Carl: There's something I need to say, ya know. Ever since my son was...never conceived because I never had consensual sex without money involved, I always sorta looked at you as...well, kind've a thing that I could, ya know, live next to in accordance with state law.
Meatwad: Oh, that's sweet. You're trying to say that you love me!
Carl: Eh eh eh, let's not get ahead of ourselves here - (puts on Super Bowl glove) WHO ARE YOU TAKIN' TO THAT FRIGGIN' SUPERBOWL!
Designated Monkey: Master Shake is both a Designated Monkey and a Karma Houdini. When Shake is actively being a jerk and hurting people, he tends to get away with it. But his biggest Humiliation Congas come from his well-intentioned (for him, anyway) stupidity and/or him being an unrelated victim. The most infamous example being in the episode "Bookie".
This is especially demonstrated in the last season where Shake is largely Out of Focus but will still be brutally hurt before the episode ends.
Sure, Carl's rude, obnoxious, and hygienically-challenged, but the sheer amount of shit his neighbors put him through kinda makes one feel sorry for him.
It's debatable but Frylock could also qualify. Though he's usually portrayed as a decent guy, he can be pretty bitter but considering that he has to put up with everybody else's stupidity all the time (especially Master Shake's), it's not hard to see why.
Mooninites tried to invoke it in "Moonahujana", didn't work on Frylock though.
A forgivable example, but the bees in "Sweet C" are worker bees, and therefore, should've all been female. There go chances of seeing Carl being a Harem Seeker.
Another somewhat forgivable example is the Grand Finale. While good, the only characters to appear are the Aqua Teens, Carl, Carl's friend Dominic, and Meatwad's family. Who else wanted to see characters who were Put on a Bus (such as the Mooninites, the Plutonians, the Cybernetic Ghost, and Dr. Weird) come Back for the Finale? Then again, "Greatest Story" has a lot of those characters (namely, the Mooninites, Plutonians, Markula, Rabbot, Handbanana, Cybernetic Ghost of Christmas Past, Mothmonsterman, Zucotti Manicotti, and Romulux) as Shake's 'acolytes'.
What Do You Mean, It's Not Symbolic?: "The Greatest Story Ever Told" as its name implies is filled with religious parodies. It was released on Adult Swim's website 3 days after the show's supposed cancellation, mirroring the death and resurrection of Jesus.