This starts discussions in the trope lists, a thing we don't want. Please use the discussion page if you'd like to discuss any of these items.
Demonic Spiders: Bandersnatches can quickly pull themselves across the room and have a large attack radius with their long arms. The Hunters also return in the second act of the game, and some are poisonous.
Ensemble Darkhorse: Rodrigo Juan Raval had a small fan following back in the day, much of which was due to his having the best voice actor.
A lot of people believe that Steve is alive. Understandable, considering viruses only live and reproduce in living tissue and the T-Veronica can only be spread by direct injection. Wesker in X did hint at him coming back, too. Considering Capcom's annoying habit of ignoring even peripheral characters who obviously survived, don't count on the issue being revisited any time soon.
Some of these people were convinced that Wesker's lackey in Resident Evil 5 was actually Steve instead of Jill during early trailers when the character is shown over a line spoken by the then unknown Irving, an easy assumption to make since no one knew that Jill had even gone missing. The fact that his voice was strained and coughy didn't hurt either, which would make sense seeing as how he had been transformed into a monster, killed, and then revived only to be put under who knows how many ugly experiments. It made up for his annoying voice in this game. This was, of course, until they noticed that the character wore heels. If he does come back, which he won't, it better damn well be in a game with Claire in it.
For a while in early 2012, some fans thought the mercenary character in Resident Evil 6 was Steve.
Moths take the cake. Poisonous, difficult to avoid and you have to run through their corridor multiple times. They only take a few shots to kill, but good luck hitting one. Any that are killed get replaced as soon as you leave the room. If one lands on you, then you have an egg planted on you which will poision Claire as soon as it hatches. Thankfully Chris doesn't have to deal with them, and there's an infinite-use Blue Herb in the same room to cure the poison (if it wasn't there, most players would likely run out of Blue Herbs very quickly, making it more of an Anti-Frustration Feature than anything).
Nintendo Hard: This is, hands down, the hardest classic-style Resident Evil game, period. You get just enough ammo to get by, but not enough to kill everything in the beginning and the game sends plenty of enemies to soak it all up. One thing that certainly doesn't help is the unusually high number of areas that refill with baddies after you've cleared them out.
It has an interesting difficulty curve overall. An initial blind run by a new player is the hardest that the game will ever get, due to several difficult bosses, a couple of well-hidden weapons, and Claire's limited arsenal. With practice, the player soon discovers that the knife in CV is unusually effective and knows how and when to use certain weapons, which makes the game seem a lot easier. There's actually an astonishing amount of ammo lying around the game compared to the previous installments, but it's expected that you're using most of it up in a blind panic.
That One Boss: What's worse than fighting a Tyrant? Fighting one in the confines of a plane before you have any significantly powerful weaponsPROTIP The least painful way to kill Tyrant is to save all thirty of your explosive crossbow bolts and quickly empty your entire stock into him as soon as the fight begins. Immediately turn and hit the cargo release after that, and Tyrant fall down, go boom.
Nosferatu if you're not good with the Sniper Rifle. If you get the bright idea to bring your big guns with you to cover your ass, then you'll just wind up hosing yourself later as they won't be available for most of Chris's half (since you lose control of Claire immediately after the fight and don't control her again until close to the end of the game), so non-skilled snipers are left with the Morton's Fork of either getting stuck at a brick wall of a boss or crippling themselves for most of the latter half of the game.
Alexia's first form. Good God. While not particularly fast, she has an extremely powerful flame attack that's highly unpredictable and hits at a very long range. Get too close and she uses her One-Hit Kill attack on you regardless of your current health. The fight turns into a Curb-Stomp Battle for you if you bring the Magnum, but most first-time players probably won't have it due to it being Lost Forever if you don't perform a Guide Dang It sequence of actions in Claire's half of the game (and God help you if you took all of Claire's big guns to the Nosferatu fight as mentioned above). Have fun restarting 100 times!